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Auteur Pablo JUAREZ |
Documents disponibles écrits par cet auteur (2)
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Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors / Brett D DUFOUR in Autism, 27-6 (August 2023)
[article]
Titre : Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Brett D DUFOUR, Auteur ; Erin MCBRIDE, Auteur ; Trevor BARTLEY, Auteur ; Pablo JUAREZ, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur Article en page(s) : p.1730-1745 Langues : Anglais (eng) Mots-clés : autism;behavior;human;interneuron;postmortem Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. How specific anatomical alterations contribute to the clinical profile of autism spectrum disorder remains largely uncharacterized. We have previously shown that parvalbumin-positive Chandelier cells, a specific type of GABAergic interneuron, are reduced in number in the autism spectrum disorder prefrontal cortex. Here, we assessed the relationship between interneuron pathology with autism spectrum disorder symptom severity and comorbidity. We collected clinical records from autism (n=20) and control (n=19) brain donors, from whom we previously characterized GABAergic interneuron pathology in three regions of the prefrontal cortex (BA9, 46, and 47). We assessed the relationship between the severity of core symptoms, as indicated by Autism Diagnostic Interview-Revised scores, and Chandelier cell pathology in autism spectrum disorder, and also differences in interneuron pathology associated with autism spectrum disorder comorbidities. Total GABAergic interneuron number was significantly reduced in autism spectrum disorder cases with intellectual disability in the prefrontal cortex (PFC )-by 36.6% relative to autism spectrum disorder without intellectual disability and by 38.7% relative to neurotypical controls. The severity of autism spectrum disorder motor stereotypies was correlated with the severity of Chandelier cell loss in BA47, as indicated by reductions in parvalbumin+ interneurons and GABA transporter 1+ cartridges. Chandelier cell loss is associated with the core autism spectrum disorder symptom domain of restricted repetitive behaviors and likely plays a role in stereotypic motor mannerisms. Intellectual impairment in autism spectrum disorder reflects a more severe form of a common underlying neuropathology-cortical GABAergic interneuron loss.Lay AbstractAutism spectrum disorder is a neurodevelopmental condition characterized by deficits in sociability and communication and the presence of repetitive behaviors. How specific pathological alterations of the brain contribute to the clinical profile of autism spectrum disorder remains unknown. We previously found that a specific type of inhibitory interneuron is reduced in number in the autism spectrum disorder prefrontal cortex. Here, we assessed the relationship between interneuron reduction and autism spectrum disorder symptom severity. We collected clinical records from autism spectrum disorder (n=20) and assessed the relationship between the severity of symptoms and interneuron number. We found that the reduced number of inhibitory interneurons that we previously reported is linked to specific symptoms of autism spectrum disorder, particularly stereotypic movements and intellectual impairments. En ligne : http://dx.doi.org/10.1177/13623613231154053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509
in Autism > 27-6 (August 2023) . - p.1730-1745[article] Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors [Texte imprimé et/ou numérique] / Brett D DUFOUR, Auteur ; Erin MCBRIDE, Auteur ; Trevor BARTLEY, Auteur ; Pablo JUAREZ, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur . - p.1730-1745.
Langues : Anglais (eng)
in Autism > 27-6 (August 2023) . - p.1730-1745
Mots-clés : autism;behavior;human;interneuron;postmortem Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. How specific anatomical alterations contribute to the clinical profile of autism spectrum disorder remains largely uncharacterized. We have previously shown that parvalbumin-positive Chandelier cells, a specific type of GABAergic interneuron, are reduced in number in the autism spectrum disorder prefrontal cortex. Here, we assessed the relationship between interneuron pathology with autism spectrum disorder symptom severity and comorbidity. We collected clinical records from autism (n=20) and control (n=19) brain donors, from whom we previously characterized GABAergic interneuron pathology in three regions of the prefrontal cortex (BA9, 46, and 47). We assessed the relationship between the severity of core symptoms, as indicated by Autism Diagnostic Interview-Revised scores, and Chandelier cell pathology in autism spectrum disorder, and also differences in interneuron pathology associated with autism spectrum disorder comorbidities. Total GABAergic interneuron number was significantly reduced in autism spectrum disorder cases with intellectual disability in the prefrontal cortex (PFC )-by 36.6% relative to autism spectrum disorder without intellectual disability and by 38.7% relative to neurotypical controls. The severity of autism spectrum disorder motor stereotypies was correlated with the severity of Chandelier cell loss in BA47, as indicated by reductions in parvalbumin+ interneurons and GABA transporter 1+ cartridges. Chandelier cell loss is associated with the core autism spectrum disorder symptom domain of restricted repetitive behaviors and likely plays a role in stereotypic motor mannerisms. Intellectual impairment in autism spectrum disorder reflects a more severe form of a common underlying neuropathology-cortical GABAergic interneuron loss.Lay AbstractAutism spectrum disorder is a neurodevelopmental condition characterized by deficits in sociability and communication and the presence of repetitive behaviors. How specific pathological alterations of the brain contribute to the clinical profile of autism spectrum disorder remains unknown. We previously found that a specific type of inhibitory interneuron is reduced in number in the autism spectrum disorder prefrontal cortex. Here, we assessed the relationship between interneuron reduction and autism spectrum disorder symptom severity. We collected clinical records from autism spectrum disorder (n=20) and assessed the relationship between the severity of symptoms and interneuron number. We found that the reduced number of inhibitory interneurons that we previously reported is linked to specific symptoms of autism spectrum disorder, particularly stereotypic movements and intellectual impairments. En ligne : http://dx.doi.org/10.1177/13623613231154053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 Opportunities and Challenges in Developing Technology-Based Social Skills Interventions for Adolescents with Autism Spectrum Disorder: A Qualitative Analysis of Parent Perspectives / Roxanne N. RASHEDI in Journal of Autism and Developmental Disorders, 52-10 (October 2022)
[article]
Titre : Opportunities and Challenges in Developing Technology-Based Social Skills Interventions for Adolescents with Autism Spectrum Disorder: A Qualitative Analysis of Parent Perspectives Type de document : Texte imprimé et/ou numérique Auteurs : Roxanne N. RASHEDI, Auteur ; Kemberlee BONNET, Auteur ; Rebecca J. SCHULTE, Auteur ; David G. SCHLUNDT, Auteur ; Amy R. SWANSON, Auteur ; Amy KINSMAN, Auteur ; Nicole BARDETT, Auteur ; Pablo JUAREZ, Auteur ; Zachary WARREN, Auteur ; Gautam BISWAS, Auteur ; Maithilee KUNDA, Auteur Article en page(s) : p.4321-4336 Langues : Anglais (eng) Mots-clés : Autism Qualitative Technology Index. décimale : PER Périodiques Résumé : Interest continues to be high in technology-based interventions for individuals with autism spectrum disorder (ASD). Understanding the preferences and challenges of technology use among individuals with ASD can inform the design of such interventions. Through 18 interviews with parents, we used an iterative inductive-deductive approach to qualitative analysis and explored uses of technology for social skills development among adolescents with ASD. Our findings include parents' observations about their adolescent's preferences in types of technology devices and digital content, as well as both positive and negative effects of technology use on mood and behavior. Parents highlighted several avenues of technological preferences and risks that may inform intervention design, enhance user engagement, and capitalize on users' strengths while buttressing areas for growth. En ligne : http://dx.doi.org/10.1007/s10803-021-05315-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4321-4336[article] Opportunities and Challenges in Developing Technology-Based Social Skills Interventions for Adolescents with Autism Spectrum Disorder: A Qualitative Analysis of Parent Perspectives [Texte imprimé et/ou numérique] / Roxanne N. RASHEDI, Auteur ; Kemberlee BONNET, Auteur ; Rebecca J. SCHULTE, Auteur ; David G. SCHLUNDT, Auteur ; Amy R. SWANSON, Auteur ; Amy KINSMAN, Auteur ; Nicole BARDETT, Auteur ; Pablo JUAREZ, Auteur ; Zachary WARREN, Auteur ; Gautam BISWAS, Auteur ; Maithilee KUNDA, Auteur . - p.4321-4336.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4321-4336
Mots-clés : Autism Qualitative Technology Index. décimale : PER Périodiques Résumé : Interest continues to be high in technology-based interventions for individuals with autism spectrum disorder (ASD). Understanding the preferences and challenges of technology use among individuals with ASD can inform the design of such interventions. Through 18 interviews with parents, we used an iterative inductive-deductive approach to qualitative analysis and explored uses of technology for social skills development among adolescents with ASD. Our findings include parents' observations about their adolescent's preferences in types of technology devices and digital content, as well as both positive and negative effects of technology use on mood and behavior. Parents highlighted several avenues of technological preferences and risks that may inform intervention design, enhance user engagement, and capitalize on users' strengths while buttressing areas for growth. En ligne : http://dx.doi.org/10.1007/s10803-021-05315-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486