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Détail de l'auteur
Auteur A. GAMAN |
Documents disponibles écrits par cet auteur (2)
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Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / C. LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)
[article]
Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults Anterior cingulate cortex Autism Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409[article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [Texte imprimé et/ou numérique] / C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur . - p.1402-1409.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409
Mots-clés : Adults Anterior cingulate cortex Autism Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? / M. BENNABI in Molecular Autism, 10 (2019)
[article]
Titre : Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? Type de document : Texte imprimé et/ou numérique Auteurs : M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders High-functioning autism Natural killer cells Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Molecular Autism > 10 (2019) . - 22p.[article] Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? [Texte imprimé et/ou numérique] / M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur . - 22p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 22p.
Mots-clés : Autism spectrum disorders High-functioning autism Natural killer cells Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402