Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Abdalla M. EL MOWAFY |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Emerging Clues and Altered Metabolic Findings in Autism: Breakthroughs and Prospects from Omics Studies / Abdalla M. EL MOWAFY in Autism - Open Access, 6-1 ([01/01/2016])
[article]
Titre : Emerging Clues and Altered Metabolic Findings in Autism: Breakthroughs and Prospects from Omics Studies Type de document : Texte imprimé et/ou numérique Auteurs : Abdalla M. EL MOWAFY, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism (ASD) Emerging clues Etiology Biomarkers Altered metabolism Hypertestosteronemia Management Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive broad-spectrum disorder that involves multifaceted delays in the development of many basic, social, and communication skills. The etiology of ASD is multifactorial and involves interplay among genetic, neurologic, hormonal, metabolic, immune-inflammatory, and environmental factors; which further complicate both the diagnosis and management in affected individuals. This review delineates the underpinnings of clinical challenges posed by ASD, like clinical heterogeneity of patient presentation, unresolved ASD genomic map and deficient drug therapy. Besides, it addresses the emerging pathogenic, etiologic, and diagnostic clues of diverse origins, encompassing genetic-, neurotransmitter-, androgenic- and immune inflammatory-anomalies in ASD patients, as availed by advances in Omics technologies (like genomics and proteomics). Moreover, as unravelled by metabolomics studies, metabolic flaws that pertain to amino acids, fatty acids, mitochondrial anomalies, and oxidative-stress are highlighted and further correlated with the extent of clinical picture and mal behaviors coherent with ASD patients. Lastly, future directions are underlined to promote and rationalize ASD research so as to help translate its findings into remedy. En ligne : https://dx.doi.org/10.4172/2165-7890.1000166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 6-1 [01/01/2016] . - 8 p.[article] Emerging Clues and Altered Metabolic Findings in Autism: Breakthroughs and Prospects from Omics Studies [Texte imprimé et/ou numérique] / Abdalla M. EL MOWAFY, Auteur . - 8 p.
Langues : Anglais (eng)
in Autism - Open Access > 6-1 [01/01/2016] . - 8 p.
Mots-clés : Autism (ASD) Emerging clues Etiology Biomarkers Altered metabolism Hypertestosteronemia Management Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive broad-spectrum disorder that involves multifaceted delays in the development of many basic, social, and communication skills. The etiology of ASD is multifactorial and involves interplay among genetic, neurologic, hormonal, metabolic, immune-inflammatory, and environmental factors; which further complicate both the diagnosis and management in affected individuals. This review delineates the underpinnings of clinical challenges posed by ASD, like clinical heterogeneity of patient presentation, unresolved ASD genomic map and deficient drug therapy. Besides, it addresses the emerging pathogenic, etiologic, and diagnostic clues of diverse origins, encompassing genetic-, neurotransmitter-, androgenic- and immune inflammatory-anomalies in ASD patients, as availed by advances in Omics technologies (like genomics and proteomics). Moreover, as unravelled by metabolomics studies, metabolic flaws that pertain to amino acids, fatty acids, mitochondrial anomalies, and oxidative-stress are highlighted and further correlated with the extent of clinical picture and mal behaviors coherent with ASD patients. Lastly, future directions are underlined to promote and rationalize ASD research so as to help translate its findings into remedy. En ligne : https://dx.doi.org/10.4172/2165-7890.1000166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409