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Auteur Maartje P. C. M. LUIJK |
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Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation / Rosa H. MULDER in Development and Psychopathology, 29-2 (May 2017)
[article]
Titre : Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation Type de document : Texte imprimé et/ou numérique Auteurs : Rosa H. MULDER, Auteur ; Jolien RIJLAARSDAM, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Frank C. VERHULST, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur Article en page(s) : p.491-503 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The parent–child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenal axis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity. En ligne : http://dx.doi.org/10.1017/s095457941700013x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305
in Development and Psychopathology > 29-2 (May 2017) . - p.491-503[article] Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation [Texte imprimé et/ou numérique] / Rosa H. MULDER, Auteur ; Jolien RIJLAARSDAM, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Frank C. VERHULST, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur . - p.491-503.
Langues : Anglais (eng)
in Development and Psychopathology > 29-2 (May 2017) . - p.491-503
Index. décimale : PER Périodiques Résumé : The parent–child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenal axis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity. En ligne : http://dx.doi.org/10.1017/s095457941700013x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305