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Auteur Jocelyne BACHEVALIER |
Documents disponibles écrits par cet auteur (3)
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Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study / Chris GUNTER in Autism Research, 15-3 (March 2022)
[article]
Titre : Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study Type de document : Texte imprimé et/ou numérique Auteurs : Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur Article en page(s) : p.447-463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-3 (March 2022) . - p.447-463[article] Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study [Texte imprimé et/ou numérique] / Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur . - p.447-463.
Langues : Anglais (eng)
in Autism Research > 15-3 (March 2022) . - p.447-463
Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 Temporal lobe structures and memory in nonhuman primates: implications for autism / Jocelyne BACHEVALIER
Titre : Temporal lobe structures and memory in nonhuman primates: implications for autism Type de document : Texte imprimé et/ou numérique Auteurs : Jocelyne BACHEVALIER, Auteur Année de publication : 2008 Importance : p.23-42 Langues : Anglais (eng) Index. décimale : SCI-F SCI-F - Psychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=674 Temporal lobe structures and memory in nonhuman primates: implications for autism [Texte imprimé et/ou numérique] / Jocelyne BACHEVALIER, Auteur . - 2008 . - p.23-42.
Langues : Anglais (eng)
Index. décimale : SCI-F SCI-F - Psychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=674 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire The orbitofrontal-amygdala system in nonhuman primates : function, development, and early insult / Jocelyne BACHEVALIER
Titre : The orbitofrontal-amygdala system in nonhuman primates : function, development, and early insult Type de document : Texte imprimé et/ou numérique Auteurs : Jocelyne BACHEVALIER, Auteur Année de publication : 2006 Importance : p.177-189 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792 The orbitofrontal-amygdala system in nonhuman primates : function, development, and early insult [Texte imprimé et/ou numérique] / Jocelyne BACHEVALIER, Auteur . - 2006 . - p.177-189.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire