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Détail de l'auteur
Auteur Steve C.R. WILLIAMS |
Documents disponibles écrits par cet auteur (2)
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Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot / Mitul A. MEHTA in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)
[article]
Titre : Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot Type de document : Texte imprimé et/ou numérique Auteurs : Mitul A. MEHTA, Auteur ; Michael RUTTER, Auteur ; Emma COLVERT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Steve C.R. WILLIAMS, Auteur ; Nicole I. GOLEMBO, Auteur ; Chiara NOSARTI, Auteur ; Ashley MOTA, Auteur Année de publication : 2009 Article en page(s) : p.943-951 Langues : Anglais (eng) Mots-clés : Corpus-callosum hippocampus amygdala deprivation neurodevelopment institution-rearing adolescence brain-imaging brain-development Index. décimale : PER Périodiques Résumé : The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross-sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain structure. We used magnetic resonance imaging (MRI) to measure the sizes of three key brain regions hypothesized to be sensitive to early adverse experiences. Our sample was a group of adoptee adolescents (N = 14) who had experienced severe early institutional deprivation in Romania and a group of non-institutionalised controls (N = 11). The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non-deprived, non-adopted UK controls. After correcting for difference in brain volume, the institutionalised group had greater amygdala volumes, especially on the right, but no differences were observed in hippocampal volume or corpus callosum mid-sagittal area. The left amygdala volume was also related to the time spent in institutions, with those experiencing longer periods of deprivation having a smaller left amygdala volume. These pilot findings highlight the need for future studies to confirm the sensitivity of the amygdala to early deprivation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02084.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.943-951[article] Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot [Texte imprimé et/ou numérique] / Mitul A. MEHTA, Auteur ; Michael RUTTER, Auteur ; Emma COLVERT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Steve C.R. WILLIAMS, Auteur ; Nicole I. GOLEMBO, Auteur ; Chiara NOSARTI, Auteur ; Ashley MOTA, Auteur . - 2009 . - p.943-951.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.943-951
Mots-clés : Corpus-callosum hippocampus amygdala deprivation neurodevelopment institution-rearing adolescence brain-imaging brain-development Index. décimale : PER Périodiques Résumé : The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross-sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain structure. We used magnetic resonance imaging (MRI) to measure the sizes of three key brain regions hypothesized to be sensitive to early adverse experiences. Our sample was a group of adoptee adolescents (N = 14) who had experienced severe early institutional deprivation in Romania and a group of non-institutionalised controls (N = 11). The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non-deprived, non-adopted UK controls. After correcting for difference in brain volume, the institutionalised group had greater amygdala volumes, especially on the right, but no differences were observed in hippocampal volume or corpus callosum mid-sagittal area. The left amygdala volume was also related to the time spent in institutions, with those experiencing longer periods of deprivation having a smaller left amygdala volume. These pilot findings highlight the need for future studies to confirm the sensitivity of the amygdala to early deprivation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02084.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787 The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study / John D. HERRINGTON in Research in Autism Spectrum Disorders, 1-1 (January/March 2007)
[article]
Titre : The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : John D. HERRINGTON, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Krishna D. SINGH, Auteur ; Edward T. BULLMORE, Auteur ; Michael BRAMMER, Auteur ; Steve C.R. WILLIAMS, Auteur Année de publication : 2007 Article en page(s) : p.14-27 Langues : Anglais (eng) Mots-clés : Asperger-Syndrome Autism fMRI Motion-perception MT+/V5 Temporal-lobe Index. décimale : PER Périodiques Résumé : Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146
in Research in Autism Spectrum Disorders > 1-1 (January/March 2007) . - p.14-27[article] The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study [Texte imprimé et/ou numérique] / John D. HERRINGTON, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Krishna D. SINGH, Auteur ; Edward T. BULLMORE, Auteur ; Michael BRAMMER, Auteur ; Steve C.R. WILLIAMS, Auteur . - 2007 . - p.14-27.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 1-1 (January/March 2007) . - p.14-27
Mots-clés : Asperger-Syndrome Autism fMRI Motion-perception MT+/V5 Temporal-lobe Index. décimale : PER Périodiques Résumé : Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146