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Auteur M. ELSABBAGH |
Documents disponibles écrits par cet auteur (14)



Association between spectral electroencephalography power and autism risk and diagnosis in early development / S. HUBERTY in Autism Research, 14-7 (July 2021)
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[article]
Titre : Association between spectral electroencephalography power and autism risk and diagnosis in early development Type de document : Texte imprimé et/ou numérique Auteurs : S. HUBERTY, Auteur ; Virginia CARTER LENO, Auteur ; S. J. R. VAN NOORDT, Auteur ; Rachael BEDFORD, Auteur ; A. PICKLES, Auteur ; James A. DESJARDINS, Auteur ; S. J. WEBB, Auteur ; M. ELSABBAGH, Auteur Article en page(s) : p.1390-1403 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Brain Child, Preschool Electroencephalography Humans Infant Siblings Eeg autism spectrum disorders infants siblings Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has its origins in the atypical development of brain networks. Infants who are at high familial risk for, and later diagnosed with ASD, show atypical activity in multiple electroencephalography (EEG) oscillatory measures. However, infant-sibling studies are often constrained by small sample sizes. We used the International Infant EEG Data Integration Platform, a multi-site dataset with 432 participants, including 222 at high-risk for ASD, from whom repeated measurements of EEG were collected between the ages of 3-36?months. We applied a latent growth curve model to test whether familial risk status predicts developmental trajectories of spectral power across the first 3?years of life, and whether these trajectories predict ASD outcome. Change in spectral EEG power in all frequency bands occurred during the first 3?years of life. Familial risk, but not a later diagnosis of ASD, was associated with reduced power at 3?months, and a steeper developmental change between 3 and 36?months in nearly all absolute power bands. ASD outcome was not associated with absolute power intercept or slope. No associations were found between risk or outcome and relative power. This study applied an analytic approach not used in previous prospective biomarker studies of ASD, which was modeled to reflect the temporal relationship between genetic susceptibility, brain development, and ASD diagnosis. Trajectories of spectral power appear to be predicted by familial risk; however, spectral power does not predict diagnostic outcome above and beyond familial risk status. Discrepancies between current results and previous studies are discussed. LAY SUMMARY: Infants with an older sibling who is diagnosed with ASD are at increased risk of developing ASD themselves. This article tested whether EEG spectral power in the first year of life can predict whether these infants did or did not develop ASD. En ligne : http://dx.doi.org/10.1002/aur.2518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-7 (July 2021) . - p.1390-1403[article] Association between spectral electroencephalography power and autism risk and diagnosis in early development [Texte imprimé et/ou numérique] / S. HUBERTY, Auteur ; Virginia CARTER LENO, Auteur ; S. J. R. VAN NOORDT, Auteur ; Rachael BEDFORD, Auteur ; A. PICKLES, Auteur ; James A. DESJARDINS, Auteur ; S. J. WEBB, Auteur ; M. ELSABBAGH, Auteur . - p.1390-1403.
Langues : Anglais (eng)
in Autism Research > 14-7 (July 2021) . - p.1390-1403
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Brain Child, Preschool Electroencephalography Humans Infant Siblings Eeg autism spectrum disorders infants siblings Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has its origins in the atypical development of brain networks. Infants who are at high familial risk for, and later diagnosed with ASD, show atypical activity in multiple electroencephalography (EEG) oscillatory measures. However, infant-sibling studies are often constrained by small sample sizes. We used the International Infant EEG Data Integration Platform, a multi-site dataset with 432 participants, including 222 at high-risk for ASD, from whom repeated measurements of EEG were collected between the ages of 3-36?months. We applied a latent growth curve model to test whether familial risk status predicts developmental trajectories of spectral power across the first 3?years of life, and whether these trajectories predict ASD outcome. Change in spectral EEG power in all frequency bands occurred during the first 3?years of life. Familial risk, but not a later diagnosis of ASD, was associated with reduced power at 3?months, and a steeper developmental change between 3 and 36?months in nearly all absolute power bands. ASD outcome was not associated with absolute power intercept or slope. No associations were found between risk or outcome and relative power. This study applied an analytic approach not used in previous prospective biomarker studies of ASD, which was modeled to reflect the temporal relationship between genetic susceptibility, brain development, and ASD diagnosis. Trajectories of spectral power appear to be predicted by familial risk; however, spectral power does not predict diagnostic outcome above and beyond familial risk status. Discrepancies between current results and previous studies are discussed. LAY SUMMARY: Infants with an older sibling who is diagnosed with ASD are at increased risk of developing ASD themselves. This article tested whether EEG spectral power in the first year of life can predict whether these infants did or did not develop ASD. En ligne : http://dx.doi.org/10.1002/aur.2518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Assuming ability of youth with autism: Synthesis of methods capturing the first-person perspectives of children and youth with disabilities / R. TESFAYE in Autism, 23-8 (November 2019)
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Titre : Assuming ability of youth with autism: Synthesis of methods capturing the first-person perspectives of children and youth with disabilities Type de document : Texte imprimé et/ou numérique Auteurs : R. TESFAYE, Auteur ; V. COURCHESNE, Auteur ; A. YUSUF, Auteur ; T. SAVION-LEMIEUX, Auteur ; I. SINGH, Auteur ; K. SHIKAKO-THOMAS, Auteur ; P. MIRENDA, Auteur ; C. WADDELL, Auteur ; I. M. SMITH, Auteur ; David B NICHOLAS, Auteur ; P. SZATMARI, Auteur ; Teresa BENNETT, Auteur ; E. DUKU, Auteur ; S. GEORGIADES, Auteur ; Connor M. KERNS, Auteur ; T. VAILLANCOURT, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur Article en page(s) : p.1882-1896 Langues : Anglais (eng) Mots-clés : Autism disabilities first-person perspective inclusion lived experience participatory research Index. décimale : PER Périodiques Résumé : Most research regarding youth with autism spectrum disorder has not focused on their first-person perspectives providing limited insight into methodologies best suited to eliciting their voices. We conducted a synthesis of methods previously used to obtain the first-person perspectives of youth with various disabilities, which may be applicable to youth with autism spectrum disorder. Two-hundred and eighty-four articles met the inclusion criteria of our scoping review. We identified six distinct primary methods (questionnaires, interviews, group discussion, narratives, diaries, and art) expressed through four communication output modalities (language, sign language and gestures, writing, and images). A group of parents who have children with autism spectrum disorder were then presented with a synthesis of results. This parent consultation was used to build on approaches identified in the literature. Parents identified barriers that may be encountered during participant engagement and provided insights on how best to conduct first-person research with youth with autism spectrum disorder. Based on our findings, we present a novel methodological framework to capture the perspectives of youth with various communication and cognitive abilities, while highlighting family, youth, and expert contributions. En ligne : http://dx.doi.org/10.1177/1362361319831487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407
in Autism > 23-8 (November 2019) . - p.1882-1896[article] Assuming ability of youth with autism: Synthesis of methods capturing the first-person perspectives of children and youth with disabilities [Texte imprimé et/ou numérique] / R. TESFAYE, Auteur ; V. COURCHESNE, Auteur ; A. YUSUF, Auteur ; T. SAVION-LEMIEUX, Auteur ; I. SINGH, Auteur ; K. SHIKAKO-THOMAS, Auteur ; P. MIRENDA, Auteur ; C. WADDELL, Auteur ; I. M. SMITH, Auteur ; David B NICHOLAS, Auteur ; P. SZATMARI, Auteur ; Teresa BENNETT, Auteur ; E. DUKU, Auteur ; S. GEORGIADES, Auteur ; Connor M. KERNS, Auteur ; T. VAILLANCOURT, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur . - p.1882-1896.
Langues : Anglais (eng)
in Autism > 23-8 (November 2019) . - p.1882-1896
Mots-clés : Autism disabilities first-person perspective inclusion lived experience participatory research Index. décimale : PER Périodiques Résumé : Most research regarding youth with autism spectrum disorder has not focused on their first-person perspectives providing limited insight into methodologies best suited to eliciting their voices. We conducted a synthesis of methods previously used to obtain the first-person perspectives of youth with various disabilities, which may be applicable to youth with autism spectrum disorder. Two-hundred and eighty-four articles met the inclusion criteria of our scoping review. We identified six distinct primary methods (questionnaires, interviews, group discussion, narratives, diaries, and art) expressed through four communication output modalities (language, sign language and gestures, writing, and images). A group of parents who have children with autism spectrum disorder were then presented with a synthesis of results. This parent consultation was used to build on approaches identified in the literature. Parents identified barriers that may be encountered during participant engagement and provided insights on how best to conduct first-person research with youth with autism spectrum disorder. Based on our findings, we present a novel methodological framework to capture the perspectives of youth with various communication and cognitive abilities, while highlighting family, youth, and expert contributions. En ligne : http://dx.doi.org/10.1177/1362361319831487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time / K. T. COST in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
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Titre : "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time Type de document : Texte imprimé et/ou numérique Auteurs : K. T. COST, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; P. MIRENDA, Auteur ; E. DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; Connor M. KERNS, Auteur ; Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; S. GEORGIADES, Auteur ; C. WADDELL, Auteur ; M. ELSABBAGH, Auteur ; T. VAILLANCOURT, Auteur Article en page(s) : p.4560-4574 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Checklist Child Child, Preschool Humans Parents Autism spectrum disorder Character traits Children Positive psychology Strengths Index. décimale : PER Périodiques Résumé : This study examined parental perceptions of the character traits of children with autism from early childhood to age 11. Parents (n?=?153) provided descriptions of the "best things" about their children on the Child Behavior Checklist (CBCL) at ages 3-4, 7-8, and 10-11 years. Descriptions were coded using the framework of the Values in Action Classification of Strengths, with additional traits added as needed. Parent-endorsed traits included love, kindness, happiness, and humor in children across all ages and traits such as perseverance as children entered school. Higher CBCL scores were associated with a lower likelihood of endorsement for Humanity traits. Results are congruent with a contemporary neurodiversity perspective that emphasizes strengths and resilience. En ligne : http://dx.doi.org/10.1007/s10803-021-04890-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4560-4574[article] "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time [Texte imprimé et/ou numérique] / K. T. COST, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; P. MIRENDA, Auteur ; E. DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; Connor M. KERNS, Auteur ; Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; S. GEORGIADES, Auteur ; C. WADDELL, Auteur ; M. ELSABBAGH, Auteur ; T. VAILLANCOURT, Auteur . - p.4560-4574.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4560-4574
Mots-clés : Autism Spectrum Disorder Autistic Disorder Checklist Child Child, Preschool Humans Parents Autism spectrum disorder Character traits Children Positive psychology Strengths Index. décimale : PER Périodiques Résumé : This study examined parental perceptions of the character traits of children with autism from early childhood to age 11. Parents (n?=?153) provided descriptions of the "best things" about their children on the Child Behavior Checklist (CBCL) at ages 3-4, 7-8, and 10-11 years. Descriptions were coded using the framework of the Values in Action Classification of Strengths, with additional traits added as needed. Parent-endorsed traits included love, kindness, happiness, and humor in children across all ages and traits such as perseverance as children entered school. Higher CBCL scores were associated with a lower likelihood of endorsement for Humanity traits. Results are congruent with a contemporary neurodiversity perspective that emphasizes strengths and resilience. En ligne : http://dx.doi.org/10.1007/s10803-021-04890-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Correction to: "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time / K. T. COST in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
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Titre : Correction to: "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time Type de document : Texte imprimé et/ou numérique Auteurs : K. T. COST, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; P. MIRENDA, Auteur ; E. DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; Connor M. KERNS, Auteur ; Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; S. GEORGIADES, Auteur ; C. WADDELL, Auteur ; M. ELSABBAGH, Auteur ; T. VAILLANCOURT, Auteur Article en page(s) : p.4575-4576 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05144-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4575-4576[article] Correction to: "Best Things": Parents Describe Their Children with Autism Spectrum Disorder Over Time [Texte imprimé et/ou numérique] / K. T. COST, Auteur ; A. ZAIDMAN-ZAIT, Auteur ; P. MIRENDA, Auteur ; E. DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur ; W. J. UNGAR, Auteur ; Connor M. KERNS, Auteur ; Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; S. GEORGIADES, Auteur ; C. WADDELL, Auteur ; M. ELSABBAGH, Auteur ; T. VAILLANCOURT, Auteur . - p.4575-4576.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4575-4576
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05144-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 EEG hyper-connectivity in high-risk infants is associated with later autism / Elena V. OREKHOVA in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)
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Titre : EEG hyper-connectivity in high-risk infants is associated with later autism Type de document : Texte imprimé et/ou numérique Auteurs : Elena V. OREKHOVA, Auteur ; M. ELSABBAGH, Auteur ; E. J. JONES, Auteur ; G. DAWSON, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur Article en page(s) : p.40 Langues : Anglais (eng) Mots-clés : Alpha Autism spectrum disorders Connectivity Eeg Infants Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: It has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis. METHODS: In the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD. RESULTS: As a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power. CONCLUSIONS: The results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype. En ligne : http://dx.doi.org/10.1186/1866-1955-6-40 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.40[article] EEG hyper-connectivity in high-risk infants is associated with later autism [Texte imprimé et/ou numérique] / Elena V. OREKHOVA, Auteur ; M. ELSABBAGH, Auteur ; E. J. JONES, Auteur ; G. DAWSON, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur . - p.40.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.40
Mots-clés : Alpha Autism spectrum disorders Connectivity Eeg Infants Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: It has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis. METHODS: In the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD. RESULTS: As a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power. CONCLUSIONS: The results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype. En ligne : http://dx.doi.org/10.1186/1866-1955-6-40 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 Ethical dimensions of translational developmental neuroscience research in autism / A. MANZINI in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)
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PermalinkExamining Trajectories of Daily Living Skills over the Preschool Years for Children with Autism Spectrum Disorder / B. DI REZZE in Journal of Autism and Developmental Disorders, 49-11 (November 2019)
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PermalinkGender Differences in Pragmatic Communication in School-Aged Children with Autism Spectrum Disorder (ASD) / O. CONLON in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
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PermalinkLanguage Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles / Teresa BENNETT in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
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PermalinkNeurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood / Rachael BEDFORD in Molecular Autism, 8 (2017)
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PermalinkNon-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised / V. COURCHESNE in Molecular Autism, 12 (2021)
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PermalinkPsychometric Properties of the Spence Children's Anxiety Scale: Parent Report in Children with Autism Spectrum Disorder / K. JITLINA in Journal of Autism and Developmental Disorders, 47-12 (December 2017)
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PermalinkThe subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study / M. ELSABBAGH ; A. PICKLES ; R. BEDFORD in Molecular Autism, 14 (2023)
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PermalinkTrajectories of Symptom Severity in Children with Autism: Variability and Turning Points through the Transition to School / S. GEORGIADES in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
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