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Auteur Eleonora NAPOLI |
Documents disponibles écrits par cet auteur (2)
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Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism / Eleonora NAPOLI in Molecular Autism, (January 2013)
[article]
Titre : Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism Type de document : Texte imprimé et/ou numérique Auteurs : Eleonora NAPOLI, Auteur ; Sarah WONG, Auteur ; Cecilia GIULIVI, Auteur Année de publication : 2013 Article en page(s) : 8 p. Mots-clés : Autism Mitochondria Mitochondrial DNA Oxidative damage Bioenergetics Index. décimale : PER Périodiques Résumé : BACKGROUND:The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of oxidative stress have been found in tissues from children with autism spectrum disorders, evidence for damage to mtDNA is lacking.FINDINGS:mtDNA deletions were evaluated in peripheral blood monocytic cells (PBMC) isolated from 2-5 year old children with full autism (AU; n = 67), and typically developing children (TD; n = 46) and their parents enrolled in the CHildhood Autism Risk from Genes and Environment study (CHARGE) at University of California Davis. Sequence variants were evaluated in mtDNA segments from AU and TD children (n = 10; each) and their mothers representing 31.2% coverage of the entire human mitochondrial genome. Increased mtDNA damage in AU children was evidenced by (i) higher frequency of mtDNA deletions (2-fold), (ii) higher number of GC-AT transitions (2.4-fold), being GC preferred sites for oxidative damage, and (iii) higher frequency of G,C,T-A transitions (1.6-fold) suggesting a higher incidence of polymerase gamma incorporating mainly A at bypassed apurinic/apyrimidinic sites, probably originated from oxidative stress. The last two outcomes were identical to their mothers suggesting the inheritance of a template consistent with increased oxidative damage, whereas the frequency of mtDNA deletions in AU children was similar to that of their fathers.CONCLUSIONS:These results suggest that a combination of genetic and epigenetic factors, taking place during perinatal periods, results in a mtDNA template in children with autism similar to that expected for older individuals. En ligne : http://dx.doi.org/10.1186/2040-2392-4-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (January 2013) . - 8 p.[article] Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism [Texte imprimé et/ou numérique] / Eleonora NAPOLI, Auteur ; Sarah WONG, Auteur ; Cecilia GIULIVI, Auteur . - 2013 . - 8 p.
in Molecular Autism > (January 2013) . - 8 p.
Mots-clés : Autism Mitochondria Mitochondrial DNA Oxidative damage Bioenergetics Index. décimale : PER Périodiques Résumé : BACKGROUND:The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of oxidative stress have been found in tissues from children with autism spectrum disorders, evidence for damage to mtDNA is lacking.FINDINGS:mtDNA deletions were evaluated in peripheral blood monocytic cells (PBMC) isolated from 2-5 year old children with full autism (AU; n = 67), and typically developing children (TD; n = 46) and their parents enrolled in the CHildhood Autism Risk from Genes and Environment study (CHARGE) at University of California Davis. Sequence variants were evaluated in mtDNA segments from AU and TD children (n = 10; each) and their mothers representing 31.2% coverage of the entire human mitochondrial genome. Increased mtDNA damage in AU children was evidenced by (i) higher frequency of mtDNA deletions (2-fold), (ii) higher number of GC-AT transitions (2.4-fold), being GC preferred sites for oxidative damage, and (iii) higher frequency of G,C,T-A transitions (1.6-fold) suggesting a higher incidence of polymerase gamma incorporating mainly A at bypassed apurinic/apyrimidinic sites, probably originated from oxidative stress. The last two outcomes were identical to their mothers suggesting the inheritance of a template consistent with increased oxidative damage, whereas the frequency of mtDNA deletions in AU children was similar to that of their fathers.CONCLUSIONS:These results suggest that a combination of genetic and epigenetic factors, taking place during perinatal periods, results in a mtDNA template in children with autism similar to that expected for older individuals. En ligne : http://dx.doi.org/10.1186/2040-2392-4-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Executive Functions and Symptom Severity in an Italian Sample of Intellectually Able Preschoolers with Autism Spectrum Disorder / Giovanni VALERI in Journal of Autism and Developmental Disorders, 50-9 (September 2020)
[article]
Titre : Executive Functions and Symptom Severity in an Italian Sample of Intellectually Able Preschoolers with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Giovanni VALERI, Auteur ; Laura CASULA, Auteur ; Eleonora NAPOLI, Auteur ; Paolo STIEVANO, Auteur ; Barbara TRIMARCO, Auteur ; Stefano VICARI, Auteur ; Teresa Gloria SCALISI, Auteur Article en page(s) : p.3207-3215 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Executive functions Inhibition Preschoolers Shifting Working memory Index. décimale : PER Périodiques Résumé : A novel battery (BAFE; Valeri et al. 2015) was used in order to assess three executive function (EF) abilities (working memory, inhibition and shifting) in a sample of 27 intellectually able preschoolers with autism spectrum disorder (ASD) compared with 27 typically developing children matched on age and nonverbal IQ. Differences in EF skills were analyzed in participants with distinct ASD symptom severity. Children with ASD performed worse than typical controls on both set-shifting and inhibition, but not on visuo-spatial working memory. Additionally, children with more severe ASD symptoms showed a worse performance on inhibition than children with milder symptoms. These results confirm the presence of EF deficits and highlight a link between ASD symptoms and EF impairments in preschool age. En ligne : http://dx.doi.org/10.1007/s10803-019-04102-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3207-3215[article] Executive Functions and Symptom Severity in an Italian Sample of Intellectually Able Preschoolers with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Giovanni VALERI, Auteur ; Laura CASULA, Auteur ; Eleonora NAPOLI, Auteur ; Paolo STIEVANO, Auteur ; Barbara TRIMARCO, Auteur ; Stefano VICARI, Auteur ; Teresa Gloria SCALISI, Auteur . - p.3207-3215.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3207-3215
Mots-clés : Autism spectrum disorder Executive functions Inhibition Preschoolers Shifting Working memory Index. décimale : PER Périodiques Résumé : A novel battery (BAFE; Valeri et al. 2015) was used in order to assess three executive function (EF) abilities (working memory, inhibition and shifting) in a sample of 27 intellectually able preschoolers with autism spectrum disorder (ASD) compared with 27 typically developing children matched on age and nonverbal IQ. Differences in EF skills were analyzed in participants with distinct ASD symptom severity. Children with ASD performed worse than typical controls on both set-shifting and inhibition, but not on visuo-spatial working memory. Additionally, children with more severe ASD symptoms showed a worse performance on inhibition than children with milder symptoms. These results confirm the presence of EF deficits and highlight a link between ASD symptoms and EF impairments in preschool age. En ligne : http://dx.doi.org/10.1007/s10803-019-04102-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430