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Détail de l'auteur
Auteur G. DOLEN |
Documents disponibles écrits par cet auteur (1)
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Fragile x syndrome and autism: from disease model to therapeutic targets / G. DOLEN in Journal of Neurodevelopmental Disorders, 1-2 (June 2009)
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Titre : Fragile x syndrome and autism: from disease model to therapeutic targets Type de document : Texte imprimé et/ou numérique Auteurs : G. DOLEN, Auteur ; Mark F. BEAR, Auteur Article en page(s) : p.133-40 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS), one of the first identified and leading causes of autism, has been modeled in mice using molecular genetic manipulation. These Fmr1 knockout mice have recently been used to identify a new putative therapeutic target, the metabotropic glutamate receptor 5 (mGluR5), for the treatment of FXS. Moreover, mGluR5 signaling cascades interact with a number of synaptic proteins, many of which have been implicated in autism, raising the possibility that therapeutic targets identified for FXS may have efficacy in treating multiple other causes of autism. En ligne : http://dx.doi.org/10.1007/s11689-009-9015-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341
in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.133-40[article] Fragile x syndrome and autism: from disease model to therapeutic targets [Texte imprimé et/ou numérique] / G. DOLEN, Auteur ; Mark F. BEAR, Auteur . - p.133-40.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.133-40
Index. décimale : PER Périodiques Résumé : Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS), one of the first identified and leading causes of autism, has been modeled in mice using molecular genetic manipulation. These Fmr1 knockout mice have recently been used to identify a new putative therapeutic target, the metabotropic glutamate receptor 5 (mGluR5), for the treatment of FXS. Moreover, mGluR5 signaling cascades interact with a number of synaptic proteins, many of which have been implicated in autism, raising the possibility that therapeutic targets identified for FXS may have efficacy in treating multiple other causes of autism. En ligne : http://dx.doi.org/10.1007/s11689-009-9015-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341