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Détail de l'auteur
Auteur Emily WOOD |
Documents disponibles écrits par cet auteur (2)
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Executive function and functional and structural brain differences in middle-age adults with autism spectrum disorder / B. Blair BRADEN in Autism Research, 10-12 (December 2017)
[article]
Titre : Executive function and functional and structural brain differences in middle-age adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : B. Blair BRADEN, Auteur ; Christopher J. SMITH, Auteur ; Amiee THOMPSON, Auteur ; Tyler K. GLASPY, Auteur ; Emily WOOD, Auteur ; Divya VATSA, Auteur ; Angela E. ABBOTT, Auteur ; Samuel C. MCGEE, Auteur ; Leslie C. BAXTER, Auteur Article en page(s) : p.1945-1959 Langues : Anglais (eng) Mots-clés : autism aging executive function magnetic resonance imaging (MRI) functional connectivity diffusion tensor imaging hippocampus working memory Index. décimale : PER Périodiques Résumé : There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n?=?16; NT, n?=?17) aged 40–64 years were well-matched according to age, IQ (range: 83–131), and education (range: 9–20 years). Middle-age adults with ASD made more errors on an executive function task (Wisconsin Card Sorting Test) but performed similarly to NT adults on tests of delayed verbal memory (Rey Auditory Verbal Learning Test) and local visual search (Embedded Figures Task). Independent component analysis of a functional MRI working memory task (n-back) completed by most participants (ASD?=?14, NT?=?17) showed decreased engagement of a cortico-striatal-thalamic-cortical neural network in older adults with ASD. Structurally, older adults with ASD had reduced bilateral hippocampal volumes, as measured by FreeSurfer. Findings expand our understanding of ASD as a lifelong condition with persistent cognitive and functional and structural brain differences evident at middle-age. Autism Res 2017, 10: 1945–1959. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We compared cognitive abilities and brain measures between 16 middle-age men with high-functioning autism spectrum disorder (ASD) and 17 typical middle-age men to better understand how aging affects an older group of adults with ASD. Men with ASD made more errors on a test involving flexible thinking, had less activity in a flexible thinking brain network, and had smaller volume of a brain structure related to memory than typical men. We will follow these older adults over time to determine if aging changes are greater for individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1842 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323
in Autism Research > 10-12 (December 2017) . - p.1945-1959[article] Executive function and functional and structural brain differences in middle-age adults with autism spectrum disorder [Texte imprimé et/ou numérique] / B. Blair BRADEN, Auteur ; Christopher J. SMITH, Auteur ; Amiee THOMPSON, Auteur ; Tyler K. GLASPY, Auteur ; Emily WOOD, Auteur ; Divya VATSA, Auteur ; Angela E. ABBOTT, Auteur ; Samuel C. MCGEE, Auteur ; Leslie C. BAXTER, Auteur . - p.1945-1959.
Langues : Anglais (eng)
in Autism Research > 10-12 (December 2017) . - p.1945-1959
Mots-clés : autism aging executive function magnetic resonance imaging (MRI) functional connectivity diffusion tensor imaging hippocampus working memory Index. décimale : PER Périodiques Résumé : There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n?=?16; NT, n?=?17) aged 40–64 years were well-matched according to age, IQ (range: 83–131), and education (range: 9–20 years). Middle-age adults with ASD made more errors on an executive function task (Wisconsin Card Sorting Test) but performed similarly to NT adults on tests of delayed verbal memory (Rey Auditory Verbal Learning Test) and local visual search (Embedded Figures Task). Independent component analysis of a functional MRI working memory task (n-back) completed by most participants (ASD?=?14, NT?=?17) showed decreased engagement of a cortico-striatal-thalamic-cortical neural network in older adults with ASD. Structurally, older adults with ASD had reduced bilateral hippocampal volumes, as measured by FreeSurfer. Findings expand our understanding of ASD as a lifelong condition with persistent cognitive and functional and structural brain differences evident at middle-age. Autism Res 2017, 10: 1945–1959. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We compared cognitive abilities and brain measures between 16 middle-age men with high-functioning autism spectrum disorder (ASD) and 17 typical middle-age men to better understand how aging affects an older group of adults with ASD. Men with ASD made more errors on a test involving flexible thinking, had less activity in a flexible thinking brain network, and had smaller volume of a brain structure related to memory than typical men. We will follow these older adults over time to determine if aging changes are greater for individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1842 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 The influence of age and ASD on verbal fluency networks / Leslie C. BAXTER in Research in Autism Spectrum Disorders, 63 (July 2019)
[article]
Titre : The influence of age and ASD on verbal fluency networks Type de document : Texte imprimé et/ou numérique Auteurs : Leslie C. BAXTER, Auteur ; Ashley NESPODZANY, Auteur ; M. J. M. WALSH, Auteur ; Emily WOOD, Auteur ; Christopher J. SMITH, Auteur ; B. Blair BRADEN, Auteur Article en page(s) : p.52-62 Langues : Anglais (eng) Mots-clés : ASD Aging fMRI Fluency Word generation Compensation Index. décimale : PER Périodiques Résumé : Background The integrity and connectivity of the frontal lobe, which subserves fluency, may be compromised by both ASD and aging. Alternate networks often integrate to help compensate for compromised functions during aging. We used network analyses to study how compensation may overcome age-related compromised in individuals with ASD. Method Participants consisted of middle-aged (40–60; n?=?24) or young (18–25; n?=?18) right-handed males who have a diagnosis of ASD, and age- and IQ-matched control participants (n?=?20, 14, respectively). All performed tests of language and executive functioning and a fluency functional MRI task. We first used group individual component analysis (ICA) for each of the 4 groups to determine whether different networks were engaged. An SPM analysis was used to compare activity detected in the network nodes from the ICA analyses. Results The individuals with ASD performed more slowly on two cognitive tasks (Stroop word reading and Trailmaking Part A). The 4 groups engaged different networks during the fluency fMRI task despite equivalent performance. Comparisons of specific regions within these networks indicated younger individuals had greater engagement of the thalamus and supplementary speech area, while older adults engaged the superior temporal gyrus. Individuals with ASD did not disengage from the Default Mode Network during word generation. Conclusion Interactions between diagnosis and aging were not found in this study of young and middle-aged men, but evidence for differential engagement of compensatory networks was observed. En ligne : https://doi.org/10.1016/j.rasd.2019.03.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394
in Research in Autism Spectrum Disorders > 63 (July 2019) . - p.52-62[article] The influence of age and ASD on verbal fluency networks [Texte imprimé et/ou numérique] / Leslie C. BAXTER, Auteur ; Ashley NESPODZANY, Auteur ; M. J. M. WALSH, Auteur ; Emily WOOD, Auteur ; Christopher J. SMITH, Auteur ; B. Blair BRADEN, Auteur . - p.52-62.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 63 (July 2019) . - p.52-62
Mots-clés : ASD Aging fMRI Fluency Word generation Compensation Index. décimale : PER Périodiques Résumé : Background The integrity and connectivity of the frontal lobe, which subserves fluency, may be compromised by both ASD and aging. Alternate networks often integrate to help compensate for compromised functions during aging. We used network analyses to study how compensation may overcome age-related compromised in individuals with ASD. Method Participants consisted of middle-aged (40–60; n?=?24) or young (18–25; n?=?18) right-handed males who have a diagnosis of ASD, and age- and IQ-matched control participants (n?=?20, 14, respectively). All performed tests of language and executive functioning and a fluency functional MRI task. We first used group individual component analysis (ICA) for each of the 4 groups to determine whether different networks were engaged. An SPM analysis was used to compare activity detected in the network nodes from the ICA analyses. Results The individuals with ASD performed more slowly on two cognitive tasks (Stroop word reading and Trailmaking Part A). The 4 groups engaged different networks during the fluency fMRI task despite equivalent performance. Comparisons of specific regions within these networks indicated younger individuals had greater engagement of the thalamus and supplementary speech area, while older adults engaged the superior temporal gyrus. Individuals with ASD did not disengage from the Default Mode Network during word generation. Conclusion Interactions between diagnosis and aging were not found in this study of young and middle-aged men, but evidence for differential engagement of compensatory networks was observed. En ligne : https://doi.org/10.1016/j.rasd.2019.03.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394