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Détail de l'auteur
Auteur Juhi PANDEY |
Documents disponibles écrits par cet auteur (16)
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The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism / Kristen LYALL in Autism Research, 13-6 (June 2020)
[article]
Titre : The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur Article en page(s) : p.998-1010 Langues : Anglais (eng) Mots-clés : autism autism-related traits high familial risk parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age?30?years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30?years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted ? = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted ? associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Autism Research > 13-6 (June 2020) . - p.998-1010[article] The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur . - p.998-1010.
Langues : Anglais (eng)
in Autism Research > 13-6 (June 2020) . - p.998-1010
Mots-clés : autism autism-related traits high familial risk parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age?30?years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30?years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted ? = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted ? associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders / Jamie KLEINMAN in Journal of Autism and Developmental Disorders, 38-5 (May 2008)
[article]
Titre : The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jamie KLEINMAN, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Hilary BOORSTEIN, Auteur ; Pamela VENTOLA, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Saasha SUTERA, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur Année de publication : 2008 Article en page(s) : p.827-839 Langues : Anglais (eng) Mots-clés : Autism Early-identification Pediatric-screening Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16–30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42–54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0450-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416
in Journal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.827-839[article] The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jamie KLEINMAN, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Hilary BOORSTEIN, Auteur ; Pamela VENTOLA, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Saasha SUTERA, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur . - 2008 . - p.827-839.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.827-839
Mots-clés : Autism Early-identification Pediatric-screening Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16–30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42–54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0450-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416