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Auteur Ann WAGNER |
Documents disponibles écrits par cet auteur (4)
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Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 42-3 (March 2012)
[article]
Titre : Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur Année de publication : 2012 Article en page(s) : p.460-467 Langues : Anglais (eng) Mots-clés : Autism Asperger syndrome Life history Neuropathology Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467[article] Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; James T. MCCRACKEN, Auteur ; Karen E. BEARSS, Auteur ; Fay ROBINSON, Auteur ; Eric HOLLANDER, Auteur ; Bryan H. KING, Auteur ; Joel D. BREGMAN, Auteur ; Lin SIKICH, Auteur ; Kimberly DUKES, Auteur ; Lisa SULLIVAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Young-Shin KIM, Auteur ; Louise RITZ, Auteur ; Deborah HIRTZ, Auteur ; Ann WAGNER, Auteur . - 2012 . - p.460-467.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.460-467
Mots-clés : Autism Asperger syndrome Life history Neuropathology Adult Index. décimale : PER Périodiques Résumé : Despite recent interest in the pathogenesis of the autism spectrum disorders (pervasive developmental disorders), neuropathological descriptions of brains of individuals with well documented clinical information and without potentially confounding symptomatology are exceptionally rare. Asperger syndrome differs from classic autism by lack of cognitive impairment or delay in expressive language acquisition. We examined the 1,570 g brain of a 63 year old otherwise healthy mathematician with an Autistic Spectrum Disorder of Asperger subtype. Except for an atypical gyral pattern and megalencephaly, we detected no specific neuropathologic abnormality. Taken together, the behavioral data and pathological findings in this case are compatible with an early neurodevelopmental process affecting multiple neuroanatomic networks, but without a convincing morphologic signature detectable with routine neuropathologic technology. En ligne : http://dx.doi.org/10.1007/s10803-011-1259-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 Designing Research Studies on Psychosocial Interventions in Autism / Tristram SMITH in Journal of Autism and Developmental Disorders, 37-2 (February 2007)
[article]
Titre : Designing Research Studies on Psychosocial Interventions in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Tristram SMITH, Auteur ; Catherine LORD, Auteur ; Geraldine DAWSON, Auteur ; Lawrence SCAHILL, Auteur ; Donald GUTHRIE, Auteur ; Samuel L ODOM, Auteur ; Ann WAGNER, Auteur ; Sally J ROGERS, Auteur Année de publication : 2007 Article en page(s) : p.354-366 Langues : Anglais (eng) Mots-clés : Autism Psychosocial-intervention Behavioral-treatment Clinical-trial Single-subject-design Index. décimale : PER Périodiques Résumé : To address methodological challenges in research on psychosocial interventions for autism spectrum disorder (ASD), a model was developed for systematically validating and disseminating interventions in a sequence of steps. First, initial efficacy studies are conducted to establish interventions as promising. Next, promising interventions are assembled into a manual, which undergoes pilot-testing. Then, randomized clinical trials test efficacy under controlled conditions. Finally, effectiveness studies evaluate outcomes in community settings. Guidelines for research designs at each step are presented. Based on the model, current priorities in ASD research include (a) preparation for efficacy and effectiveness trials by developing manuals for interventions that have shown promise and (b) initial efficacy studies on interventions for core features of ASD such as social reciprocity. En ligne : http://dx.doi.org/10.1007/s10803-006-0173-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640
in Journal of Autism and Developmental Disorders > 37-2 (February 2007) . - p.354-366[article] Designing Research Studies on Psychosocial Interventions in Autism [Texte imprimé et/ou numérique] / Tristram SMITH, Auteur ; Catherine LORD, Auteur ; Geraldine DAWSON, Auteur ; Lawrence SCAHILL, Auteur ; Donald GUTHRIE, Auteur ; Samuel L ODOM, Auteur ; Ann WAGNER, Auteur ; Sally J ROGERS, Auteur . - 2007 . - p.354-366.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-2 (February 2007) . - p.354-366
Mots-clés : Autism Psychosocial-intervention Behavioral-treatment Clinical-trial Single-subject-design Index. décimale : PER Périodiques Résumé : To address methodological challenges in research on psychosocial interventions for autism spectrum disorder (ASD), a model was developed for systematically validating and disseminating interventions in a sequence of steps. First, initial efficacy studies are conducted to establish interventions as promising. Next, promising interventions are assembled into a manual, which undergoes pilot-testing. Then, randomized clinical trials test efficacy under controlled conditions. Finally, effectiveness studies evaluate outcomes in community settings. Guidelines for research designs at each step are presented. Based on the model, current priorities in ASD research include (a) preparation for efficacy and effectiveness trials by developing manuals for interventions that have shown promise and (b) initial efficacy studies on interventions for core features of ASD such as social reciprocity. En ligne : http://dx.doi.org/10.1007/s10803-006-0173-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640 Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms / Audrey THURM in Autism Research, 11-2 (February 2018)
[article]
Titre : Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms Type de document : Texte imprimé et/ou numérique Auteurs : Audrey THURM, Auteur ; Elizabeth M. POWELL, Auteur ; Jeffrey L. NEUL, Auteur ; Ann WAGNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur Année de publication : 2018 Article en page(s) : p.212-222 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such “regression” have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field with respect to clinical studies, describing gaps in knowledge based on limited methods and prospective data collected. Biological mechanisms that have been shown to account for regression early in development in specific conditions are discussed, as well as potential mechanisms that have not yet been explored. Suggestions include use of model systems during the developmental period and cutting?edge methods, including non?invasive imaging that may afford opportunities for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. Autism Res 2018, 11: 212–222. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Loss of previously acquired skills, or regression, has been reported in Autism Spectrum Disorder since Kanner's reports in the 1950's. The current report reflects discussion from an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field regarding clinical studies and suggests use of model systems during the developmental period and cutting?edge methods, for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. En ligne : https://doi.org/10.1002/aur.1903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-2 (February 2018) . - p.212-222[article] Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms [Texte imprimé et/ou numérique] / Audrey THURM, Auteur ; Elizabeth M. POWELL, Auteur ; Jeffrey L. NEUL, Auteur ; Ann WAGNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - 2018 . - p.212-222.
Langues : Anglais (eng)
in Autism Research > 11-2 (February 2018) . - p.212-222
Index. décimale : PER Périodiques Résumé : Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such “regression” have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field with respect to clinical studies, describing gaps in knowledge based on limited methods and prospective data collected. Biological mechanisms that have been shown to account for regression early in development in specific conditions are discussed, as well as potential mechanisms that have not yet been explored. Suggestions include use of model systems during the developmental period and cutting?edge methods, including non?invasive imaging that may afford opportunities for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. Autism Res 2018, 11: 212–222. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Loss of previously acquired skills, or regression, has been reported in Autism Spectrum Disorder since Kanner's reports in the 1950's. The current report reflects discussion from an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field regarding clinical studies and suggests use of model systems during the developmental period and cutting?edge methods, for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. En ligne : https://doi.org/10.1002/aur.1903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 39-5 (May 2009)
[article]
Titre : Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.720-729 Langues : Anglais (eng) Mots-clés : Autism Clinical-trial-methodology Risperidone Behavior-therapy Index. décimale : PER Périodiques Résumé : This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-008-0675-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729[article] Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.720-729.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729
Mots-clés : Autism Clinical-trial-methodology Risperidone Behavior-therapy Index. décimale : PER Périodiques Résumé : This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-008-0675-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732