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Détail de l'auteur
Auteur A. TSOMPANIDIS |
Documents disponibles écrits par cet auteur (2)
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Maternal steroid levels and the autistic traits of the mother and infant / A. TSOMPANIDIS in Molecular Autism, 12 (2021)
[article]
Titre : Maternal steroid levels and the autistic traits of the mother and infant Type de document : Texte imprimé et/ou numérique Auteurs : A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 51 p. Langues : Anglais (eng) Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 51 p.[article] Maternal steroid levels and the autistic traits of the mother and infant [Texte imprimé et/ou numérique] / A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur . - 51 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 51 p.
Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
[article]
Titre : Medical symptoms and conditions in autistic women Type de document : Texte imprimé et/ou numérique Auteurs : T. SIMANTOV, Auteur ; A. POHL, Auteur ; A. TSOMPANIDIS, Auteur ; E. WEIR, Auteur ; M. V. LOMBARDO, Auteur ; A. RUIGROK, Auteur ; P. SMITH, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; F. UZEFOVSKY, Auteur Article en page(s) : p.373-388 Langues : Anglais (eng) Mots-clés : autism clinical females puberty steroids testosterone Index. décimale : PER Périodiques Résumé : Sex-steroids, such as testosterone, are thought to be one of the biological factors implicated in autism. This relies on the sex bias in the diagnosis of autism (boys are approximately four times more likely to be diagnosed than girls) and findings of associations with fetal testosterone levels in traits and abilities related to autism. The current study aimed to examine the association between medical conditions and physical symptoms, which tend to manifest in adulthood, and autism in females. Moreover, we examined their association with autistic traits throughout the spectrum. We focused on autistic women because there is little research focusing on the healthcare needs of autistic women, but those that exist suggest heightened vulnerability, and lower access to medical care. We find that conditions related to steroid hormones function are more frequent in autistic women and that they correlate with autistic traits. Specifically, we found that body mass index, reproductive system diagnoses, prediabetes symptoms, irregular puberty onset, and menstrual irregularities were significantly more frequent in autistic women and were significantly correlated with autistic traits in neurotypical women. The findings have important implications for raising awareness in autistic women of the possibility of medical conditions which might need medical attention. In addition, healthcare providers should consider these associations when performing healthcare maintenance checks and/or screening for autism. En ligne : http://dx.doi.org/10.1177/13623613211022091 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Autism > 26-2 (February 2022) . - p.373-388[article] Medical symptoms and conditions in autistic women [Texte imprimé et/ou numérique] / T. SIMANTOV, Auteur ; A. POHL, Auteur ; A. TSOMPANIDIS, Auteur ; E. WEIR, Auteur ; M. V. LOMBARDO, Auteur ; A. RUIGROK, Auteur ; P. SMITH, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; F. UZEFOVSKY, Auteur . - p.373-388.
Langues : Anglais (eng)
in Autism > 26-2 (February 2022) . - p.373-388
Mots-clés : autism clinical females puberty steroids testosterone Index. décimale : PER Périodiques Résumé : Sex-steroids, such as testosterone, are thought to be one of the biological factors implicated in autism. This relies on the sex bias in the diagnosis of autism (boys are approximately four times more likely to be diagnosed than girls) and findings of associations with fetal testosterone levels in traits and abilities related to autism. The current study aimed to examine the association between medical conditions and physical symptoms, which tend to manifest in adulthood, and autism in females. Moreover, we examined their association with autistic traits throughout the spectrum. We focused on autistic women because there is little research focusing on the healthcare needs of autistic women, but those that exist suggest heightened vulnerability, and lower access to medical care. We find that conditions related to steroid hormones function are more frequent in autistic women and that they correlate with autistic traits. Specifically, we found that body mass index, reproductive system diagnoses, prediabetes symptoms, irregular puberty onset, and menstrual irregularities were significantly more frequent in autistic women and were significantly correlated with autistic traits in neurotypical women. The findings have important implications for raising awareness in autistic women of the possibility of medical conditions which might need medical attention. In addition, healthcare providers should consider these associations when performing healthcare maintenance checks and/or screening for autism. En ligne : http://dx.doi.org/10.1177/13623613211022091 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452