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Auteur Alexandra P. KEY |
Documents disponibles écrits par cet auteur (5)
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Audition-specific temporal processing deficits associated with language function in children with autism spectrum disorder / Jennifer H. FOSS-FEIG in Autism Research, 10-11 (November 2017)
[article]
Titre : Audition-specific temporal processing deficits associated with language function in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. FOSS-FEIG, Auteur ; Kimberly B. SCHAUDER, Auteur ; Alexandra P. KEY, Auteur ; Mark T. WALLACE, Auteur ; Wendy L. STONE, Auteur Article en page(s) : p.1845-1856 Langues : Anglais (eng) Mots-clés : ASD audition vision temporal processing language low level perception Index. décimale : PER Périodiques Résumé : Sensory processing alterations are highly prevalent in autism spectrum disorder (ASD). Neurobiologically-based theories of ASD propose that abnormalities in the processing of temporal aspects of sensory input could underlie core symptoms of ASD. For example, rapid auditory temporal processing is critical for speech perception, and language difficulties are central to the social communication deficits defining the disorder. This study assessed visual and auditory temporal processing abilities and tested their relation to core ASD symptoms. 53 children (26 ASD, 27 TD) completed visual and auditory psychophysical gap detection tasks to measure gap detection thresholds (i.e., the minimum interval between sequential stimuli needed for individuals to perceive an interruption between the stimuli) in each domain. Children were also administered standardized language assessments such that the relation between individual differences in auditory gap detection thresholds and degree of language and communication difficulties among children with ASD could be assessed. Children with ASD had substantially higher auditory gap detection thresholds compared to children with TD, and auditory gap detection thresholds were correlated significantly with several measures of language processing in this population. No group differences were observed in the visual temporal processing. Results indicate a domain-specific impairment in rapid auditory temporal processing in ASD that is associated with greater difficulties in language processing. Findings provide qualified support for temporal processing theories of ASD and highlight the need for future research testing the nature, extent, and universality of auditory temporal processing deficits in this population. Autism Res 2017, 10: 1845–1856. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Sensory symptoms are common in ASD. Temporal processing alterations are often implicated, but understudied. The ability to process rapid sensory information, particularly auditory input, is critical for language functioning. This study tested auditory and visual temporal processing in ASD and controls. Findings suggest that rapid auditory (but not visual) processing is impaired in ASD and related to language functioning. These results could provide mechanistic clues to understanding core symptoms and lead to novel intervention targets. En ligne : http://dx.doi.org/10.1002/aur.1820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1845-1856[article] Audition-specific temporal processing deficits associated with language function in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Jennifer H. FOSS-FEIG, Auteur ; Kimberly B. SCHAUDER, Auteur ; Alexandra P. KEY, Auteur ; Mark T. WALLACE, Auteur ; Wendy L. STONE, Auteur . - p.1845-1856.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1845-1856
Mots-clés : ASD audition vision temporal processing language low level perception Index. décimale : PER Périodiques Résumé : Sensory processing alterations are highly prevalent in autism spectrum disorder (ASD). Neurobiologically-based theories of ASD propose that abnormalities in the processing of temporal aspects of sensory input could underlie core symptoms of ASD. For example, rapid auditory temporal processing is critical for speech perception, and language difficulties are central to the social communication deficits defining the disorder. This study assessed visual and auditory temporal processing abilities and tested their relation to core ASD symptoms. 53 children (26 ASD, 27 TD) completed visual and auditory psychophysical gap detection tasks to measure gap detection thresholds (i.e., the minimum interval between sequential stimuli needed for individuals to perceive an interruption between the stimuli) in each domain. Children were also administered standardized language assessments such that the relation between individual differences in auditory gap detection thresholds and degree of language and communication difficulties among children with ASD could be assessed. Children with ASD had substantially higher auditory gap detection thresholds compared to children with TD, and auditory gap detection thresholds were correlated significantly with several measures of language processing in this population. No group differences were observed in the visual temporal processing. Results indicate a domain-specific impairment in rapid auditory temporal processing in ASD that is associated with greater difficulties in language processing. Findings provide qualified support for temporal processing theories of ASD and highlight the need for future research testing the nature, extent, and universality of auditory temporal processing deficits in this population. Autism Res 2017, 10: 1845–1856. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Sensory symptoms are common in ASD. Temporal processing alterations are often implicated, but understudied. The ability to process rapid sensory information, particularly auditory input, is critical for language functioning. This study tested auditory and visual temporal processing in ASD and controls. Findings suggest that rapid auditory (but not visual) processing is impaired in ASD and related to language functioning. These results could provide mechanistic clues to understanding core symptoms and lead to novel intervention targets. En ligne : http://dx.doi.org/10.1002/aur.1820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Erratum to: Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study / Alexandra P. KEY in Journal of Autism and Developmental Disorders, 45-12 (December 2015)
[article]
Titre : Erratum to: Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra P. KEY, Auteur ; Lisa V. IBANEZ, Auteur ; Heather A. HENDERSON, Auteur ; Zachary WARREN, Auteur ; Daniel S. MESSINGER, Auteur ; Wendy L. STONE, Auteur Article en page(s) : p.4063-4063 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Few behavioral indices of risk for autism spectrum disorders (ASD) are present before 12 months, and potential biomarkers remain largely unexamined. This prospective study of infant siblings of children with ASD (n = 16) and low-risk comparison infants (n = 15) examined group differences in event-related potentials (ERPs) indexing processing of facial positive affect (N290/P400, Nc) at 9 months and their relation to joint attention at 15 months. Group differences were most pronounced for subtle facial expressions, in that the low-risk group exhibited relatively longer processing (P400 latency) and greater attention resource allocation (Nc amplitude). Exploratory analyses found associations between ERP responses and later joint attention, suggesting that attention to positive affect cues may support the development of other social competencies. En ligne : http://dx.doi.org/10.1007/s10803-014-2213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4063-4063[article] Erratum to: Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study [Texte imprimé et/ou numérique] / Alexandra P. KEY, Auteur ; Lisa V. IBANEZ, Auteur ; Heather A. HENDERSON, Auteur ; Zachary WARREN, Auteur ; Daniel S. MESSINGER, Auteur ; Wendy L. STONE, Auteur . - p.4063-4063.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4063-4063
Index. décimale : PER Périodiques Résumé : Few behavioral indices of risk for autism spectrum disorders (ASD) are present before 12 months, and potential biomarkers remain largely unexamined. This prospective study of infant siblings of children with ASD (n = 16) and low-risk comparison infants (n = 15) examined group differences in event-related potentials (ERPs) indexing processing of facial positive affect (N290/P400, Nc) at 9 months and their relation to joint attention at 15 months. Group differences were most pronounced for subtle facial expressions, in that the low-risk group exhibited relatively longer processing (P400 latency) and greater attention resource allocation (Nc amplitude). Exploratory analyses found associations between ERP responses and later joint attention, suggesting that attention to positive affect cues may support the development of other social competencies. En ligne : http://dx.doi.org/10.1007/s10803-014-2213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 Improvement in Social Competence Using a Randomized Trial of a Theatre Intervention for Children with Autism Spectrum Disorder / Blythe A. CORBETT in Journal of Autism and Developmental Disorders, 46-2 (February 2016)
[article]
Titre : Improvement in Social Competence Using a Randomized Trial of a Theatre Intervention for Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Lydia QUALLS, Auteur ; Stephanie FECTEAU, Auteur ; Cassandra NEWSOM, Auteur ; Catherine COKE, Auteur ; Paul J. YODER, Auteur Année de publication : 2016 Article en page(s) : p.658-672 Langues : Anglais (eng) Mots-clés : Autism Theatre Social competence Faces Cognition ERP Index. décimale : PER Périodiques Résumé : The efficacy of a peer-mediated, theatre-based intervention on social competence in participants with autism spectrum disorder (ASD) was tested. Thirty 8-to-14 year-olds with ASD were randomly assigned to the treatment (n = 17) or a wait-list control (n = 13) group. Immediately after treatment, group effects were seen on social ability, (d = .77), communication symptoms (d = ?.86), group play with toys in the company of peers (d = .77), immediate memory of faces as measured by neuropsychological (d = .75) and ERP methods (d = .93), delayed memory for faces (d = .98), and theory of mind (d = .99). At the 2 month follow-up period, group effects were detected on communication symptoms (d = .82). The results of this pilot clinical trial provide initial support for the efficacy of the theatre-based intervention. En ligne : http://dx.doi.org/10.1007/s10803-015-2600-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.658-672[article] Improvement in Social Competence Using a Randomized Trial of a Theatre Intervention for Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Lydia QUALLS, Auteur ; Stephanie FECTEAU, Auteur ; Cassandra NEWSOM, Auteur ; Catherine COKE, Auteur ; Paul J. YODER, Auteur . - 2016 . - p.658-672.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.658-672
Mots-clés : Autism Theatre Social competence Faces Cognition ERP Index. décimale : PER Périodiques Résumé : The efficacy of a peer-mediated, theatre-based intervention on social competence in participants with autism spectrum disorder (ASD) was tested. Thirty 8-to-14 year-olds with ASD were randomly assigned to the treatment (n = 17) or a wait-list control (n = 13) group. Immediately after treatment, group effects were seen on social ability, (d = .77), communication symptoms (d = ?.86), group play with toys in the company of peers (d = .77), immediate memory of faces as measured by neuropsychological (d = .75) and ERP methods (d = .93), delayed memory for faces (d = .98), and theory of mind (d = .99). At the 2 month follow-up period, group effects were detected on communication symptoms (d = .82). The results of this pilot clinical trial provide initial support for the efficacy of the theatre-based intervention. En ligne : http://dx.doi.org/10.1007/s10803-015-2600-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study / Alexandra P. KEY in Journal of Autism and Developmental Disorders, 45-12 (December 2015)
[article]
Titre : Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra P. KEY, Auteur ; Lisa V. IBANEZ, Auteur ; Heather A. HENDERSON, Auteur ; Zachary WARREN, Auteur ; Daniel S. MESSINGER, Auteur ; Wendy L. STONE, Auteur Année de publication : 2015 Article en page(s) : p.4051-4062 Langues : Anglais (eng) Mots-clés : Autism ERP Face Infant Joint attention Positive affect Risk Index. décimale : PER Périodiques Résumé : Few behavioral indices of risk for autism spectrum disorders (ASD) are present before 12 months, and potential biomarkers remain largely unexamined. This prospective study of infant siblings of children with ASD (n = 16) and low-risk comparison infants (n = 15) examined group differences in event-related potentials (ERPs) indexing processing of facial positive affect (N290/P400, Nc) at 9 months and their relation to joint attention at 15 months. Group differences were most pronounced for subtle facial expressions, in that the low-risk group exhibited relatively longer processing (P400 latency) and greater attention resource allocation (Nc amplitude). Exploratory analyses found associations between ERP responses and later joint attention, suggesting that attention to positive affect cues may support the development of other social competencies. En ligne : http://dx.doi.org/10.1007/s10803-014-2191-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4051-4062[article] Positive Affect Processing and Joint Attention in Infants at High Risk for Autism: An Exploratory Study [Texte imprimé et/ou numérique] / Alexandra P. KEY, Auteur ; Lisa V. IBANEZ, Auteur ; Heather A. HENDERSON, Auteur ; Zachary WARREN, Auteur ; Daniel S. MESSINGER, Auteur ; Wendy L. STONE, Auteur . - 2015 . - p.4051-4062.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4051-4062
Mots-clés : Autism ERP Face Infant Joint attention Positive affect Risk Index. décimale : PER Périodiques Résumé : Few behavioral indices of risk for autism spectrum disorders (ASD) are present before 12 months, and potential biomarkers remain largely unexamined. This prospective study of infant siblings of children with ASD (n = 16) and low-risk comparison infants (n = 15) examined group differences in event-related potentials (ERPs) indexing processing of facial positive affect (N290/P400, Nc) at 9 months and their relation to joint attention at 15 months. Group differences were most pronounced for subtle facial expressions, in that the low-risk group exhibited relatively longer processing (P400 latency) and greater attention resource allocation (Nc amplitude). Exploratory analyses found associations between ERP responses and later joint attention, suggesting that attention to positive affect cues may support the development of other social competencies. En ligne : http://dx.doi.org/10.1007/s10803-014-2191-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder / Alexandra P. KEY in Autism Research, 15-4 (April 2022)
[article]
Titre : Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra P. KEY, Auteur ; Dorita JONES, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.712-728 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Child Emotional Regulation Emotions/physiology Evoked Potentials/physiology Facial Expression Female Humans Male Sex Characteristics autism emotion face inhibition sex target detection Index. décimale : PER Périodiques Résumé : Autism may be underdiagnosed in females because their social difficulties are often less noticeable. This study explored sex differences in automatic facial emotion processing in 45 adolescents with autism spectrum disorder (22 female, 23 male), age 10-16?years, performing active target detection task and Go/NoGo tasks where faces with positive and negative emotional expressions served as irrelevant distractors. The combined sample demonstrated more accurate performance on the target detection (response initiation) than the Go/NoGo task (response inhibition), replicating findings previously reported in typical participants. Females exhibited greater difficulty than males with response initiation in the target detection task, especially in the context of angry faces, while males found withholding a response in the Go/NoGo block with happy faces more challenging. Electrophysiological data revealed no sex differences or emotion discrimination effects during the early perceptual processing of faces indexed by the occipitotemporal N170. Autistic males demonstrated increased frontal N2 and parietal P3 amplitudes compared to females, suggesting greater neural resource allocation to automatic emotion regulation processes. The associations between standardized behavioral measures (autism severity, theory of mind skills) and brain responses also varied by sex: more adaptive social functioning was related to the speed of perceptual processing (N170 latency) in females and the extent of deliberate attention allocation (P3 amplitudes) in males. Together, these findings suggest that males and females with autism may rely on different strategies for social functioning and highlight the importance of considering sex differences in autism. LAY SUMMARY: Females with autism may exhibit less noticeable social difficulties than males. This study demonstrates that autistic females are more successful than males at inhibiting behavioral responses in emotional contexts, while males are more likely to initiate a response. At the neural level, social functioning in females is related to the speed of automatic perceptual processing of facial cues, and in males, to the extent of active attention allocation to the stimuli. These findings highlight the importance of considering sex differences in autism diagnosis and treatment selection. En ligne : https://dx.doi.org/10.1002/aur.2678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-4 (April 2022) . - p.712-728[article] Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Alexandra P. KEY, Auteur ; Dorita JONES, Auteur ; Blythe A. CORBETT, Auteur . - p.712-728.
Langues : Anglais (eng)
in Autism Research > 15-4 (April 2022) . - p.712-728
Mots-clés : Adolescent Autism Spectrum Disorder Child Emotional Regulation Emotions/physiology Evoked Potentials/physiology Facial Expression Female Humans Male Sex Characteristics autism emotion face inhibition sex target detection Index. décimale : PER Périodiques Résumé : Autism may be underdiagnosed in females because their social difficulties are often less noticeable. This study explored sex differences in automatic facial emotion processing in 45 adolescents with autism spectrum disorder (22 female, 23 male), age 10-16?years, performing active target detection task and Go/NoGo tasks where faces with positive and negative emotional expressions served as irrelevant distractors. The combined sample demonstrated more accurate performance on the target detection (response initiation) than the Go/NoGo task (response inhibition), replicating findings previously reported in typical participants. Females exhibited greater difficulty than males with response initiation in the target detection task, especially in the context of angry faces, while males found withholding a response in the Go/NoGo block with happy faces more challenging. Electrophysiological data revealed no sex differences or emotion discrimination effects during the early perceptual processing of faces indexed by the occipitotemporal N170. Autistic males demonstrated increased frontal N2 and parietal P3 amplitudes compared to females, suggesting greater neural resource allocation to automatic emotion regulation processes. The associations between standardized behavioral measures (autism severity, theory of mind skills) and brain responses also varied by sex: more adaptive social functioning was related to the speed of perceptual processing (N170 latency) in females and the extent of deliberate attention allocation (P3 amplitudes) in males. Together, these findings suggest that males and females with autism may rely on different strategies for social functioning and highlight the importance of considering sex differences in autism. LAY SUMMARY: Females with autism may exhibit less noticeable social difficulties than males. This study demonstrates that autistic females are more successful than males at inhibiting behavioral responses in emotional contexts, while males are more likely to initiate a response. At the neural level, social functioning in females is related to the speed of automatic perceptual processing of facial cues, and in males, to the extent of active attention allocation to the stimuli. These findings highlight the importance of considering sex differences in autism diagnosis and treatment selection. En ligne : https://dx.doi.org/10.1002/aur.2678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473