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An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions / Y. C. CHEN in Autism Research, 14-11 (November 2021)
[article]
Titre : An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur Article en page(s) : p.2287-2299 Langues : Anglais (eng) Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2287-2299[article] An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions [Texte imprimé et/ou numérique] / Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur . - p.2287-2299.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2287-2299
Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood / S. THIJSSEN in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
[article]
Titre : The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur Article en page(s) : p.857-867 Langues : Anglais (eng) Mots-clés : Adolescent Adult Amygdala/diagnostic imaging Gyrus Cinguli Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging Prefrontal Cortex/diagnostic imaging Young Adult Externalizing behavior amygdala anterior cingulate cortex functional connectivity orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867[article] The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood [Texte imprimé et/ou numérique] / S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur . - p.857-867.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867
Mots-clés : Adolescent Adult Amygdala/diagnostic imaging Gyrus Cinguli Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging Prefrontal Cortex/diagnostic imaging Young Adult Externalizing behavior amygdala anterior cingulate cortex functional connectivity orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456