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Faire une suggestionA contrast of comorbid condition and adaptive function between children with Autism Spectrum Disorder from clinical and non-clinical populations / Ju Hee PARK in Research in Autism Spectrum Disorders, 8-11 (November 2014)
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Titre : A contrast of comorbid condition and adaptive function between children with Autism Spectrum Disorder from clinical and non-clinical populations Type de document : texte imprimé Auteurs : Ju Hee PARK, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Jungeun SONG, Auteur ; Bennett L. LEVENTHAL, Auteur Article en page(s) : p.1471-1481 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorders Comorbid condition Adaptive function BASC-2-PRS Index. décimale : PER Périodiques Résumé : To investigate factors that might hamper early identification of Autism Spectrum Disorder (ASD), the present study examined differences between comorbid conditions and adaptive functions measured by the BASC-2 PRS in an epidemiologically ascertained group of children with ASD (Clinical and Non-clinical ASD groups), those who were screened positive but confirmed not to have ASD (No-ASD), and a group of typical, community children (N = 5222). Results indicate that the Clinical ASD group scored lower on the Externalizing Problems composite, Aggression, and Conduct Problems scales than did the No-ASD group whereas the Non-clinical ASD group did not differ from the other two groups except on the Conduct Problem scale. Further, the Clinical ASD group significantly scored lower than the other two groups the Adaptive Skills composite. The scores of the Clinical ASD group on the Social Skills and Leadership scales were lower than those in the No-ASD group, but not those in the Non-clinical ASD group. Results suggest that the frequent comorbid behavioral problems and higher adaptive skills of children in a non-clinical population, compared to a clinical population could mask their core ASD symptoms, resulting in a delay for caretakers to seek appropriate services for these children. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1471-1481[article] A contrast of comorbid condition and adaptive function between children with Autism Spectrum Disorder from clinical and non-clinical populations [texte imprimé] / Ju Hee PARK, Auteur ; Young Shin KIM, Auteur ; Yun-Joo KOH, Auteur ; Jungeun SONG, Auteur ; Bennett L. LEVENTHAL, Auteur . - p.1471-1481.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1471-1481
Mots-clés : Autism Spectrum Disorders Comorbid condition Adaptive function BASC-2-PRS Index. décimale : PER Périodiques Résumé : To investigate factors that might hamper early identification of Autism Spectrum Disorder (ASD), the present study examined differences between comorbid conditions and adaptive functions measured by the BASC-2 PRS in an epidemiologically ascertained group of children with ASD (Clinical and Non-clinical ASD groups), those who were screened positive but confirmed not to have ASD (No-ASD), and a group of typical, community children (N = 5222). Results indicate that the Clinical ASD group scored lower on the Externalizing Problems composite, Aggression, and Conduct Problems scales than did the No-ASD group whereas the Non-clinical ASD group did not differ from the other two groups except on the Conduct Problem scale. Further, the Clinical ASD group significantly scored lower than the other two groups the Adaptive Skills composite. The scores of the Clinical ASD group on the Social Skills and Leadership scales were lower than those in the No-ASD group, but not those in the Non-clinical ASD group. Results suggest that the frequent comorbid behavioral problems and higher adaptive skills of children in a non-clinical population, compared to a clinical population could mask their core ASD symptoms, resulting in a delay for caretakers to seek appropriate services for these children. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Pathways to adaptive functioning in autism from early childhood to adolescence / Susie CHANDLER in Autism Research, 15-10 (October 2022)
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Titre : Pathways to adaptive functioning in autism from early childhood to adolescence Type de document : texte imprimé Auteurs : Susie CHANDLER, Auteur ; Virginia CARTER LENO, Auteur ; Phillipa WHITE, Auteur ; Isabel YORKE, Auteur ; Matthew J. HOLLOCKS, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.1883-1893 Langues : Anglais (eng) Mots-clés : Adhd adaptive function autism behavioral problems emotional problems Index. décimale : PER Périodiques Résumé : Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. This study examines longitudinal and contemporaneous associations of adaptive functioning in autistic youth across a wide ability range. Parent-reported autism symptoms, co-occurring emotional, behavioral and attention deficit hyperactivity disorder (ADHD) symptoms, and IQ were assessed in early childhood (M age 7 years; T1) and 6 years later in adolescence (M age 13 years; T2) in 179 autistic youth. Adaptive functioning was assessed at T2. Structural equation modeling estimated pathways to adaptive functioning from autism, and psychiatric symptoms at T1 and T2, testing whether associations were driven by continuity of behaviors from T1 to T2 or their contemporaneous effect at T2, or both, controlling for T1 IQ. Lower adaptive functioning at T2 was associated with higher T1 and T2 ADHD symptoms (Î2 = -0.14, andÎ2 = -0.21) but not behavioral nor emotional symptoms at either timepoint. Lower adaptive functioning at T2 was also associated with lower T1 IQ (Î2 = 0.43) and higher social communication symptoms (Î2 = -0.37) at T2 but not T1, but the relationship with ADHD symptoms remained. Paths were not moderated by sex or IQ. Increased symptoms of ADHD, both in early childhood and contemporaneously, were associated with reduced adaptive functioning in adolescence. Co-occurring ADHD may be a modifiable risk factor for adaptive function impairments and should be routinely assessed and when present evidence-based treatments initiated which may benefit adaptive functioning outcomes. LAY SUMMARY: Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. In a community sample higher attention deficit/hyperactivity disorder (ADHD) symptoms, but not emotional or behavioral symptoms, in both early childhood and contemporaneously were associated with lower adaptive functioning in autistic adolescents. Co-occurring ADHD may be a modifiable risk factor for adaptive function difficulties in autism. En ligne : http://dx.doi.org/10.1002/aur.2785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-10 (October 2022) . - p.1883-1893[article] Pathways to adaptive functioning in autism from early childhood to adolescence [texte imprimé] / Susie CHANDLER, Auteur ; Virginia CARTER LENO, Auteur ; Phillipa WHITE, Auteur ; Isabel YORKE, Auteur ; Matthew J. HOLLOCKS, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Tony CHARMAN, Auteur . - p.1883-1893.
Langues : Anglais (eng)
in Autism Research > 15-10 (October 2022) . - p.1883-1893
Mots-clés : Adhd adaptive function autism behavioral problems emotional problems Index. décimale : PER Périodiques Résumé : Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. This study examines longitudinal and contemporaneous associations of adaptive functioning in autistic youth across a wide ability range. Parent-reported autism symptoms, co-occurring emotional, behavioral and attention deficit hyperactivity disorder (ADHD) symptoms, and IQ were assessed in early childhood (M age 7 years; T1) and 6 years later in adolescence (M age 13 years; T2) in 179 autistic youth. Adaptive functioning was assessed at T2. Structural equation modeling estimated pathways to adaptive functioning from autism, and psychiatric symptoms at T1 and T2, testing whether associations were driven by continuity of behaviors from T1 to T2 or their contemporaneous effect at T2, or both, controlling for T1 IQ. Lower adaptive functioning at T2 was associated with higher T1 and T2 ADHD symptoms (Î2 = -0.14, andÎ2 = -0.21) but not behavioral nor emotional symptoms at either timepoint. Lower adaptive functioning at T2 was also associated with lower T1 IQ (Î2 = 0.43) and higher social communication symptoms (Î2 = -0.37) at T2 but not T1, but the relationship with ADHD symptoms remained. Paths were not moderated by sex or IQ. Increased symptoms of ADHD, both in early childhood and contemporaneously, were associated with reduced adaptive functioning in adolescence. Co-occurring ADHD may be a modifiable risk factor for adaptive function impairments and should be routinely assessed and when present evidence-based treatments initiated which may benefit adaptive functioning outcomes. LAY SUMMARY: Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. In a community sample higher attention deficit/hyperactivity disorder (ADHD) symptoms, but not emotional or behavioral symptoms, in both early childhood and contemporaneously were associated with lower adaptive functioning in autistic adolescents. Co-occurring ADHD may be a modifiable risk factor for adaptive function difficulties in autism. En ligne : http://dx.doi.org/10.1002/aur.2785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Adaptive Behaviors in High-Functioning Taiwanese Children with Autism Spectrum Disorders: an Investigation of the Mediating Roles of Symptom Severity and Cognitive Ability / Chen-Lin CHANG in Journal of Autism and Developmental Disorders, 43-6 (June 2013)
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Titre : Adaptive Behaviors in High-Functioning Taiwanese Children with Autism Spectrum Disorders: an Investigation of the Mediating Roles of Symptom Severity and Cognitive Ability Type de document : texte imprimé Auteurs : Chen-Lin CHANG, Auteur ; For-Wey LUNG, Auteur ; Cheng-Fang YEN, Auteur ; Pinchen YANG, Auteur Article en page(s) : p.1347-1355 Langues : Anglais (eng) Mots-clés : Autism Adaptive function IQ Symptom severity Index. décimale : PER Périodiques Résumé : We investigated the relationship among cognitive level, autistic severity and adaptive function in a Taiwanese sample of 94 high-functioning children with autism spectrum disorders (ASD) (mean full scale intelligent quotients FSIQ = 84.8). Parents and teachers both completed the Adaptive Behavior Assessment System-II and the Social Responsiveness Scale. Correlational and regression analyses were used to explore the relationships among the constructs of cognitive, symptomatic and adaptive domains. Results revealed that average General Adaptive Composites of these children (home: 74.0; school: 74.6) was below average FSIQ. Profile analysis revealed that Social domain was the weakness among the adaptive abilities assessed at school and home. Cognitive abilities had positive relationship with adaptive function, while autistic severity had a weak negative relationship with adaptive function. Also, the younger the age the child got diagnosed, the less severe the current symptoms of autism were. The implication for emphasizing adaptive skills intervention was discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1684-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201
in Journal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1347-1355[article] Adaptive Behaviors in High-Functioning Taiwanese Children with Autism Spectrum Disorders: an Investigation of the Mediating Roles of Symptom Severity and Cognitive Ability [texte imprimé] / Chen-Lin CHANG, Auteur ; For-Wey LUNG, Auteur ; Cheng-Fang YEN, Auteur ; Pinchen YANG, Auteur . - p.1347-1355.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1347-1355
Mots-clés : Autism Adaptive function IQ Symptom severity Index. décimale : PER Périodiques Résumé : We investigated the relationship among cognitive level, autistic severity and adaptive function in a Taiwanese sample of 94 high-functioning children with autism spectrum disorders (ASD) (mean full scale intelligent quotients FSIQ = 84.8). Parents and teachers both completed the Adaptive Behavior Assessment System-II and the Social Responsiveness Scale. Correlational and regression analyses were used to explore the relationships among the constructs of cognitive, symptomatic and adaptive domains. Results revealed that average General Adaptive Composites of these children (home: 74.0; school: 74.6) was below average FSIQ. Profile analysis revealed that Social domain was the weakness among the adaptive abilities assessed at school and home. Cognitive abilities had positive relationship with adaptive function, while autistic severity had a weak negative relationship with adaptive function. Also, the younger the age the child got diagnosed, the less severe the current symptoms of autism were. The implication for emphasizing adaptive skills intervention was discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1684-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201 Comparison of Adaptive Functioning Measures in Adolescents with Autism Spectrum Disorder Without Intellectual Disability / Leanne TAMM in Journal of Autism and Developmental Disorders, 52-3 (March 2022)
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Titre : Comparison of Adaptive Functioning Measures in Adolescents with Autism Spectrum Disorder Without Intellectual Disability Type de document : texte imprimé Auteurs : Leanne TAMM, Auteur ; Haley A. DAY, Auteur ; Amie DUNCAN, Auteur Article en page(s) : p.1247-1256 Langues : Anglais (eng) Mots-clés : Activities of Daily Living Adaptation, Psychological Adolescent Autism Spectrum Disorder/diagnosis Behavior Rating Scale Humans Intellectual Disability/diagnosis/epidemiology Adaptive function Daily living skills High functioning Index. décimale : PER Périodiques Résumé : There is limited literature examining the adaptive functioning of adolescents with autism spectrum disorder (ASD). This study aimed to (a) document Vineland Adaptive Behavior Scales (VABS-3) and Adaptive Behavior Assessment System (ABAS-3) adaptive behavior profiles of adolescents with ASD; (b) examine the comparability of the two measures; and (c) assess potential discrepancies between IQ and adaptive behaviors. Participants included 14- to 18-year-olds with ASD without intellectual disability. Significant adaptive skills deficits were observed with most scores at least one standard deviation below the mean. Relative weaknesses were observed for social and daily living skills. The absolute magnitude of VABS-3 and ABAS-3 scores differed. There were significant discrepancies between IQ and adaptive functioning. These findings have implications for clinicians and researchers. En ligne : http://dx.doi.org/10.1007/s10803-021-05013-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1247-1256[article] Comparison of Adaptive Functioning Measures in Adolescents with Autism Spectrum Disorder Without Intellectual Disability [texte imprimé] / Leanne TAMM, Auteur ; Haley A. DAY, Auteur ; Amie DUNCAN, Auteur . - p.1247-1256.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1247-1256
Mots-clés : Activities of Daily Living Adaptation, Psychological Adolescent Autism Spectrum Disorder/diagnosis Behavior Rating Scale Humans Intellectual Disability/diagnosis/epidemiology Adaptive function Daily living skills High functioning Index. décimale : PER Périodiques Résumé : There is limited literature examining the adaptive functioning of adolescents with autism spectrum disorder (ASD). This study aimed to (a) document Vineland Adaptive Behavior Scales (VABS-3) and Adaptive Behavior Assessment System (ABAS-3) adaptive behavior profiles of adolescents with ASD; (b) examine the comparability of the two measures; and (c) assess potential discrepancies between IQ and adaptive behaviors. Participants included 14- to 18-year-olds with ASD without intellectual disability. Significant adaptive skills deficits were observed with most scores at least one standard deviation below the mean. Relative weaknesses were observed for social and daily living skills. The absolute magnitude of VABS-3 and ABAS-3 scores differed. There were significant discrepancies between IQ and adaptive functioning. These findings have implications for clinicians and researchers. En ligne : http://dx.doi.org/10.1007/s10803-021-05013-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome / Armin RAZNAHAN in Journal of Neurodevelopmental Disorders, 15 (2023)
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Titre : Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome Type de document : texte imprimé Auteurs : Armin RAZNAHAN, Auteur ; Srishti RAU, Auteur ; Luke SCHAFFER, Auteur ; Siyuan LIU, Auteur ; Ari M. FISH, Auteur ; Catherine MANKIW, Auteur ; Anastasia XENOPHONTOS, Auteur ; Liv S. CLASEN, Auteur ; Lisa JOSEPH, Auteur ; Audrey THURM, Auteur ; Jonathan D. BLUMENTHAL, Auteur ; Dani S. BASSETT, Auteur ; Erin N. TORRES, Auteur Langues : Anglais (eng) Mots-clés : Humans Male XYY Karyotype Sex Chromosome Disorders/diagnosis Cognition Phenotype Adaptive function Behavioral phenotyping Deep phenotyping Neurogenetics Sex chromosomes Symptom networks Index. décimale : PER Périodiques Résumé : BACKGROUND: Recurrent gene dosage disorders impart substantial risk for psychopathology. Yet, understanding that risk is hampered by complex presentations that challenge classical diagnostic systems. Here, we present a suite of generalizable analytic approaches for parsing this clinical complexity, which we illustrate through application to XYY syndrome. METHOD: We gathered high-dimensional measures of psychopathology in 64 XYY individuals and 60 XY controls, plus additional interviewer-based diagnostic data in the XYY group. We provide the first comprehensive diagnostic description of psychiatric morbidity in XYY syndrome and show how diagnostic morbidity relates to functioning, subthreshold symptoms, and ascertainment bias. We then map behavioral vulnerabilities and resilience across 67 behavioral dimensions before borrowing techniques from network science to resolve the mesoscale architecture of these dimensions and links to observable functional outcomes. RESULTS: Carriage of an extra Y-chromosome increases risk for diverse psychiatric diagnoses, with clinically impactful subthreshold symptomatology. Highest rates are seen for neurodevelopmental and affective disorders. A lower bound of < 25% of carriers are free of any diagnosis. Dimensional analysis of 67 scales details the profile of psychopathology in XYY, which survives control for ascertainment bias, specifies attentional and social domains as the most impacted, and refutes stigmatizing historical associations between XYY and violence. Network modeling compresses all measured symptom scales into 8 modules with dissociable links to cognitive ability, adaptive function, and caregiver strain. Hub modules offer efficient proxies for the full symptom network. CONCLUSIONS: This study parses the complex behavioral phenotype of XYY syndrome by applying new and generalizable analytic approaches for analysis of deep-phenotypic psychiatric data in neurogenetic disorders. En ligne : https://dx.doi.org/10.1186/s11689-023-09476-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575
in Journal of Neurodevelopmental Disorders > 15 (2023)[article] Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome [texte imprimé] / Armin RAZNAHAN, Auteur ; Srishti RAU, Auteur ; Luke SCHAFFER, Auteur ; Siyuan LIU, Auteur ; Ari M. FISH, Auteur ; Catherine MANKIW, Auteur ; Anastasia XENOPHONTOS, Auteur ; Liv S. CLASEN, Auteur ; Lisa JOSEPH, Auteur ; Audrey THURM, Auteur ; Jonathan D. BLUMENTHAL, Auteur ; Dani S. BASSETT, Auteur ; Erin N. TORRES, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 15 (2023)
Mots-clés : Humans Male XYY Karyotype Sex Chromosome Disorders/diagnosis Cognition Phenotype Adaptive function Behavioral phenotyping Deep phenotyping Neurogenetics Sex chromosomes Symptom networks Index. décimale : PER Périodiques Résumé : BACKGROUND: Recurrent gene dosage disorders impart substantial risk for psychopathology. Yet, understanding that risk is hampered by complex presentations that challenge classical diagnostic systems. Here, we present a suite of generalizable analytic approaches for parsing this clinical complexity, which we illustrate through application to XYY syndrome. METHOD: We gathered high-dimensional measures of psychopathology in 64 XYY individuals and 60 XY controls, plus additional interviewer-based diagnostic data in the XYY group. We provide the first comprehensive diagnostic description of psychiatric morbidity in XYY syndrome and show how diagnostic morbidity relates to functioning, subthreshold symptoms, and ascertainment bias. We then map behavioral vulnerabilities and resilience across 67 behavioral dimensions before borrowing techniques from network science to resolve the mesoscale architecture of these dimensions and links to observable functional outcomes. RESULTS: Carriage of an extra Y-chromosome increases risk for diverse psychiatric diagnoses, with clinically impactful subthreshold symptomatology. Highest rates are seen for neurodevelopmental and affective disorders. A lower bound of < 25% of carriers are free of any diagnosis. Dimensional analysis of 67 scales details the profile of psychopathology in XYY, which survives control for ascertainment bias, specifies attentional and social domains as the most impacted, and refutes stigmatizing historical associations between XYY and violence. Network modeling compresses all measured symptom scales into 8 modules with dissociable links to cognitive ability, adaptive function, and caregiver strain. Hub modules offer efficient proxies for the full symptom network. CONCLUSIONS: This study parses the complex behavioral phenotype of XYY syndrome by applying new and generalizable analytic approaches for analysis of deep-phenotypic psychiatric data in neurogenetic disorders. En ligne : https://dx.doi.org/10.1186/s11689-023-09476-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 The neurodevelopmental spectrum of CASK-related disorder / Jessica MARTIN in Journal of Neurodevelopmental Disorders, 17 (2025)
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PermalinkAccelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study / Zoe HAWKS in Journal of Autism and Developmental Disorders, 50-1 (January 2020)
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