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Auteur A. MUNCHAU |
Documents disponibles écrits par cet auteur (2)
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Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome / V. PETRUO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)
[article]
Titre : Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : V. PETRUO, Auteur ; B. BODMER, Auteur ; V. C. BRANDT, Auteur ; L. BAUMUNG, Auteur ; V. ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur Article en page(s) : p.953-962 Langues : Anglais (eng) Mots-clés : Tourette syndrome cognitive control event related potential neurophysiology response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962[article] Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome [Texte imprimé et/ou numérique] / V. PETRUO, Auteur ; B. BODMER, Auteur ; V. C. BRANDT, Auteur ; L. BAUMUNG, Auteur ; V. ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur . - p.953-962.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962
Mots-clés : Tourette syndrome cognitive control event related potential neurophysiology response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism / O. FRUNDT in Journal of Autism and Developmental Disorders, 48-2 (February 2018)
[article]
Titre : White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur Article en page(s) : p.417-429 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Diffusion tensor imaging Fiber tracking Imitation Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429[article] White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism [Texte imprimé et/ou numérique] / O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur . - p.417-429.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429
Mots-clés : Autism spectrum disorders Diffusion tensor imaging Fiber tracking Imitation Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337