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Auteur Rachael A. MUSCATELLO |
Documents disponibles écrits par cet auteur (7)
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Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder / E. Kale EDMISTON in Research in Autism Spectrum Disorders, 36 (April 2017)
[article]
Titre : Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. Kale EDMISTON, Auteur ; Rachael A. MUSCATELLO, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.57-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Pre-ejection period Social evaluative threat Adolescence Social behavior Index. décimale : PER Périodiques Résumé : The autonomic nervous system (ANS) is involved in regulating social behavior; Autism Spectrum Disorder (ASD) is characterized by alterations in social behavior and reduced physiological response to threat. We hypothesized that adolescents with ASD would show reduced ANS response to social threat. Methods Eighteen males with ASD and thirteen males with typical development (TD), ages 12 to 17, completed a social threat paradigm while wearing an impedance cardiography apparatus. We calculated pre-ejection period (PEP) and tested for between-group differences in PEP response to social threat. We also conducted correlation analyses between PEP change scores and clinical symptom scales. Results There was an effect of diagnosis on change in PEP from baseline to the onset of social threat (F = 7.60, p = 0.01), with greater changes in PEP in TD compared to ASD. PEP change score and the Social Communication Questionnaire (r = 0.634, p = 0.005) and the ADHD Problems Subscale of the Child Behavior Checklist (r = 0.568, p = 0.014) were correlated. These findings suggest reduced arousal in response to social threat in ASD, with preliminary evidence that reduced sympathetic activation is associated with increased social behavior symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Research in Autism Spectrum Disorders > 36 (April 2017) . - p.57-65[article] Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / E. Kale EDMISTON, Auteur ; Rachael A. MUSCATELLO, Auteur ; Blythe A. CORBETT, Auteur . - p.57-65.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 36 (April 2017) . - p.57-65
Mots-clés : Autism spectrum disorder Pre-ejection period Social evaluative threat Adolescence Social behavior Index. décimale : PER Périodiques Résumé : The autonomic nervous system (ANS) is involved in regulating social behavior; Autism Spectrum Disorder (ASD) is characterized by alterations in social behavior and reduced physiological response to threat. We hypothesized that adolescents with ASD would show reduced ANS response to social threat. Methods Eighteen males with ASD and thirteen males with typical development (TD), ages 12 to 17, completed a social threat paradigm while wearing an impedance cardiography apparatus. We calculated pre-ejection period (PEP) and tested for between-group differences in PEP response to social threat. We also conducted correlation analyses between PEP change scores and clinical symptom scales. Results There was an effect of diagnosis on change in PEP from baseline to the onset of social threat (F = 7.60, p = 0.01), with greater changes in PEP in TD compared to ASD. PEP change score and the Social Communication Questionnaire (r = 0.634, p = 0.005) and the ADHD Problems Subscale of the Child Behavior Checklist (r = 0.568, p = 0.014) were correlated. These findings suggest reduced arousal in response to social threat in ASD, with preliminary evidence that reduced sympathetic activation is associated with increased social behavior symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study / Rachael A. MUSCATELLO in Journal of Autism and Developmental Disorders, 53-9 (September 2023)
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Titre : Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Aaron PACHOL, Auteur ; Alexandra ROMINES, Auteur ; Ian SMITH, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.3613-3626 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prolonged dysregulation of the autonomic nervous system (ANS) may increase propensity for physical or psychiatric illness. The current study examined differences in respiratory sinus arrhythmia (RSA) regulation in 215 adolescents with or without autism spectrum disorder (ASD) at Time 1 (T1; 10-13 years old) and 1 year later (Time 2; T2). Linear mixed effects models demonstrated lower RSA regulation in ASD, and a small interaction effect, showing blunted change in RSA from T1 to T2. Developmental differences in RSA regulation were particularly notable in females with ASD and those taking psychotropic medications. Results expand previous findings of reduced parasympathetic regulation in ASD by revealing a blunted developmental slope, indicating diagnostic differences may persist or worsen over time, particularly in females. En ligne : https://doi.org/10.1007/s10803-022-05664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511
in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3613-3626[article] Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Aaron PACHOL, Auteur ; Alexandra ROMINES, Auteur ; Ian SMITH, Auteur ; Blythe A. CORBETT, Auteur . - p.3613-3626.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3613-3626
Index. décimale : PER Périodiques Résumé : Prolonged dysregulation of the autonomic nervous system (ANS) may increase propensity for physical or psychiatric illness. The current study examined differences in respiratory sinus arrhythmia (RSA) regulation in 215 adolescents with or without autism spectrum disorder (ASD) at Time 1 (T1; 10-13 years old) and 1 year later (Time 2; T2). Linear mixed effects models demonstrated lower RSA regulation in ASD, and a small interaction effect, showing blunted change in RSA from T1 to T2. Developmental differences in RSA regulation were particularly notable in females with ASD and those taking psychotropic medications. Results expand previous findings of reduced parasympathetic regulation in ASD by revealing a blunted developmental slope, indicating diagnostic differences may persist or worsen over time, particularly in females. En ligne : https://doi.org/10.1007/s10803-022-05664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder / Rachael A. MUSCATELLO in Journal of Autism and Developmental Disorders, 52-8 (August 2022)
[article]
Titre : Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.3427-3442 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/diagnosis Autonomic Nervous System Humans Autonomic Obesity Parasympathetic Puberty Stress no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13Â years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442[article] Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur . - p.3427-3442.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442
Mots-clés : Adolescent Autism Spectrum Disorder/diagnosis Autonomic Nervous System Humans Autonomic Obesity Parasympathetic Puberty Stress no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13Â years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth / Blythe A. CORBETT in Autism Research, 15-10 (October 2022)
[article]
Titre : Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur Article en page(s) : p.1894-1908 Langues : Anglais (eng) Mots-clés : adolescence autism development female puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-10 (October 2022) . - p.1894-1908[article] Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur . - p.1894-1908.
Langues : Anglais (eng)
in Autism Research > 15-10 (October 2022) . - p.1894-1908
Mots-clés : adolescence autism development female puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Greater gender diversity among autistic children by self-report and parent-report / Blythe A. CORBETT in Autism, 27-1 (January 2023)
[article]
Titre : Greater gender diversity among autistic children by self-report and parent-report Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Mark E. KLEMENCIC, Auteur ; Millicent WEST, Auteur ; Ahra KIM, Auteur ; John F. STRANG, Auteur Article en page(s) : p.158-172 Langues : Anglais (eng) Mots-clés : autism spectrum disorder gender diversity gender dysphoria gender incongruence gender nonbinary Index. décimale : PER Périodiques Résumé : Emerging research suggests overrepresentation of gender diversity among autistic youth. Previous gender diversity research with autistic children has relied on parent-report based on a single question. The Gender Diversity Screening Questionnaire-Self-Report and Parent-Report assessed gender diversity experiences from 244 children (140 autism spectrum disorder and 104 typically developing), between 10 and 13 years, and their parents. Parent-report Child Behavior Checklist Item-110, œWishes to be the opposite sex, was also collected. Autistic children endorsed higher Gender Diversity Screening Questionnaire-Self-Report Binary Gender Diversity, t(223.21)=-2.83, adjusted p=0.02, d=-0.35, and Nonbinary Gender Diversity, t(191.15)=-3.79, adjusted p=0.001, d=-0.46, than typically developing children. Similarly, for Gender Diversity Screening Questionnaire-Parent-Report, there was a significant gender-body incongruence difference between the groups, t(189.59)=-2.28, adjusted p=0.05, d=-0.30. Within-group analyses revealed that parents of autistic females-assigned-at-birth reported significantly more gender-body incongruence than males-assigned-at-birth, t(32.91)=-3.78, p < 0.001, d=-1.11. Moreover, distinct within-group profiles of gender experiences and internalizing symptoms were revealed, showing associations between gender profiles and symptoms of anxiety, depression, and suicidality. Results extend reports showing increased rates of gender diversity in autistic children based on both self-report and parent-report, underscoring the need to better understand and support the unique and complex needs of autistic children who experience gender diversity. Lay abstract Gender diversity broadly refers to the way in which an individual experiences (expressions and/or identities) their gender distinctly to that which would be expected based upon social norms for their gender assigned at birth. Recent research has shown a higher representation of gender diversity among autistic youth. Previous research in this area has relied on parent-report based on a single question from the Child Behavior Checklist Item-110, asking whether their child œWishes to be the opposite sex. The Gender Diversity Screening Questionnaire Self-Report and Parent-Report were used to assess the experience of gender diversity in 244 children (140 autism spectrum disorder and 104 typically developing) between 10 and 13 years. The Item-110 was also collected. Results showed that autistic children endorsed much higher rates of Binary Gender Diversity (less identification with their designated sex and more with the other binary sex) and Nonbinary Gender Diversity (identification as neither male nor female) than typically developing children. Similarly, parents of autistic children reported significantly more gender-body incongruence experienced by their child than parents of typically developing children. Specifically, parents of autistic females-assigned-at-birth reported significantly more gender-body incongruence than autistic males-assigned-at-birth. Parent- and self-report measures were largely related. Moreover, statistical comparisons between and within the groups revealed associations between gender profiles and symptoms of anxiety, depression, and suicidality. Results extend previous reports showing increased rates of gender diversity in autistic children, now based on both self-report and parent-report, and highlight the need to better understand and support the unique and complex needs of autistic children who experience gender diversity. En ligne : http://dx.doi.org/10.1177/13623613221085337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Autism > 27-1 (January 2023) . - p.158-172[article] Greater gender diversity among autistic children by self-report and parent-report [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Mark E. KLEMENCIC, Auteur ; Millicent WEST, Auteur ; Ahra KIM, Auteur ; John F. STRANG, Auteur . - p.158-172.
Langues : Anglais (eng)
in Autism > 27-1 (January 2023) . - p.158-172
Mots-clés : autism spectrum disorder gender diversity gender dysphoria gender incongruence gender nonbinary Index. décimale : PER Périodiques Résumé : Emerging research suggests overrepresentation of gender diversity among autistic youth. Previous gender diversity research with autistic children has relied on parent-report based on a single question. The Gender Diversity Screening Questionnaire-Self-Report and Parent-Report assessed gender diversity experiences from 244 children (140 autism spectrum disorder and 104 typically developing), between 10 and 13 years, and their parents. Parent-report Child Behavior Checklist Item-110, œWishes to be the opposite sex, was also collected. Autistic children endorsed higher Gender Diversity Screening Questionnaire-Self-Report Binary Gender Diversity, t(223.21)=-2.83, adjusted p=0.02, d=-0.35, and Nonbinary Gender Diversity, t(191.15)=-3.79, adjusted p=0.001, d=-0.46, than typically developing children. Similarly, for Gender Diversity Screening Questionnaire-Parent-Report, there was a significant gender-body incongruence difference between the groups, t(189.59)=-2.28, adjusted p=0.05, d=-0.30. Within-group analyses revealed that parents of autistic females-assigned-at-birth reported significantly more gender-body incongruence than males-assigned-at-birth, t(32.91)=-3.78, p < 0.001, d=-1.11. Moreover, distinct within-group profiles of gender experiences and internalizing symptoms were revealed, showing associations between gender profiles and symptoms of anxiety, depression, and suicidality. Results extend reports showing increased rates of gender diversity in autistic children based on both self-report and parent-report, underscoring the need to better understand and support the unique and complex needs of autistic children who experience gender diversity. Lay abstract Gender diversity broadly refers to the way in which an individual experiences (expressions and/or identities) their gender distinctly to that which would be expected based upon social norms for their gender assigned at birth. Recent research has shown a higher representation of gender diversity among autistic youth. Previous research in this area has relied on parent-report based on a single question from the Child Behavior Checklist Item-110, asking whether their child œWishes to be the opposite sex. The Gender Diversity Screening Questionnaire Self-Report and Parent-Report were used to assess the experience of gender diversity in 244 children (140 autism spectrum disorder and 104 typically developing) between 10 and 13 years. The Item-110 was also collected. Results showed that autistic children endorsed much higher rates of Binary Gender Diversity (less identification with their designated sex and more with the other binary sex) and Nonbinary Gender Diversity (identification as neither male nor female) than typically developing children. Similarly, parents of autistic children reported significantly more gender-body incongruence experienced by their child than parents of typically developing children. Specifically, parents of autistic females-assigned-at-birth reported significantly more gender-body incongruence than autistic males-assigned-at-birth. Parent- and self-report measures were largely related. Moreover, statistical comparisons between and within the groups revealed associations between gender profiles and symptoms of anxiety, depression, and suicidality. Results extend previous reports showing increased rates of gender diversity in autistic children, now based on both self-report and parent-report, and highlight the need to better understand and support the unique and complex needs of autistic children who experience gender diversity. En ligne : http://dx.doi.org/10.1177/13623613221085337 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis / Rachael A. MUSCATELLO in Molecular Autism, 13 (2022)
PermalinkSocial context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder / Rachael A. MUSCATELLO in Research in Autism Spectrum Disorders, 112 (April 2024)
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