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Détail de l'auteur
Auteur Khaled SAAD |
Documents disponibles écrits par cet auteur (3)
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Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders / Khaled SAAD in Journal of Autism and Developmental Disorders, 47-9 (September 2017)
[article]
Titre : Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Khaled SAAD, Auteur ; Asmaa M. ZAHRAN, Auteur ; Khalid I. ELSAYH, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Almontaser HUSSEIN, Auteur ; Yasmin G. EL-GENDY, Auteur Article en page(s) : p.2671-2678 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Dendritic cells Innate immunity Children Index. décimale : PER Périodiques Résumé : The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined. En ligne : https://doi.org/10.1007/s10803-017-3190-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315
in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2671-2678[article] Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Khaled SAAD, Auteur ; Asmaa M. ZAHRAN, Auteur ; Khalid I. ELSAYH, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Almontaser HUSSEIN, Auteur ; Yasmin G. EL-GENDY, Auteur . - p.2671-2678.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2671-2678
Mots-clés : Autism spectrum disorders Dendritic cells Innate immunity Children Index. décimale : PER Périodiques Résumé : The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined. En ligne : https://doi.org/10.1007/s10803-017-3190-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder / Khaled SAAD in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)
[article]
Titre : Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A. K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur Article en page(s) : p.20-29 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder vitamin D children clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29[article] Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A. K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur . - p.20-29.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29
Mots-clés : Autism spectrum disorder vitamin D children clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 Response to letters: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder – correction and additional information / Khaled SAAD in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)
[article]
Titre : Response to letters: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder – correction and additional information Type de document : Texte imprimé et/ou numérique Auteurs : Khaled SAAD, Auteur Article en page(s) : p.e3-e5 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.e3-e5[article] Response to letters: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder – correction and additional information [Texte imprimé et/ou numérique] / Khaled SAAD, Auteur . - p.e3-e5.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.e3-e5
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327