Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Eric COURCHESNE |
Documents disponibles écrits par cet auteur (11)
Faire une suggestion Affiner la recherche
Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders / Natacha AKSHOOMOFF in Journal of Autism and Developmental Disorders, 37-5 (May 2007)
[article]
Titre : Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Natacha AKSHOOMOFF, Auteur ; Nikdokht FARID, Auteur ; Eric COURCHESNE, Auteur ; Richard HAAS, Auteur Année de publication : 2007 Article en page(s) : p.887-893 Langues : Anglais (eng) Mots-clés : Neurology Seizures EEG Index. décimale : PER Périodiques Résumé : This study examined the nature and frequency of neurological and EEG abnormalities in 60 young children (ages 2–6 years) with pervasive developmental disorders. A number of standard neurological functions could not be adequately assessed due to the young age of the children and/or limited comprehension and cooperation. The most common neurological deficits were hyporeflexia, stereotypies, and hypotonia. EEG abnormalities were identified in 32% of the children while only two children were known to have clinical seizures. The frequency of cases with hypotonia or hyporeflexia was more common than in older children with this diagnosis. Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0216-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140
in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.887-893[article] Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Natacha AKSHOOMOFF, Auteur ; Nikdokht FARID, Auteur ; Eric COURCHESNE, Auteur ; Richard HAAS, Auteur . - 2007 . - p.887-893.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.887-893
Mots-clés : Neurology Seizures EEG Index. décimale : PER Périodiques Résumé : This study examined the nature and frequency of neurological and EEG abnormalities in 60 young children (ages 2–6 years) with pervasive developmental disorders. A number of standard neurological functions could not be adequately assessed due to the young age of the children and/or limited comprehension and cooperation. The most common neurological deficits were hyporeflexia, stereotypies, and hypotonia. EEG abnormalities were identified in 32% of the children while only two children were known to have clinical seizures. The frequency of cases with hypotonia or hyporeflexia was more common than in older children with this diagnosis. Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0216-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD / Teresa H. WEN ; Lauren KUPIS ; Lisa T. EYLER ; Vani TALUJA ; Jaden TROXEL ; Disha GOEL ; Michael V. LOMBARDO ; Karen PIERCE ; Eric COURCHESNE in Molecular Autism, 14 (2023)
[article]
Titre : Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD Type de document : Texte imprimé et/ou numérique Auteurs : Teresa H. WEN, Auteur ; Lauren KUPIS, Auteur ; Lisa T. EYLER, Auteur ; Vani TALUJA, Auteur ; Jaden TROXEL, Auteur ; Disha GOEL, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Social and language abilities are closely intertwined during early typical development. In autism spectrum disorder (ASD), however, deficits in social and language development are early-age core symptoms. We previously reported that superior temporal cortex, a well-established social and language region, shows reduced activation to social affective speech in ASD toddlers; however, the atypical cortical connectivity that accompanies this deviance remains unknown. METHODS: We collected clinical, eye tracking, and resting-state fMRI data from 86 ASD and non-ASD subjects (mean age 2.3?+?0.7 years). Functional connectivity of left and right superior temporal regions with other cortical regions and correlations between this connectivity and each child's social and language abilities were examined. RESULTS: While there was no group difference in functional connectivity, the connectivity between superior temporal cortex and frontal and parietal regions was significantly correlated with language, communication, and social abilities in non-ASD subjects, but these effects were absent in ASD subjects. Instead, ASD subjects, regardless of different social or nonsocial visual preferences, showed atypical correlations between temporal-visual region connectivity and communication ability (r(49)=0.55, p<0.001) and between temporal-precuneus connectivity and expressive language ability (r(49)=0.58, p<0.001). LIMITATIONS: The distinct connectivity-behavior correlation patterns may be related to different developmental stages in ASD and non-ASD subjects. The use of a prior 2-year-old template for spatial normalization may not be optimal for a few subjects beyond this age range. CONCLUSIONS: Superior temporal cortex is known to have reduced activation to social affective speech in ASD at early ages, and here we find in ASD toddlers that it also has atypical connectivity with visual and precuneus cortices that is correlated with communication and language ability, a pattern not seen in non-ASD toddlers. This atypicality may be an early-age signature of ASD that also explains why the disorder has deviant early language and social development. Given that these atypical connectivity patterns are also present in older individuals with ASD, we conclude these atypical connectivity patterns persist across age and may explain why successful interventions targeting language and social skills at all ages in ASD are so difficult to achieve. En ligne : http://dx.doi.org/10.1186/s13229-023-00543-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 11 p.[article] Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD [Texte imprimé et/ou numérique] / Teresa H. WEN, Auteur ; Lauren KUPIS, Auteur ; Lisa T. EYLER, Auteur ; Vani TALUJA, Auteur ; Jaden TROXEL, Auteur ; Disha GOEL, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur . - 11 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 11 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: Social and language abilities are closely intertwined during early typical development. In autism spectrum disorder (ASD), however, deficits in social and language development are early-age core symptoms. We previously reported that superior temporal cortex, a well-established social and language region, shows reduced activation to social affective speech in ASD toddlers; however, the atypical cortical connectivity that accompanies this deviance remains unknown. METHODS: We collected clinical, eye tracking, and resting-state fMRI data from 86 ASD and non-ASD subjects (mean age 2.3?+?0.7 years). Functional connectivity of left and right superior temporal regions with other cortical regions and correlations between this connectivity and each child's social and language abilities were examined. RESULTS: While there was no group difference in functional connectivity, the connectivity between superior temporal cortex and frontal and parietal regions was significantly correlated with language, communication, and social abilities in non-ASD subjects, but these effects were absent in ASD subjects. Instead, ASD subjects, regardless of different social or nonsocial visual preferences, showed atypical correlations between temporal-visual region connectivity and communication ability (r(49)=0.55, p<0.001) and between temporal-precuneus connectivity and expressive language ability (r(49)=0.58, p<0.001). LIMITATIONS: The distinct connectivity-behavior correlation patterns may be related to different developmental stages in ASD and non-ASD subjects. The use of a prior 2-year-old template for spatial normalization may not be optimal for a few subjects beyond this age range. CONCLUSIONS: Superior temporal cortex is known to have reduced activation to social affective speech in ASD at early ages, and here we find in ASD toddlers that it also has atypical connectivity with visual and precuneus cortices that is correlated with communication and language ability, a pattern not seen in non-ASD toddlers. This atypicality may be an early-age signature of ASD that also explains why the disorder has deviant early language and social development. Given that these atypical connectivity patterns are also present in older individuals with ASD, we conclude these atypical connectivity patterns persist across age and may explain why successful interventions targeting language and social skills at all ages in ASD are so difficult to achieve. En ligne : http://dx.doi.org/10.1186/s13229-023-00543-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 L'autisme : un trouble neurodéveloppemental / Eric COURCHESNE in Bulletin Scientifique de l'arapi (Le), 30 (décembre 2012)
[article]
Titre : L'autisme : un trouble neurodéveloppemental Type de document : Texte imprimé et/ou numérique Auteurs : Eric COURCHESNE, Auteur Année de publication : 2012 Article en page(s) : p.74-76 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Bulletin Scientifique de l'arapi (Le) > 30 (décembre 2012) . - p.74-76[article] L'autisme : un trouble neurodéveloppemental [Texte imprimé et/ou numérique] / Eric COURCHESNE, Auteur . - 2012 . - p.74-76.
Langues : Français (fre)
in Bulletin Scientifique de l'arapi (Le) > 30 (décembre 2012) . - p.74-76
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 L'autisme, un trouble progressif et multi-stade du développent foetal / Eric COURCHESNE in Sésame, 214 (Juin 2020)
[article]
Titre : L'autisme, un trouble progressif et multi-stade du développent foetal Type de document : Texte imprimé et/ou numérique Auteurs : Eric COURCHESNE, Auteur Année de publication : 2020 Article en page(s) : p.26 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Sésame > 214 (Juin 2020) . - p.26[article] L'autisme, un trouble progressif et multi-stade du développent foetal [Texte imprimé et/ou numérique] / Eric COURCHESNE, Auteur . - 2020 . - p.26.
Langues : Français (fre)
in Sésame > 214 (Juin 2020) . - p.26
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder / Christie PHAM in Autism, 27-6 (August 2023)
[article]
Titre : Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christie PHAM, Auteur ; Elizabeth C BACON, Auteur ; Andrea GRZYBOWSKI, Auteur ; Cynthia CARTER-BARNES, Auteur ; Steven ARIAS, Auteur ; Ronghui XU, Auteur ; Linda LOPEZ, Auteur ; Eric COURCHESNE, Auteur ; Karen PIERCE, Auteur Article en page(s) : p.1790-1802 Langues : Anglais (eng) Mots-clés : autism spectrum disorders;development;family functioning and support;health services;race and ethnicity Index. décimale : PER Périodiques Résumé : Delays in autism spectrum disorder identification/services could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified later and have reduced engagement in care. It is unclear if disparities exist throughout the screen-evaluate-treat chain, or if early detection programs such as Get SET Early that standardize these steps are effective countermeasures. Pediatricians/primary care providers administered Communication and Symbolic Behavior Scales IT Checklist screens at 12-, 18-, and 24-month well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose pediatricians/primary care providers had concerns, were referred for evaluations. Rates of screening and evaluation engagement within ethnic/racial groups were compared to U.S. Census proportions. Age at screen, evaluation, and treatment and quantity was compared across groups. Regressions examined whether key factors were associated with ethnicity or race. No differences were found for mean age of screen, evaluation, initiation of behavioral therapy, or quantity received between racial and ethnic groups. Historically underrepresented minority children were more likely to fall into the range of concern, referred for evaluations, and have their parents express developmental concerns. Although there remain gaps within the pipeline, implementation of systemized programs can be effective in ensuring equitable access to resources across communities.Lay abstractDelays in autism spectrum disorder identification and access to care could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified at later ages and have reduced engagement in services. It is unclear if disparities exist all along the screen-evaluation-treatment chain, or if early detection programs such as Get SET Early that standardize, these steps are effective at ameliorating disparities. As part of the Get SET Early model, primary care providers administered a parent-report screen at well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose primary care provider had concerns, were referred for an evaluation. Rates of screening and evaluation engagement within ethnic/racial groups were compared to US Census data. Age at screen, evaluation, and treatment engagement and quantity was compared across groups. Statistical models examined whether key factors such as parent concern were associated with ethnicity or race. No differences were found in the mean age at the first screen, evaluation, or initiation or quantity of behavioral therapy between participants. However, children from historically underrepresented minority backgrounds were more likely to fall into the range of concern on the parent-report screen, their parents expressed developmental concerns more often, and pediatricians were more likely to refer for an evaluation than their White/Not Hispanic counterparts. Overall results suggest that models that support transparent tracking of steps in the screen-evaluation-treatment chain and service referral pipelines may be an effective strategy for ensuring equitable access to care for all children. En ligne : http://dx.doi.org/10.1177/13623613221147416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509
in Autism > 27-6 (August 2023) . - p.1790-1802[article] Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder [Texte imprimé et/ou numérique] / Christie PHAM, Auteur ; Elizabeth C BACON, Auteur ; Andrea GRZYBOWSKI, Auteur ; Cynthia CARTER-BARNES, Auteur ; Steven ARIAS, Auteur ; Ronghui XU, Auteur ; Linda LOPEZ, Auteur ; Eric COURCHESNE, Auteur ; Karen PIERCE, Auteur . - p.1790-1802.
Langues : Anglais (eng)
in Autism > 27-6 (August 2023) . - p.1790-1802
Mots-clés : autism spectrum disorders;development;family functioning and support;health services;race and ethnicity Index. décimale : PER Périodiques Résumé : Delays in autism spectrum disorder identification/services could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified later and have reduced engagement in care. It is unclear if disparities exist throughout the screen-evaluate-treat chain, or if early detection programs such as Get SET Early that standardize these steps are effective countermeasures. Pediatricians/primary care providers administered Communication and Symbolic Behavior Scales IT Checklist screens at 12-, 18-, and 24-month well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose pediatricians/primary care providers had concerns, were referred for evaluations. Rates of screening and evaluation engagement within ethnic/racial groups were compared to U.S. Census proportions. Age at screen, evaluation, and treatment and quantity was compared across groups. Regressions examined whether key factors were associated with ethnicity or race. No differences were found for mean age of screen, evaluation, initiation of behavioral therapy, or quantity received between racial and ethnic groups. Historically underrepresented minority children were more likely to fall into the range of concern, referred for evaluations, and have their parents express developmental concerns. Although there remain gaps within the pipeline, implementation of systemized programs can be effective in ensuring equitable access to resources across communities.Lay abstractDelays in autism spectrum disorder identification and access to care could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified at later ages and have reduced engagement in services. It is unclear if disparities exist all along the screen-evaluation-treatment chain, or if early detection programs such as Get SET Early that standardize, these steps are effective at ameliorating disparities. As part of the Get SET Early model, primary care providers administered a parent-report screen at well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose primary care provider had concerns, were referred for an evaluation. Rates of screening and evaluation engagement within ethnic/racial groups were compared to US Census data. Age at screen, evaluation, and treatment engagement and quantity was compared across groups. Statistical models examined whether key factors such as parent concern were associated with ethnicity or race. No differences were found in the mean age at the first screen, evaluation, or initiation or quantity of behavioral therapy between participants. However, children from historically underrepresented minority backgrounds were more likely to fall into the range of concern on the parent-report screen, their parents expressed developmental concerns more often, and pediatricians were more likely to refer for an evaluation than their White/Not Hispanic counterparts. Overall results suggest that models that support transparent tracking of steps in the screen-evaluation-treatment chain and service referral pipelines may be an effective strategy for ensuring equitable access to care for all children. En ligne : http://dx.doi.org/10.1177/13623613221147416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample / Camille W. BRUNE in Autism Research, 1-2 (April 2008)
PermalinkFrom Toddlers to Adults: The Changing Landscape of the Brain in Autism / Eric COURCHESNE
PermalinkIdentifying prognostic markers in autism spectrum disorder using eye tracking / Elizabeth C. BACON in Autism, 24-3 (April 2020)
PermalinkA neurophysiological view of autism / Eric COURCHESNE
PermalinkOffering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)
PermalinkRethinking the idea of late autism spectrum disorder onset / Elizabeth C. BACON in Development and Psychopathology, 30-2 (May 2018)
Permalink