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2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam / S. H. F. LEE in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
[article]
Titre : 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam Type de document : Texte imprimé et/ou numérique Auteurs : S. H. F. LEE, Auteur ; S. A. AZIZ, Auteur ; M. HAMID, Auteur ; Y. C. LIM, Auteur ; D. KOH, Auteur ; L. L. CHAW, Auteur Article en page(s) : p.4577-4586 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Brunei Case-Control Studies Child Child, Preschool Female Fingers Hand Humans Male Sex Characteristics 2D:4D ratio 2D:4D ratio symmetry Androgens Autism spectrum disorders (ASD) Brunei Darussalam Digit ratio Extreme male brain (EMB) Hormones Testosterone this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR)?=?0.57 (95% Confidence Interval (CI): 0.31-0.96); p?=?0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR?=?3.09 (95% CI: 0.98-19.86); p?=?0.144] or the median right hand 2D:4D ratio [OR?=?1.23 (95% CI: 0.42-3.88); p?=?0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r)?=?0.48; 95% CI: 0.076-0.75, p?=?0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586[article] 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam [Texte imprimé et/ou numérique] / S. H. F. LEE, Auteur ; S. A. AZIZ, Auteur ; M. HAMID, Auteur ; Y. C. LIM, Auteur ; D. KOH, Auteur ; L. L. CHAW, Auteur . - p.4577-4586.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586
Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Brunei Case-Control Studies Child Child, Preschool Female Fingers Hand Humans Male Sex Characteristics 2D:4D ratio 2D:4D ratio symmetry Androgens Autism spectrum disorders (ASD) Brunei Darussalam Digit ratio Extreme male brain (EMB) Hormones Testosterone this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR)?=?0.57 (95% Confidence Interval (CI): 0.31-0.96); p?=?0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR?=?3.09 (95% CI: 0.98-19.86); p?=?0.144] or the median right hand 2D:4D ratio [OR?=?1.23 (95% CI: 0.42-3.88); p?=?0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r)?=?0.48; 95% CI: 0.076-0.75, p?=?0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / L. MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)
[article]
Titre : 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study Type de document : Texte imprimé et/ou numérique Auteurs : L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3244-3252 Langues : Anglais (eng) Mots-clés : 2D:4D ratio Adhd Autism Hormones Neurodevelopmental disorders Sex Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252[article] 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study [Texte imprimé et/ou numérique] / L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur . - p.3244-3252.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252
Mots-clés : 2D:4D ratio Adhd Autism Hormones Neurodevelopmental disorders Sex Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368