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Auteur Jing ZHANG |
Documents disponibles écrits par cet auteur (4)
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Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children / MacKinsey A. BACH in Research in Autism Spectrum Disorders, 76 (August 2020)
[article]
Titre : Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children Type de document : Texte imprimé et/ou numérique Auteurs : MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : p.101587 Langues : Anglais (eng) Mots-clés : Polychlorinated biphenyls (PCBs) Organochlorine (OC) pesticides Autism spectrum disorder (ASD) Glutathione S-transferase (GST) genes Interaction Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? 0.01). Discussion Differences in diet between ASD and typically developing control groups may play a role in the observed findings of lower concentrations of PCB-153 and PCB-180 in individuals with ASD than in controls. Considering the limited sample size and high proportion of concentrations below the LoD, these results should be interpreted with caution but warrant further investigation into associations of PCBs and OC pesticides with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101587[article] Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children [Texte imprimé et/ou numérique] / MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - p.101587.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101587
Mots-clés : Polychlorinated biphenyls (PCBs) Organochlorine (OC) pesticides Autism spectrum disorder (ASD) Glutathione S-transferase (GST) genes Interaction Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? 0.01). Discussion Differences in diet between ASD and typically developing control groups may play a role in the observed findings of lower concentrations of PCB-153 and PCB-180 in individuals with ASD than in controls. Considering the limited sample size and high proportion of concentrations below the LoD, these results should be interpreted with caution but warrant further investigation into associations of PCBs and OC pesticides with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Heterogeneous trajectories of suicidal ideation among homeless youth: predictors and suicide-related outcomes / Jing ZHANG ; Laura WALSH ; Natasha SLESNICK in Development and Psychopathology, 35-4 (October 2023)
[article]
Titre : Heterogeneous trajectories of suicidal ideation among homeless youth: predictors and suicide-related outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Jing ZHANG, Auteur ; Laura WALSH, Auteur ; Natasha SLESNICK, Auteur Article en page(s) : p.1671-1683 Langues : Anglais (eng) Mots-clés : cognitive therapy growth mixture modeling heterogenous treatment effects homeless youth person-centered approach suicidal ideation Index. décimale : PER Périodiques Résumé : The current study examined heterogeneous trajectories of suicidal ideation among homeless youth experiencing suicidal ideation over 9 months in a randomized controlled intervention study. Suicidal homeless youth (N = 150) were randomly assigned to Cognitive Therapy for Suicide Prevention (CTSP) + Treatment as Usual (TAU) or TAU alone. Youth reported their suicidal ideation four times during a 9-month period. We also assessed pretreatment mental health, demographic information and session attendance as predictors of the subgroups, as well as suicide-related factors as outcomes at the 9-month follow-up. Growth mixture models suggested three distinct trajectory groups among youth: Fast Declining (74.7%), Chronic (19.3%), and Steadily Declining (6.0%). Youth in the Chronic group used more substances at baseline than the Steadily Declining group, were more likely to be White, non-Hispanic than the Fast Declining group, and attended more CTSP sessions than other groups. Contrastingly, youth in the Steadily Declining group all experienced childhood abuse. Finally, youth in the Chronic group showed significant higher risk for future suicide compared to those in the Fast Declining group at 9 months. Findings support the heterogeneity of treatment responses in suicide intervention among homeless youth, with implications to improve treatment efforts in this very high-risk population. En ligne : https://dx.doi.org/10.1017/S0954579422000372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515
in Development and Psychopathology > 35-4 (October 2023) . - p.1671-1683[article] Heterogeneous trajectories of suicidal ideation among homeless youth: predictors and suicide-related outcomes [Texte imprimé et/ou numérique] / Jing ZHANG, Auteur ; Laura WALSH, Auteur ; Natasha SLESNICK, Auteur . - p.1671-1683.
Langues : Anglais (eng)
in Development and Psychopathology > 35-4 (October 2023) . - p.1671-1683
Mots-clés : cognitive therapy growth mixture modeling heterogenous treatment effects homeless youth person-centered approach suicidal ideation Index. décimale : PER Périodiques Résumé : The current study examined heterogeneous trajectories of suicidal ideation among homeless youth experiencing suicidal ideation over 9 months in a randomized controlled intervention study. Suicidal homeless youth (N = 150) were randomly assigned to Cognitive Therapy for Suicide Prevention (CTSP) + Treatment as Usual (TAU) or TAU alone. Youth reported their suicidal ideation four times during a 9-month period. We also assessed pretreatment mental health, demographic information and session attendance as predictors of the subgroups, as well as suicide-related factors as outcomes at the 9-month follow-up. Growth mixture models suggested three distinct trajectory groups among youth: Fast Declining (74.7%), Chronic (19.3%), and Steadily Declining (6.0%). Youth in the Chronic group used more substances at baseline than the Steadily Declining group, were more likely to be White, non-Hispanic than the Fast Declining group, and attended more CTSP sessions than other groups. Contrastingly, youth in the Steadily Declining group all experienced childhood abuse. Finally, youth in the Chronic group showed significant higher risk for future suicide compared to those in the Fast Declining group at 9 months. Findings support the heterogeneity of treatment responses in suicide intervention among homeless youth, with implications to improve treatment efforts in this very high-risk population. En ligne : https://dx.doi.org/10.1017/S0954579422000372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 79 (November 2020)
[article]
Titre : Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur Article en page(s) : 101681 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Glutathione S-transferase (GST) genes ( and ) Mixture analysis Generalized weighted quantile sum regression (gWQS) Heavy metals Jamaica Index. décimale : PER Périodiques Résumé : Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? 0.05) and [MOR (95 % CI) = 0.46 (0.25, 0.84); P = 0.01], respectively. In an unadjusted negative gWQS model, we found a marginally significant interaction between GSTP1 and a mixture of three metals (Pb, Hg, and Mn) (P = 0.07) while the association was no longer significant after adjustment for the same covariates (P = 0.24). Conclusions Differences in diet between ASD and control groups may play a role in the inverse associations we found. The possible interactive association between Mn and GSTP1 in ASD based on gWQS is consistent with our previous reports. However, possible interaction of GSTP1 with Pb and Hg in ASD requires further investigation and replication. En ligne : https://doi.org/10.1016/j.rasd.2020.101681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101681[article] Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur . - 101681.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101681
Mots-clés : Autism Spectrum Disorder Glutathione S-transferase (GST) genes ( and ) Mixture analysis Generalized weighted quantile sum regression (gWQS) Heavy metals Jamaica Index. décimale : PER Périodiques Résumé : Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? 0.05) and [MOR (95 % CI) = 0.46 (0.25, 0.84); P = 0.01], respectively. In an unadjusted negative gWQS model, we found a marginally significant interaction between GSTP1 and a mixture of three metals (Pb, Hg, and Mn) (P = 0.07) while the association was no longer significant after adjustment for the same covariates (P = 0.24). Conclusions Differences in diet between ASD and control groups may play a role in the inverse associations we found. The possible interactive association between Mn and GSTP1 in ASD based on gWQS is consistent with our previous reports. However, possible interaction of GSTP1 with Pb and Hg in ASD requires further investigation and replication. En ligne : https://doi.org/10.1016/j.rasd.2020.101681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 The relationship between autism spectrum and sleep-wake traits / Stacey D. ELKHATIB SMIDT in Autism Research, 15-4 (April 2022)
[article]
Titre : The relationship between autism spectrum and sleep-wake traits Type de document : Texte imprimé et/ou numérique Auteurs : Stacey D. ELKHATIB SMIDT, Auteur ; Arpita GHORAI, Auteur ; Sara C TAYLOR, Auteur ; Brielle N. GEHRINGER, Auteur ; Holly C. DOW, Auteur ; Allison LANGER, Auteur ; Eric RAWOT, Auteur ; Jing ZHANG, Auteur ; Jonathan A. MITCHELL, Auteur ; Daniel J. RADER, Auteur ; Laura ALMASY, Auteur ; Edward S. BRODKIN, Auteur ; Maja BU?AN, Auteur Article en page(s) : p.641-652 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/complications Autistic Disorder/complications Child Humans Quality of Life Sleep Sleep Wake Disorders/complications adults autism spectrum disorder children executive function Index. décimale : PER Périodiques Résumé : Autistic children and adults often have sleep disturbances, which may affect their and their family's quality of life. Yet, the relationship between sleep-wake patterns and autism spectrum traits is understudied. Identifying such relationships could lead to future research elucidating common mechanistic underpinnings. Thus, we aimed to determine whether sleep-wake patterns, specifically related to sleep, physical activity, and the daily sleep-wake rhythm (i.e., circadian rhythm), are associated with autism spectrum-related traits. Accelerometer-derived sleep-wake parameters were estimated in individuals with autistic spectrum traits and their family members (N = 267). We evaluated autism spectrum traits using the Social Responsiveness Scale (SRS) to assess the presence and severity of social impairment and the Behavior Rating Inventory of Executive Function (BRIEF) to assess executive function. The linear multivariate regression analysis (using SOLAR-Eclipse) showed that in adults, increased core autism spectrum traits and executive dysfunction were associated with disruption of several sleep-wake parameters, particularly related to the daily sleep-wake rhythm, and that executive dysfunction was associated with disrupted sleep quality and level of physical activity. We highlight the interplay between daytime function and disrupted sleep-wake patterns, specifically related to the daily sleep-wake rhythm, that could guide future research into common mechanisms. LAY SUMMARY: Autistic children and adults often report sleep disturbances. To dissect the relationship between a range of autism spectrum traits and sleep-wake patterns, we assessed social interaction and executive function in participants who also wore actimetry watches on their wrists to assess their sleep-wake patterns. We found that increased impairments in social and executive function occurred with increased sleep-wake disturbances, particularly those related to the circadian rhythm, suggesting that these perturbations/disruptions in the sleep-wake cycle could be connected to autism spectrum traits. En ligne : https://dx.doi.org/10.1002/aur.2660 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-4 (April 2022) . - p.641-652[article] The relationship between autism spectrum and sleep-wake traits [Texte imprimé et/ou numérique] / Stacey D. ELKHATIB SMIDT, Auteur ; Arpita GHORAI, Auteur ; Sara C TAYLOR, Auteur ; Brielle N. GEHRINGER, Auteur ; Holly C. DOW, Auteur ; Allison LANGER, Auteur ; Eric RAWOT, Auteur ; Jing ZHANG, Auteur ; Jonathan A. MITCHELL, Auteur ; Daniel J. RADER, Auteur ; Laura ALMASY, Auteur ; Edward S. BRODKIN, Auteur ; Maja BU?AN, Auteur . - p.641-652.
Langues : Anglais (eng)
in Autism Research > 15-4 (April 2022) . - p.641-652
Mots-clés : Adult Autism Spectrum Disorder/complications Autistic Disorder/complications Child Humans Quality of Life Sleep Sleep Wake Disorders/complications adults autism spectrum disorder children executive function Index. décimale : PER Périodiques Résumé : Autistic children and adults often have sleep disturbances, which may affect their and their family's quality of life. Yet, the relationship between sleep-wake patterns and autism spectrum traits is understudied. Identifying such relationships could lead to future research elucidating common mechanistic underpinnings. Thus, we aimed to determine whether sleep-wake patterns, specifically related to sleep, physical activity, and the daily sleep-wake rhythm (i.e., circadian rhythm), are associated with autism spectrum-related traits. Accelerometer-derived sleep-wake parameters were estimated in individuals with autistic spectrum traits and their family members (N = 267). We evaluated autism spectrum traits using the Social Responsiveness Scale (SRS) to assess the presence and severity of social impairment and the Behavior Rating Inventory of Executive Function (BRIEF) to assess executive function. The linear multivariate regression analysis (using SOLAR-Eclipse) showed that in adults, increased core autism spectrum traits and executive dysfunction were associated with disruption of several sleep-wake parameters, particularly related to the daily sleep-wake rhythm, and that executive dysfunction was associated with disrupted sleep quality and level of physical activity. We highlight the interplay between daytime function and disrupted sleep-wake patterns, specifically related to the daily sleep-wake rhythm, that could guide future research into common mechanisms. LAY SUMMARY: Autistic children and adults often report sleep disturbances. To dissect the relationship between a range of autism spectrum traits and sleep-wake patterns, we assessed social interaction and executive function in participants who also wore actimetry watches on their wrists to assess their sleep-wake patterns. We found that increased impairments in social and executive function occurred with increased sleep-wake disturbances, particularly those related to the circadian rhythm, suggesting that these perturbations/disruptions in the sleep-wake cycle could be connected to autism spectrum traits. En ligne : https://dx.doi.org/10.1002/aur.2660 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473