Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Qi JIANG |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Alteration of the fecal microbiota in Chinese children with autism spectrum disorder / Xinyan XIE in Autism Research, 15-6 (June 2022)
[article]
Titre : Alteration of the fecal microbiota in Chinese children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xinyan XIE, Auteur ; Li LI, Auteur ; Xiaoqian WU, Auteur ; Fang HOU, Auteur ; Yanlin CHEN, Auteur ; Liuwei SHI, Auteur ; Qi LIU, Auteur ; Kaiheng ZHU, Auteur ; Qi JIANG, Auteur ; Yanan FENG, Auteur ; Pei XIAO, Auteur ; Jiajia ZHANG, Auteur ; Jianhua GONG, Auteur ; Ranran SONG, Auteur Article en page(s) : p.996-1007 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications Bacteria/genetics Case-Control Studies Child Dysbiosis/complications Feces/microbiology Humans Microbiota Phylogeny Chinese Han population autism spectrum disorder children gut microbiota Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with altered gut microbiota. However, there has been little consensus on the altered bacterial species and studies have had small sample sizes. We aimed to identify the taxonomic composition and evaluate the changes in the fecal microbiota in Chinese children with ASD by using a relatively large sample size. We conducted a case-control study of 101 children with ASD and 103 healthy controls in China. Demographic information and fecal samples were collected, and the V3-V4 hypervariable regions of the bacterial 16S ribosomal RNA (rRNA) gene were sequenced. The alpha and beta diversities between the two groups were significantly different. After correcting for multiple comparisons, at the phylum level the relative abundances of Actinobacteria and Proteobacteria in the case group were significantly higher than those in the control group. The relative abundance of the Escherichia-Shigella genus in the case group was significantly higher than that of the control group, and the relative abundance of Blautia and unclassified_f__Lachnospiraceae in the control group were higher than that of the case group. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States analysis showed that children with ASD may have disturbed functional pathways, such as amino acid metabolism, cofactor and vitamin metabolism, and the AMP-activated protein kinase signaling pathway. This study revealed the characteristics of the intestinal flora of Chinese children with ASD and provided further evidence of gut microbial dysbiosis in ASD. LAY SUMMARY: This study characterized the gut microbiota composition of 101 children with ASD and 103 healthy controls in China. The altered gut microbiota may contribute significantly to the risk of ASD, including significant increases in the relative abundances of Actinobacteria, Proteobacteria and Escherichia-Shigella and significant decrease of Blautia and unclassified_f__Lachnospiraceae. This study provided further evidence of gut microbial dysbiosis in ASD. En ligne : http://dx.doi.org/10.1002/aur.2718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.996-1007[article] Alteration of the fecal microbiota in Chinese children with autism spectrum disorder [Texte imprimé et/ou numérique] / Xinyan XIE, Auteur ; Li LI, Auteur ; Xiaoqian WU, Auteur ; Fang HOU, Auteur ; Yanlin CHEN, Auteur ; Liuwei SHI, Auteur ; Qi LIU, Auteur ; Kaiheng ZHU, Auteur ; Qi JIANG, Auteur ; Yanan FENG, Auteur ; Pei XIAO, Auteur ; Jiajia ZHANG, Auteur ; Jianhua GONG, Auteur ; Ranran SONG, Auteur . - p.996-1007.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.996-1007
Mots-clés : Autism Spectrum Disorder/complications Bacteria/genetics Case-Control Studies Child Dysbiosis/complications Feces/microbiology Humans Microbiota Phylogeny Chinese Han population autism spectrum disorder children gut microbiota Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with altered gut microbiota. However, there has been little consensus on the altered bacterial species and studies have had small sample sizes. We aimed to identify the taxonomic composition and evaluate the changes in the fecal microbiota in Chinese children with ASD by using a relatively large sample size. We conducted a case-control study of 101 children with ASD and 103 healthy controls in China. Demographic information and fecal samples were collected, and the V3-V4 hypervariable regions of the bacterial 16S ribosomal RNA (rRNA) gene were sequenced. The alpha and beta diversities between the two groups were significantly different. After correcting for multiple comparisons, at the phylum level the relative abundances of Actinobacteria and Proteobacteria in the case group were significantly higher than those in the control group. The relative abundance of the Escherichia-Shigella genus in the case group was significantly higher than that of the control group, and the relative abundance of Blautia and unclassified_f__Lachnospiraceae in the control group were higher than that of the case group. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States analysis showed that children with ASD may have disturbed functional pathways, such as amino acid metabolism, cofactor and vitamin metabolism, and the AMP-activated protein kinase signaling pathway. This study revealed the characteristics of the intestinal flora of Chinese children with ASD and provided further evidence of gut microbial dysbiosis in ASD. LAY SUMMARY: This study characterized the gut microbiota composition of 101 children with ASD and 103 healthy controls in China. The altered gut microbiota may contribute significantly to the risk of ASD, including significant increases in the relative abundances of Actinobacteria, Proteobacteria and Escherichia-Shigella and significant decrease of Blautia and unclassified_f__Lachnospiraceae. This study provided further evidence of gut microbial dysbiosis in ASD. En ligne : http://dx.doi.org/10.1002/aur.2718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Interaction between XRN2 mutation and gut microbiota on the risks of autism spectrum disorder / Quan ZHANG ; Yanlin CHEN ; Fang HOU ; Kaiheng ZHU ; Qi JIANG ; Pei XIAO ; Zhen XIANG ; Xvfang WU ; Yixi FAN ; Xinyan XIE ; Li LI ; Ranran SONG in Research in Autism Spectrum Disorders, 110 (February 2024)
[article]
Titre : Interaction between XRN2 mutation and gut microbiota on the risks of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Quan ZHANG, Auteur ; Yanlin CHEN, Auteur ; Fang HOU, Auteur ; Kaiheng ZHU, Auteur ; Qi JIANG, Auteur ; Pei XIAO, Auteur ; Zhen XIANG, Auteur ; Xvfang WU, Auteur ; Yixi FAN, Auteur ; Xinyan XIE, Auteur ; Li LI, Auteur ; Ranran SONG, Auteur Article en page(s) : p.102297 Mots-clés : Autism spectrum disorder Gut microbiota School children Genetic variant Index. décimale : PER Périodiques Résumé : Background The intestinal dysbiosis can be observed in patients with autism spectrum disorder (ASD), partly explained by the alteration in gut microbiota composition. Our study aims to screen ASD causal variants and explore the potential interaction between variants and gut microbiota. Methods We conducted the expression quantitative trait loci (eQTL) analysis to identify variations that regulated the expression of the ASD risk gene XRN2, and then validated genetic susceptibility to ASD risk in the case-control study among 627 ASD children and 606 healthy controls. The fecal samples were analyzed by 16S rRNA sequencing. Logistic regression model analysis was conducted to examine the interaction. Results We identified that rs2295412 was a cis-eQTL of XRN2 in brain tissues (P < 0.0005), And individuals with rs2295412 TC genotypes had decreased ASD risks compared to the TT genotype (OR = 0.42, 95% CI: 0.19?0.94, P = 0.036). And rs2295412 genotypes and the abundance of f__Monoglobaceae showed the interaction on the ASD risks (Pmul = 0.049). Compared to the children with a higher abundance of f__Monoglobaceae and rs2295412 CT+CC genotype, the children with a lower abundance and TT genotype might have higher ASD risks. Conclusions These findings suggested the potential interaction between genetic variation and gut microbiota on ASD risks, which enhanced the understanding of pathogenic mechanisms and the underlying etiology of ASD, and provided clues for future investigations. En ligne : https://doi.org/10.1016/j.rasd.2023.102297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102297[article] Interaction between XRN2 mutation and gut microbiota on the risks of autism spectrum disorder [Texte imprimé et/ou numérique] / Quan ZHANG, Auteur ; Yanlin CHEN, Auteur ; Fang HOU, Auteur ; Kaiheng ZHU, Auteur ; Qi JIANG, Auteur ; Pei XIAO, Auteur ; Zhen XIANG, Auteur ; Xvfang WU, Auteur ; Yixi FAN, Auteur ; Xinyan XIE, Auteur ; Li LI, Auteur ; Ranran SONG, Auteur . - p.102297.
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102297
Mots-clés : Autism spectrum disorder Gut microbiota School children Genetic variant Index. décimale : PER Périodiques Résumé : Background The intestinal dysbiosis can be observed in patients with autism spectrum disorder (ASD), partly explained by the alteration in gut microbiota composition. Our study aims to screen ASD causal variants and explore the potential interaction between variants and gut microbiota. Methods We conducted the expression quantitative trait loci (eQTL) analysis to identify variations that regulated the expression of the ASD risk gene XRN2, and then validated genetic susceptibility to ASD risk in the case-control study among 627 ASD children and 606 healthy controls. The fecal samples were analyzed by 16S rRNA sequencing. Logistic regression model analysis was conducted to examine the interaction. Results We identified that rs2295412 was a cis-eQTL of XRN2 in brain tissues (P < 0.0005), And individuals with rs2295412 TC genotypes had decreased ASD risks compared to the TT genotype (OR = 0.42, 95% CI: 0.19?0.94, P = 0.036). And rs2295412 genotypes and the abundance of f__Monoglobaceae showed the interaction on the ASD risks (Pmul = 0.049). Compared to the children with a higher abundance of f__Monoglobaceae and rs2295412 CT+CC genotype, the children with a lower abundance and TT genotype might have higher ASD risks. Conclusions These findings suggested the potential interaction between genetic variation and gut microbiota on ASD risks, which enhanced the understanding of pathogenic mechanisms and the underlying etiology of ASD, and provided clues for future investigations. En ligne : https://doi.org/10.1016/j.rasd.2023.102297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520