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Auteur Stephen V. FARAONE |
Documents disponibles écrits par cet auteur (22)
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Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD / Henrik UEBEL in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)
[article]
Titre : Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Henrik UEBEL, Auteur ; Aribert ROTHENBERGER, Auteur ; Hanna CHRISTIANSEN, Auteur ; Rafaela MARCO, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Norbert A. BORGER, Auteur ; Alexander HEISE, Auteur ; Ulrike SCHAFER, Auteur ; Robert D. OADES, Auteur ; Louise BUTLER, Auteur ; Aisling MULLIGAN, Auteur ; Wai CHEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Björn ALBRECHT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jaap VAN DER MEERE, Auteur ; Penelope ANDREOU, Auteur Année de publication : 2010 Article en page(s) : p.210-218 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder ADHD endophenotype executive-function reaction-time-variability false-alarms state-regulation incentives Index. décimale : PER Périodiques Résumé : Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be modulated by motivational factors and/or state-regulation processes. The aim of this study was (1) to determine if these executive functions may constitute an endophenotype for ADHD; (2) to investigate for the first time whether known modulators of these executive functions may also be familial; and (3) to explore whether gender has an impact on these measures.
Methods: Two hundred and five children with ADHD combined type, 173 nonaffected biological siblings and 53 controls with no known family history of ADHD were examined using a Go/Nogo task in the framework of a multi-centre study. Performance-measures and modulating effects of event-rate and incentives were examined. Shared familial effects on these measures were assessed, and the influence of gender was tested.
Results: Children with ADHD responded more slowly and variably than nonaffected siblings or controls. Nonaffected siblings showed intermediate scores for reaction-time variability, false alarms and omission errors under fast and slow event-rates. A slower event-rate did not lead to reduced performance specific to ADHD. In the incentive condition, mean reaction-times speeded up and became less variable only in children with ADHD and their nonaffected siblings, while accuracy was improved in all groups. Males responded faster, but also committed more false alarms. There were no interactions of group by gender.
Conclusions: Reaction-time variability and accuracy parameters could be useful neuropsychological endophenotypes for ADHD. Performance-modulating effects of incentives suggested a familially driven motivational dysfunction which may play an important role on etiologic pathways and treatment approaches for ADHD. The effects of gender were independent of familial effects or ADHD-status, which in turn suggests that the proposed endophenotypes are independent of gender.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02139.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.210-218[article] Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD [Texte imprimé et/ou numérique] / Henrik UEBEL, Auteur ; Aribert ROTHENBERGER, Auteur ; Hanna CHRISTIANSEN, Auteur ; Rafaela MARCO, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Norbert A. BORGER, Auteur ; Alexander HEISE, Auteur ; Ulrike SCHAFER, Auteur ; Robert D. OADES, Auteur ; Louise BUTLER, Auteur ; Aisling MULLIGAN, Auteur ; Wai CHEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Björn ALBRECHT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jaap VAN DER MEERE, Auteur ; Penelope ANDREOU, Auteur . - 2010 . - p.210-218.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.210-218
Mots-clés : Attention-deficit-hyperactivity-disorder ADHD endophenotype executive-function reaction-time-variability false-alarms state-regulation incentives Index. décimale : PER Périodiques Résumé : Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be modulated by motivational factors and/or state-regulation processes. The aim of this study was (1) to determine if these executive functions may constitute an endophenotype for ADHD; (2) to investigate for the first time whether known modulators of these executive functions may also be familial; and (3) to explore whether gender has an impact on these measures.
Methods: Two hundred and five children with ADHD combined type, 173 nonaffected biological siblings and 53 controls with no known family history of ADHD were examined using a Go/Nogo task in the framework of a multi-centre study. Performance-measures and modulating effects of event-rate and incentives were examined. Shared familial effects on these measures were assessed, and the influence of gender was tested.
Results: Children with ADHD responded more slowly and variably than nonaffected siblings or controls. Nonaffected siblings showed intermediate scores for reaction-time variability, false alarms and omission errors under fast and slow event-rates. A slower event-rate did not lead to reduced performance specific to ADHD. In the incentive condition, mean reaction-times speeded up and became less variable only in children with ADHD and their nonaffected siblings, while accuracy was improved in all groups. Males responded faster, but also committed more false alarms. There were no interactions of group by gender.
Conclusions: Reaction-time variability and accuracy parameters could be useful neuropsychological endophenotypes for ADHD. Performance-modulating effects of incentives suggested a familially driven motivational dysfunction which may play an important role on etiologic pathways and treatment approaches for ADHD. The effects of gender were independent of familial effects or ADHD-status, which in turn suggests that the proposed endophenotypes are independent of gender.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02139.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)
[article]
Titre : Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden Type de document : Texte imprimé et/ou numérique Auteurs : Qi CHEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Arvid SJÖLANDER, Auteur ; Eva SERLACHIUS, Auteur ; Samuele CORTESE, Auteur ; Stephen V. FARAONE, Auteur ; Catarina ALMQVIST, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.711-718 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder obesity family factors genetics Index. décimale : PER Périodiques Résumé : Background Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. Methods By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973–1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973–2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings. Results Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05–1.24; obesity: OR = 1.42, 95% CI = 1.24–1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04–1.22; obesity: OR = 1.38, 95% CI = 1.21–1.57). The results were similar across sex of the siblings. Conclusions Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308
in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.711-718[article] Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden [Texte imprimé et/ou numérique] / Qi CHEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Arvid SJÖLANDER, Auteur ; Eva SERLACHIUS, Auteur ; Samuele CORTESE, Auteur ; Stephen V. FARAONE, Auteur ; Catarina ALMQVIST, Auteur ; Henrik LARSSON, Auteur . - p.711-718.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.711-718
Mots-clés : Attention-deficit/hyperactivity disorder obesity family factors genetics Index. décimale : PER Périodiques Résumé : Background Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. Methods By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973–1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973–2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings. Results Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05–1.24; obesity: OR = 1.42, 95% CI = 1.24–1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04–1.22; obesity: OR = 1.38, 95% CI = 1.21–1.57). The results were similar across sex of the siblings. Conclusions Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 SLC9A9 Co-expression modules in autism-associated brain regions / Jameson PATAK in Autism Research, 10-3 (March 2017)
[article]
Titre : SLC9A9 Co-expression modules in autism-associated brain regions Type de document : Texte imprimé et/ou numérique Auteurs : Jameson PATAK, Auteur ; Jonathan L. HESS, Auteur ; Yanli ZHANG-JAMES, Auteur ; Stephen J. GLATT, Auteur ; Stephen V. FARAONE, Auteur Article en page(s) : p.414-429 Langues : Anglais (eng) Mots-clés : SLC9A9 weighted gene co-expression network analysis Autism spectrum disorder endosomal pathway transcriptome Index. décimale : PER Périodiques Résumé : SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. It is implicated in neuropsychiatric disorders, including autism spectrum disorders (ASDs). Little research concerning its gene expression patterns and biological pathways has been conducted. We sought to investigate its possible biological roles in autism-associated brain regions throughout development. We conducted a weighted gene co-expression network analysis on RNA-seq data downloaded from Brainspan. We compared prenatal and postnatal gene expression networks for three ASD-associated brain regions known to have high SLC9A9 gene expression. We also performed an ASD-associated single nucleotide polymorphism enrichment analysis and a cell signature enrichment analysis. The modules showed differences in gene constituents (membership), gene number, and connectivity throughout time. SLC9A9 was highly associated with immune system functions, metabolism, apoptosis, endocytosis, and signaling cascades. Gene list comparison with co-immunoprecipitation data was significant for multiple modules. We found a disproportionately high autism risk signal among genes constituting the prenatal hippocampal module. The modules were enriched with astrocyte and oligodendrocyte markers. SLC9A9 is potentially involved in the pathophysiology of ASDs. Our investigation confirmed proposed functions for SLC9A9, such as endocytosis and immune regulation, while also revealing potential roles in mTOR signaling and cell survival.. By providing a concise molecular map and interactions, evidence of cell type and implicated brain regions we hope this will guide future research on SLC9A9. En ligne : http://dx.doi.org/10.1002/aur.1670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Autism Research > 10-3 (March 2017) . - p.414-429[article] SLC9A9 Co-expression modules in autism-associated brain regions [Texte imprimé et/ou numérique] / Jameson PATAK, Auteur ; Jonathan L. HESS, Auteur ; Yanli ZHANG-JAMES, Auteur ; Stephen J. GLATT, Auteur ; Stephen V. FARAONE, Auteur . - p.414-429.
Langues : Anglais (eng)
in Autism Research > 10-3 (March 2017) . - p.414-429
Mots-clés : SLC9A9 weighted gene co-expression network analysis Autism spectrum disorder endosomal pathway transcriptome Index. décimale : PER Périodiques Résumé : SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. It is implicated in neuropsychiatric disorders, including autism spectrum disorders (ASDs). Little research concerning its gene expression patterns and biological pathways has been conducted. We sought to investigate its possible biological roles in autism-associated brain regions throughout development. We conducted a weighted gene co-expression network analysis on RNA-seq data downloaded from Brainspan. We compared prenatal and postnatal gene expression networks for three ASD-associated brain regions known to have high SLC9A9 gene expression. We also performed an ASD-associated single nucleotide polymorphism enrichment analysis and a cell signature enrichment analysis. The modules showed differences in gene constituents (membership), gene number, and connectivity throughout time. SLC9A9 was highly associated with immune system functions, metabolism, apoptosis, endocytosis, and signaling cascades. Gene list comparison with co-immunoprecipitation data was significant for multiple modules. We found a disproportionately high autism risk signal among genes constituting the prenatal hippocampal module. The modules were enriched with astrocyte and oligodendrocyte markers. SLC9A9 is potentially involved in the pathophysiology of ASDs. Our investigation confirmed proposed functions for SLC9A9, such as endocytosis and immune regulation, while also revealing potential roles in mTOR signaling and cell survival.. By providing a concise molecular map and interactions, evidence of cell type and implicated brain regions we hope this will guide future research on SLC9A9. En ligne : http://dx.doi.org/10.1002/aur.1670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction / Marieke E. ALTINK in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)
[article]
Titre : The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction Type de document : Texte imprimé et/ou numérique Auteurs : Marieke E. ALTINK, Auteur ; Joseph A. SERGEANT, Auteur ; Wai CHEN, Auteur ; Keeley-Joanne BROOKES, Auteur ; Richard ANNEY, Auteur ; Ellen A. FLIERS, Auteur ; Dorine I.E. SLAATS–WILLEMSE, Auteur ; Barbara FRANKE, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Margaret J. THOMPSON, Auteur ; Michael GILL, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Aisling MULLIGAN, Auteur Année de publication : 2008 Article en page(s) : p.1053-1060 Langues : Anglais (eng) Mots-clés : Dopamine-receptor-D4-gene attention-deficit-hyperactivity-disorder-(ADHD) maternal-smoking-during-pregnancy gene-by-environment-interaction Index. décimale : PER Périodiques Résumé : Background: The dopamine receptor D4 (DRD4) 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by environment (G×E) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project; and further, to test the hypothesis that the direction of effect of the DRD4 7-repeat allele differs between ADHD affected and unaffected children.
Methods: Linear mixed models were used to assess main and interactive effects of the DRD4 7-repeat allele and smoking during pregnancy in 539 ADHD-affected children and their 407 unaffected siblings, aged 6–17 years.
Results: There was some evidence pointing to differential effects of the DRD4 7-repeat allele on ADHD and oppositional symptoms in the affected (fewer symptoms) and unaffected children (increasing ADHD symptoms of teacher ratings). Affected children were more often exposed to prenatal smoking than unaffected children. There were limited main effects of prenatal smoking on severity of symptoms. Given the number of tests performed, no indication was found for G×E interactions.
Conclusion: Despite the large sample size, no G×E interactions were found. The impact of the DRD4 7-repeat allele might differ, depending on affected status and rater. This finding is discussed in terms of differences in the activity of the dopaminergic system and of different genes involved in rater-specific behaviors.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01998.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1053-1060[article] The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction [Texte imprimé et/ou numérique] / Marieke E. ALTINK, Auteur ; Joseph A. SERGEANT, Auteur ; Wai CHEN, Auteur ; Keeley-Joanne BROOKES, Auteur ; Richard ANNEY, Auteur ; Ellen A. FLIERS, Auteur ; Dorine I.E. SLAATS–WILLEMSE, Auteur ; Barbara FRANKE, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Margaret J. THOMPSON, Auteur ; Michael GILL, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Aisling MULLIGAN, Auteur . - 2008 . - p.1053-1060.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1053-1060
Mots-clés : Dopamine-receptor-D4-gene attention-deficit-hyperactivity-disorder-(ADHD) maternal-smoking-during-pregnancy gene-by-environment-interaction Index. décimale : PER Périodiques Résumé : Background: The dopamine receptor D4 (DRD4) 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by environment (G×E) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project; and further, to test the hypothesis that the direction of effect of the DRD4 7-repeat allele differs between ADHD affected and unaffected children.
Methods: Linear mixed models were used to assess main and interactive effects of the DRD4 7-repeat allele and smoking during pregnancy in 539 ADHD-affected children and their 407 unaffected siblings, aged 6–17 years.
Results: There was some evidence pointing to differential effects of the DRD4 7-repeat allele on ADHD and oppositional symptoms in the affected (fewer symptoms) and unaffected children (increasing ADHD symptoms of teacher ratings). Affected children were more often exposed to prenatal smoking than unaffected children. There were limited main effects of prenatal smoking on severity of symptoms. Given the number of tests performed, no indication was found for G×E interactions.
Conclusion: Despite the large sample size, no G×E interactions were found. The impact of the DRD4 7-repeat allele might differ, depending on affected status and rater. This finding is discussed in terms of differences in the activity of the dopaminergic system and of different genes involved in rater-specific behaviors.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01998.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606 The hierarchical factor model of ADHD: invariant across age and national groupings? / Maggie E. TOPLAK in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)
[article]
Titre : The hierarchical factor model of ADHD: invariant across age and national groupings? Type de document : Texte imprimé et/ou numérique Auteurs : Maggie E. TOPLAK, Auteur ; Geoff B. SORGE, Auteur ; David B. FLORA, Auteur ; Wai CHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Richard P. EBSTEIN, Auteur ; Jacques EISENBERG, Auteur ; Barbara FRANKE, Auteur ; Michael GILL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Herbert ROEYERS, Auteur ; Aribert ROTHENBERGER, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Margaret J. THOMPSON, Auteur ; Rosemary TANNOCK, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur Année de publication : 2012 Article en page(s) : p.292-303 Langues : Anglais (eng) Mots-clés : ADHD hierarchical models bifactor model factorial invariance Index. décimale : PER Périodiques Résumé : Objective: To examine the factor structure of attention-deficit/hyperactivity disorder (ADHD) in a clinical sample of 1,373 children and adolescents with ADHD and their 1,772 unselected siblings recruited from different countries across a large age range. Hierarchical and correlated factor analytic models were compared separately in the ADHD and sibling samples, across three different instruments and across parent and teacher informants. Specific consideration was given to factorial invariance analyses across different ages and different countries in the ADHD sample. Method: A sample of children and adolescents between 5 and 17 years of age with ADHD and their unselected siblings was assessed. Participants were recruited from seven European countries and Israel. ADHD symptom data came from a clinical interview with parents Parental Account of Childhood Symptoms and questionnaires from parents and teachers (Conners Parent and Teacher). Results: A hierarchical general factor model with two specific factors best represented the structure of ADHD in both the ADHD and unselected sibling groups, and across informants and instruments. The model was robust and invariant with regard to age differences in the ADHD sample. The model was not strongly invariant across different national groups in the ADHD sample, likely reflecting severity differences across the different centers and not any substantial difference in the clinical presentation of ADHD. Conclusions: The results replicate previous studies of a model with a unitary ADHD component and separable specific traits of inattention and hyperactivity/impulsivity. The unique contribution of this study was finding support for this model across a large developmental and multinational/multicultural sample and its invariance across ages. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02500.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.292-303[article] The hierarchical factor model of ADHD: invariant across age and national groupings? [Texte imprimé et/ou numérique] / Maggie E. TOPLAK, Auteur ; Geoff B. SORGE, Auteur ; David B. FLORA, Auteur ; Wai CHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Richard P. EBSTEIN, Auteur ; Jacques EISENBERG, Auteur ; Barbara FRANKE, Auteur ; Michael GILL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Herbert ROEYERS, Auteur ; Aribert ROTHENBERGER, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Margaret J. THOMPSON, Auteur ; Rosemary TANNOCK, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur . - 2012 . - p.292-303.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.292-303
Mots-clés : ADHD hierarchical models bifactor model factorial invariance Index. décimale : PER Périodiques Résumé : Objective: To examine the factor structure of attention-deficit/hyperactivity disorder (ADHD) in a clinical sample of 1,373 children and adolescents with ADHD and their 1,772 unselected siblings recruited from different countries across a large age range. Hierarchical and correlated factor analytic models were compared separately in the ADHD and sibling samples, across three different instruments and across parent and teacher informants. Specific consideration was given to factorial invariance analyses across different ages and different countries in the ADHD sample. Method: A sample of children and adolescents between 5 and 17 years of age with ADHD and their unselected siblings was assessed. Participants were recruited from seven European countries and Israel. ADHD symptom data came from a clinical interview with parents Parental Account of Childhood Symptoms and questionnaires from parents and teachers (Conners Parent and Teacher). Results: A hierarchical general factor model with two specific factors best represented the structure of ADHD in both the ADHD and unselected sibling groups, and across informants and instruments. The model was robust and invariant with regard to age differences in the ADHD sample. The model was not strongly invariant across different national groups in the ADHD sample, likely reflecting severity differences across the different centers and not any substantial difference in the clinical presentation of ADHD. Conclusions: The results replicate previous studies of a model with a unitary ADHD component and separable specific traits of inattention and hyperactivity/impulsivity. The unique contribution of this study was finding support for this model across a large developmental and multinational/multicultural sample and its invariance across ages. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02500.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: A longitudinal study / Michael C. MONUTEAUX in Journal of Child Psychology and Psychiatry, 51-3 (March 2010)
PermalinkThe serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder / Dennis VAN DER MEER in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
PermalinkWhite matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)
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