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Détail de l'auteur
Auteur D. L. WILLIAMS |
Documents disponibles écrits par cet auteur (2)
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Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder / Laura E. QUIÑONES-CAMACHO in Autism Research, 14-8 (August 2021)
[article]
Titre : Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; F. A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; D. L. WILLIAMS, Auteur ; T. J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1585-1596 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Brain Brain Mapping Humans Mentalization Spectroscopy, Near-Infrared Asd Tpj neural synchrony social communication impairment social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1585-1596[article] Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder [Texte imprimé et/ou numérique] / Laura E. QUIÑONES-CAMACHO, Auteur ; F. A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; D. L. WILLIAMS, Auteur ; T. J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur . - p.1585-1596.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1585-1596
Mots-clés : Adult Autism Spectrum Disorder Brain Brain Mapping Humans Mentalization Spectroscopy, Near-Infrared Asd Tpj neural synchrony social communication impairment social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills / D. L. WILLIAMS in Journal of Autism and Developmental Disorders, 48-11 (November 2018)
[article]
Titre : Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills Type de document : Texte imprimé et/ou numérique Auteurs : D. L. WILLIAMS, Auteur ; M. SIEGEL, Auteur ; C. A. MAZEFSKY, Auteur Article en page(s) : p.3668-3677 Langues : Anglais (eng) Mots-clés : Autism inpatient collection (AIC) Autism spectrum disorder (ASD) Challenging behavior Communication Coping skills Psychiatric inpatients Index. décimale : PER Périodiques Résumé : Data from the Autism Inpatient Collection was used to examine the relationship between problem behaviors and verbal ability, which have generally, though not universally, been highly associated. In a comparison of 169 minimally-verbal and 177 fluently-verbal 4 to 20-year-old psychiatric inpatients with ASD, the severity of self-injurious behavior, stereotyped behavior, and irritability (including aggression and tantrums) did not significantly differ, when controlling for age and NVIQ. Verbal ability was not strongly related to the severity of problem behaviors. However, lower adapting/coping scores were significantly associated with increasing severity of each type of problem behavior, even when accounting for verbal ability. Interventions to develop adapting/coping mechanisms may be important for mitigation of problem behaviors across the spectrum of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370
in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3668-3677[article] Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills [Texte imprimé et/ou numérique] / D. L. WILLIAMS, Auteur ; M. SIEGEL, Auteur ; C. A. MAZEFSKY, Auteur . - p.3668-3677.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3668-3677
Mots-clés : Autism inpatient collection (AIC) Autism spectrum disorder (ASD) Challenging behavior Communication Coping skills Psychiatric inpatients Index. décimale : PER Périodiques Résumé : Data from the Autism Inpatient Collection was used to examine the relationship between problem behaviors and verbal ability, which have generally, though not universally, been highly associated. In a comparison of 169 minimally-verbal and 177 fluently-verbal 4 to 20-year-old psychiatric inpatients with ASD, the severity of self-injurious behavior, stereotyped behavior, and irritability (including aggression and tantrums) did not significantly differ, when controlling for age and NVIQ. Verbal ability was not strongly related to the severity of problem behaviors. However, lower adapting/coping scores were significantly associated with increasing severity of each type of problem behavior, even when accounting for verbal ability. Interventions to develop adapting/coping mechanisms may be important for mitigation of problem behaviors across the spectrum of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370