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Daily Health Symptoms of Mothers of Adolescents and Adults with Fragile X Syndrome and Mothers of Adolescents and Adults with Autism Spectrum Disorder / Leann E. SMITH in Journal of Autism and Developmental Disorders, 42-9 (September 2012)
[article]
Titre : Daily Health Symptoms of Mothers of Adolescents and Adults with Fragile X Syndrome and Mothers of Adolescents and Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leann E. SMITH, Auteur ; Marsha MAILICK SELTZER, Auteur ; Jan S. GREENBERG, Auteur Année de publication : 2012 Article en page(s) : p.1836-1846 Langues : Anglais (eng) Mots-clés : Fragile X premutation Autism spectrum disorders Health symptoms Index. décimale : PER Périodiques Résumé : Health symptoms of mothers of adolescents and adults with fragile X syndrome (FXS; n = 112) were compared to a nationally-representative sample of mothers of similarly-aged children without disabilities (n = 230) as well as to a sample of mothers of adolescents and adults with autism spectrum disorders (ASD; n = 96). Health symptoms experienced in the previous 24 h were recorded during 8 consecutive days of a daily diary study. Both mothers of a son or daughter with FXS and mothers of a son or daughter with ASD had a higher proportion of days with headaches, backaches, muscle soreness, fatigue, and hot flashes than mothers of children without disabilities. Mothers of children with disabilities appear to be at particular risk for health problems, highlighting a need for comprehensive services for families across the lifespan. En ligne : http://dx.doi.org/10.1007/s10803-011-1422-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180
in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1836-1846[article] Daily Health Symptoms of Mothers of Adolescents and Adults with Fragile X Syndrome and Mothers of Adolescents and Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Leann E. SMITH, Auteur ; Marsha MAILICK SELTZER, Auteur ; Jan S. GREENBERG, Auteur . - 2012 . - p.1836-1846.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1836-1846
Mots-clés : Fragile X premutation Autism spectrum disorders Health symptoms Index. décimale : PER Périodiques Résumé : Health symptoms of mothers of adolescents and adults with fragile X syndrome (FXS; n = 112) were compared to a nationally-representative sample of mothers of similarly-aged children without disabilities (n = 230) as well as to a sample of mothers of adolescents and adults with autism spectrum disorders (ASD; n = 96). Health symptoms experienced in the previous 24 h were recorded during 8 consecutive days of a daily diary study. Both mothers of a son or daughter with FXS and mothers of a son or daughter with ASD had a higher proportion of days with headaches, backaches, muscle soreness, fatigue, and hot flashes than mothers of children without disabilities. Mothers of children with disabilities appear to be at particular risk for health problems, highlighting a need for comprehensive services for families across the lifespan. En ligne : http://dx.doi.org/10.1007/s10803-011-1422-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 The Autisms / Craig M. POWELL
Titre : The Autisms : Molecules to Model Systems Type de document : Texte imprimé et/ou numérique Auteurs : Craig M. POWELL, Directeur de publication ; Lisa M. MONTEGGIA, Directeur de publication Editeur : Oxford [Angleterre] : Oxford University Press Année de publication : 2013 Importance : 403 p. Présentation : ill. Format : 18,5cm x 26cm x 2,8cm ISBN/ISSN/EAN : 978-0-19-974431-2 Note générale : Bibliogr., Index Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease.
These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 The Autisms : Molecules to Model Systems [Texte imprimé et/ou numérique] / Craig M. POWELL, Directeur de publication ; Lisa M. MONTEGGIA, Directeur de publication . - Oxford [Angleterre] : Oxford University Press, 2013 . - 403 p. : ill. ; 18,5cm x 26cm x 2,8cm.
ISBN : 978-0-19-974431-2
Bibliogr., Index
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease.
These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Contenu
- Introduction / Craig M. POWELL
- Autism and Autism Spectrum Disorders: Clinical Overview / Lisa JOSEPH
- Neuroimaging in Autism Spectrum Disorders Human Imaging / Mikle SOUTH
- An overview of the genetics of autism spectrum disorders / Joseph D. BUXBAUM
- Rett syndrome: On Clinical and Genetic Features, and Experimental Models based on Mecp2 dysfunction / Gaston CALFA
- Mecp2 Knockout in mouse models of Rett syndrome / Megumi ADACHI
- Putting into perspective the use of the Fmr1 KO mouse as a model for autism spectrum disorder / Richard PAYLOR
- Molecular functions of the mammalian fragile X mental retardation protein: Insights into mental retardation and synaptic plasticity / Claudia BAGNI
- Tuberous Sclerosis and Autism / Dan EHNINGER
- PTEN and autism with macrocephaly / Craig M. POWELL
- SHANK gene family and autism / Craig M. POWELL
- Smith-Lemli-Opitz Syndrome and Role of Cholesterol in Autism / Geeta SARPHARE
- Angelman Syndrome / Edwin J. WEEBER
- Neuroligins and neurexins: Bridging the synaptic cleft in autism / Craig M. POWELL
- Alterations of the serotonin-melatonin pathway in autism spectrum disorders: Biological evidence and clinical consequences / Cecile PAGAN
- CNTNAP2 and autism spectrum disorders / Olga PENAGARIKANO
- Chromosome 15q11.2q13.3 Aneusomies and Autism Spectrum Disorders / David J. WU
- Oxytocin and vasopressin: Mechanisms for potential sex differences observed in ASD / C. Sue CARTER
- FOXP2: Linking language and autism / Genevieve KONOPKA
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0002323 SCI-D POW Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible Understanding Fragile X Syndrome: A Guide for Families and Professionals / Isabel FERNANDEZ CARVAJAL in Good Autism Practice - GAP, 13-1 (May 2012)
[article]
Titre : Understanding Fragile X Syndrome: A Guide for Families and Professionals Type de document : Texte imprimé et/ou numérique Auteurs : Isabel FERNANDEZ CARVAJAL, Auteur ; David ALDRIDGE, Auteur Année de publication : 2012 Article en page(s) : p.84 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Good Autism Practice - GAP > 13-1 (May 2012) . - p.84[article] Understanding Fragile X Syndrome: A Guide for Families and Professionals [Texte imprimé et/ou numérique] / Isabel FERNANDEZ CARVAJAL, Auteur ; David ALDRIDGE, Auteur . - 2012 . - p.84.
Langues : Anglais (eng)
in Good Autism Practice - GAP > 13-1 (May 2012) . - p.84
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 Visual Attention and Autistic Behavior in Infants with Fragile X Syndrome / Jane E. ROBERTS in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
[article]
Titre : Visual Attention and Autistic Behavior in Infants with Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. ROBERTS, Auteur ; Deborah D. HATTON, Auteur ; Anna C. LONG, Auteur ; Vittoria ANELLO, Auteur ; John COLOMBO, Auteur Année de publication : 2012 Article en page(s) : p.937-946 Langues : Anglais (eng) Mots-clés : Fragile X Autism Early detection Heart rate Visual attention High-risk infants Index. décimale : PER Périodiques Résumé : Aberrant attention is a core feature of fragile X syndrome (FXS), however, little is known regarding the developmental trajectory and underlying physiological processes of attention deficits in FXS. Atypical visual attention is an early emerging and robust indictor of autism in idiopathic (non-FXS) autism. Using a biobehavioral approach with gaze direction and heart activity, we examined visual attention in infants with FXS at 9, 12, and 18 months of age with a cross-sectional comparison to 12-month-old typically developing infants. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS compared to typical controls. Look duration and increased latency to disengage attention were correlated with severity of autistic behavior but not mental age. En ligne : http://dx.doi.org/10.1007/s10803-011-1316-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.937-946[article] Visual Attention and Autistic Behavior in Infants with Fragile X Syndrome [Texte imprimé et/ou numérique] / Jane E. ROBERTS, Auteur ; Deborah D. HATTON, Auteur ; Anna C. LONG, Auteur ; Vittoria ANELLO, Auteur ; John COLOMBO, Auteur . - 2012 . - p.937-946.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.937-946
Mots-clés : Fragile X Autism Early detection Heart rate Visual attention High-risk infants Index. décimale : PER Périodiques Résumé : Aberrant attention is a core feature of fragile X syndrome (FXS), however, little is known regarding the developmental trajectory and underlying physiological processes of attention deficits in FXS. Atypical visual attention is an early emerging and robust indictor of autism in idiopathic (non-FXS) autism. Using a biobehavioral approach with gaze direction and heart activity, we examined visual attention in infants with FXS at 9, 12, and 18 months of age with a cross-sectional comparison to 12-month-old typically developing infants. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS compared to typical controls. Look duration and increased latency to disengage attention were correlated with severity of autistic behavior but not mental age. En ligne : http://dx.doi.org/10.1007/s10803-011-1316-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156