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Auteur Craig NEWSCHAFFER |
Documents disponibles écrits par cet auteur (4)
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Applying a public health approach to autism research: A framework for action / Diana SCHENDEL in Autism Research, 15-4 (April 2022)
[article]
Titre : Applying a public health approach to autism research: A framework for action Type de document : Texte imprimé et/ou numérique Auteurs : Diana SCHENDEL, Auteur ; Anne M. ROUX, Auteur ; Elizabeth MCGHEE HASSRICK, Auteur ; Kristen LYALL, Auteur ; Lindsay SHEA, Auteur ; Giacomo VIVANTI, Auteur ; Andrea WIECKOWSKI TRUBANOVA, Auteur ; Craig NEWSCHAFFER, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.592-601 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Humans Public Health Quality of Life autism spectrum disorder communication knowledge Index. décimale : PER Périodiques Résumé : Most published autism research, and the funding that supports it, remains focused on basic and clinical science. However, the public health impact of autism drives a compelling argument for utilizing a public health approach to autism research. Fundamental to the public health perspective is a focus on health determinants to improve quality of life and to reduce the potential for adverse outcomes across the general population, including in vulnerable subgroups. While the public health research process can be conceptualized as a linear, 3-stage path consisting of discovery - testing - translation/dissemination/implementation, in this paper we propose an integrated, cyclical research framework to advance autism public health objectives in a more comprehensive manner. This involves discovery of primary, secondary and tertiary determinants of health in autism; and use of this evidence base to develop and test detection, intervention, and dissemination strategies and the means to implement them in 'real world' settings. The proposed framework serves to facilitate identification of knowledge gaps, translational barriers, and shortfalls in implementation; guides an iterative research cycle; facilitates purposeful integration of stakeholders and interdisciplinary researchers; and may yield more efficient achievement of improved health and well-being among persons on the autism spectrum at the population-level. LAY SUMMARY: Scientists need better ways to identify and address gaps in autism research, conduct research with stakeholders, and use findings to improve the lives of autistic people. We recommend an approach, based in public health science, to guide research in ways that might impact lives more quickly. En ligne : https://dx.doi.org/10.1002/aur.2689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-4 (April 2022) . - p.592-601[article] Applying a public health approach to autism research: A framework for action [Texte imprimé et/ou numérique] / Diana SCHENDEL, Auteur ; Anne M. ROUX, Auteur ; Elizabeth MCGHEE HASSRICK, Auteur ; Kristen LYALL, Auteur ; Lindsay SHEA, Auteur ; Giacomo VIVANTI, Auteur ; Andrea WIECKOWSKI TRUBANOVA, Auteur ; Craig NEWSCHAFFER, Auteur ; Diana L. ROBINS, Auteur . - p.592-601.
Langues : Anglais (eng)
in Autism Research > 15-4 (April 2022) . - p.592-601
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Humans Public Health Quality of Life autism spectrum disorder communication knowledge Index. décimale : PER Périodiques Résumé : Most published autism research, and the funding that supports it, remains focused on basic and clinical science. However, the public health impact of autism drives a compelling argument for utilizing a public health approach to autism research. Fundamental to the public health perspective is a focus on health determinants to improve quality of life and to reduce the potential for adverse outcomes across the general population, including in vulnerable subgroups. While the public health research process can be conceptualized as a linear, 3-stage path consisting of discovery - testing - translation/dissemination/implementation, in this paper we propose an integrated, cyclical research framework to advance autism public health objectives in a more comprehensive manner. This involves discovery of primary, secondary and tertiary determinants of health in autism; and use of this evidence base to develop and test detection, intervention, and dissemination strategies and the means to implement them in 'real world' settings. The proposed framework serves to facilitate identification of knowledge gaps, translational barriers, and shortfalls in implementation; guides an iterative research cycle; facilitates purposeful integration of stakeholders and interdisciplinary researchers; and may yield more efficient achievement of improved health and well-being among persons on the autism spectrum at the population-level. LAY SUMMARY: Scientists need better ways to identify and address gaps in autism research, conduct research with stakeholders, and use findings to improve the lives of autistic people. We recommend an approach, based in public health science, to guide research in ways that might impact lives more quickly. En ligne : https://dx.doi.org/10.1002/aur.2689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children / Ashley Y. SONG in Autism Research, 15-12 (December 2022)
[article]
Titre : Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children Type de document : Texte imprimé et/ou numérique Auteurs : Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur Article en page(s) : p.2359-2370 Langues : Anglais (eng) Mots-clés : Child Male Pregnancy Female Humans Autism Spectrum Disorder/epidemiology/genetics Prospective Studies Parents Cognition Biological Products Epigenesis, Genetic DNA methylation age acceleration autism spectrum disorder autism-related traits biologic age epigenetic age parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-12 (December 2022) . - p.2359-2370[article] Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children [Texte imprimé et/ou numérique] / Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur . - p.2359-2370.
Langues : Anglais (eng)
in Autism Research > 15-12 (December 2022) . - p.2359-2370
Mots-clés : Child Male Pregnancy Female Humans Autism Spectrum Disorder/epidemiology/genetics Prospective Studies Parents Cognition Biological Products Epigenesis, Genetic DNA methylation age acceleration autism spectrum disorder autism-related traits biologic age epigenetic age parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression / Meghan E. Carey in Journal of Autism and Developmental Disorders, 53-8 (August 2023)
[article]
Titre : Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression Type de document : Texte imprimé et/ou numérique Auteurs : Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2975-2985 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985[article] Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression [Texte imprimé et/ou numérique] / Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.2975-2985.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985
Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 The Periodic Risk Evaluation: A new tool to link Medicaid-enrolled autistic adults to services and support / Lindsay SHEA in Research in Autism Spectrum Disorders, 98 (October 2022)
[article]
Titre : The Periodic Risk Evaluation: A new tool to link Medicaid-enrolled autistic adults to services and support Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay SHEA, Auteur ; Kaitlin H. KOFFER MILLER, Auteur ; Stacy L. NONNEMACHER, Auteur ; Alec BECKER, Auteur ; Pamela TREADWAY, Auteur ; Amy ALFORD, Auteur ; Craig NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur Article en page(s) : 102037 Langues : Anglais (eng) Mots-clés : Autism Medicaid Risk Tool Adult Service use Index. décimale : PER Périodiques Résumé : Background The Periodic Risk Evaluation (PRE) is a new questionnaire-based tool to identify autistic adults enrolled in Medicaid programs who are at risk for adverse outcomes including mental health and medical conditions, law enforcement interaction, stressful life events, substance use, presence of natural supports, and suboptimal living conditions. The PRE is completed by direct service providers and informs case conceptualization to drive changes in needed supports. Method The PRE was tested in a sample of 674 autistic adults with a mean age of 31 years across a large, northeastern state. A random forest model was developed to predict complex case status using the PRE items. Sensitivity, specificity, positive predictive value, and negative predictive value for different PRE score cutoffs were evaluated as the performance measures of interest. Expert clinical assessment, the gold standard for case status, identified 131 individuals (19.4 %) as complex cases in need of modified services and supports. Results The final PRE model identified complex cases in unseen data with 75.5 % accuracy, 71.9 % sensitivity, 76.3 % specificity, 41.8 % positive predictive value, and 92.0 % negative predictive value. Conclusions The PRE may be a useful tool for triaging service needs and delivery to adults on the spectrum. The use of the PRE in the Medicaid system is critical because Medicaid is among the only insurers available during the transition to and throughout adulthood for autistic individuals. Adequate planning and assessment of risk can assist direct support staff in triaging and mitigating risk to minimize adverse outcomes. En ligne : https://doi.org/10.1016/j.rasd.2022.102037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102037[article] The Periodic Risk Evaluation: A new tool to link Medicaid-enrolled autistic adults to services and support [Texte imprimé et/ou numérique] / Lindsay SHEA, Auteur ; Kaitlin H. KOFFER MILLER, Auteur ; Stacy L. NONNEMACHER, Auteur ; Alec BECKER, Auteur ; Pamela TREADWAY, Auteur ; Amy ALFORD, Auteur ; Craig NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur . - 102037.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102037
Mots-clés : Autism Medicaid Risk Tool Adult Service use Index. décimale : PER Périodiques Résumé : Background The Periodic Risk Evaluation (PRE) is a new questionnaire-based tool to identify autistic adults enrolled in Medicaid programs who are at risk for adverse outcomes including mental health and medical conditions, law enforcement interaction, stressful life events, substance use, presence of natural supports, and suboptimal living conditions. The PRE is completed by direct service providers and informs case conceptualization to drive changes in needed supports. Method The PRE was tested in a sample of 674 autistic adults with a mean age of 31 years across a large, northeastern state. A random forest model was developed to predict complex case status using the PRE items. Sensitivity, specificity, positive predictive value, and negative predictive value for different PRE score cutoffs were evaluated as the performance measures of interest. Expert clinical assessment, the gold standard for case status, identified 131 individuals (19.4 %) as complex cases in need of modified services and supports. Results The final PRE model identified complex cases in unseen data with 75.5 % accuracy, 71.9 % sensitivity, 76.3 % specificity, 41.8 % positive predictive value, and 92.0 % negative predictive value. Conclusions The PRE may be a useful tool for triaging service needs and delivery to adults on the spectrum. The use of the PRE in the Medicaid system is critical because Medicaid is among the only insurers available during the transition to and throughout adulthood for autistic individuals. Adequate planning and assessment of risk can assist direct support staff in triaging and mitigating risk to minimize adverse outcomes. En ligne : https://doi.org/10.1016/j.rasd.2022.102037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490