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Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors / N. M. FAVA in Development and Psychopathology, 31-4 (October 2019)
[article]
Titre : Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors Type de document : Texte imprimé et/ou numérique Auteurs : N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur Article en page(s) : p.1439-1450 Langues : Anglais (eng) Mots-clés : anterior cingulate cortex childhood adversity externalizing behavior inhibitory control substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406
in Development and Psychopathology > 31-4 (October 2019) . - p.1439-1450[article] Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors [Texte imprimé et/ou numérique] / N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur . - p.1439-1450.
Langues : Anglais (eng)
in Development and Psychopathology > 31-4 (October 2019) . - p.1439-1450
Mots-clés : anterior cingulate cortex childhood adversity externalizing behavior inhibitory control substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / C. LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)
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Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults Anterior cingulate cortex Autism Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409[article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [Texte imprimé et/ou numérique] / C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur . - p.1402-1409.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409
Mots-clés : Adults Anterior cingulate cortex Autism Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism / Chie SHIMMURA in Molecular Autism, (March 2013)
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Titre : Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism Type de document : Texte imprimé et/ou numérique Auteurs : Chie SHIMMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Yasuhide IWATA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Koji OHNO, Auteur ; Hideo MATSUZAKI, Auteur ; Keiko IWATA, Auteur ; Yosuke KAMENO, Auteur ; Taro TAKAHASHI, Auteur ; Tomoyasu WAKUDA, Auteur ; Kazuhiko NAKAMURA, Auteur ; Kenji HASHIMOTO, Auteur ; Norio MORI, Auteur Année de publication : 2013 Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism Glutamate Glutaminase Glutamate-glutamine cycle Anterior cingulate cortex Index. décimale : PER Périodiques Résumé : BACKGROUND:Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamatergic neurotransmission. We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism.METHODS:We performed Western blot analyses for the protein expression levels of enzymes in the glutamate-glutamine cycle, including glutamine synthetase, kidney-type glutaminase, liver-type glutaminase, and glutamate dehydrogenases 1 and 2, in the ACC of postmortem brain of individuals with autism (n=7) and control subjects (n=13).RESULTS:We found that the protein levels of kidney-type glutaminase, but not those of the other enzymes measured, in the ACC were significantly lower in subjects with autism than in controls.CONCLUSION:The results suggest that reduced expression of kidney-type glutaminase may account for putative alterations in glutamatergic neurotransmission in the ACC in autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (March 2013) . - 7 p.[article] Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism [Texte imprimé et/ou numérique] / Chie SHIMMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Yasuhide IWATA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Koji OHNO, Auteur ; Hideo MATSUZAKI, Auteur ; Keiko IWATA, Auteur ; Yosuke KAMENO, Auteur ; Taro TAKAHASHI, Auteur ; Tomoyasu WAKUDA, Auteur ; Kazuhiko NAKAMURA, Auteur ; Kenji HASHIMOTO, Auteur ; Norio MORI, Auteur . - 2013 . - 7 p.
Langues : Anglais (eng)
in Molecular Autism > (March 2013) . - 7 p.
Mots-clés : Autism Glutamate Glutaminase Glutamate-glutamine cycle Anterior cingulate cortex Index. décimale : PER Périodiques Résumé : BACKGROUND:Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamatergic neurotransmission. We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism.METHODS:We performed Western blot analyses for the protein expression levels of enzymes in the glutamate-glutamine cycle, including glutamine synthetase, kidney-type glutaminase, liver-type glutaminase, and glutamate dehydrogenases 1 and 2, in the ACC of postmortem brain of individuals with autism (n=7) and control subjects (n=13).RESULTS:We found that the protein levels of kidney-type glutaminase, but not those of the other enzymes measured, in the ACC were significantly lower in subjects with autism than in controls.CONCLUSION:The results suggest that reduced expression of kidney-type glutaminase may account for putative alterations in glutamatergic neurotransmission in the ACC in autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity / Ran LIU in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)
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Titre : Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1037-1044 Langues : Anglais (eng) Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044[article] Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur . - p.1037-1044.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044
Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 Brain response to viewing others being harmed in children with conduct disorder symptoms / Kalina J. MICHALSKA in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)
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Titre : Brain response to viewing others being harmed in children with conduct disorder symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Kalina J. MICHALSKA, Auteur ; Thomas A. ZEFFIRO, Auteur ; Jean DECETY, Auteur Article en page(s) : p.510-519 Langues : Anglais (eng) Mots-clés : Conduct disorder callousness affective arousal emotional empathy insula anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Deficient empathic processing is thought to foster conduct disorder (CD). It is important to determine the extent to which neural response associated with perceiving harm to others predicts CD symptoms and callous disregard for others. Methods A total of 107 9- to 11-year-old children (52 female) were recruited from pediatric and mental health clinics, representing a wide range of CD symptoms. Children were scanned with functional magnetic resonance imaging while viewing brief video clips of persons being harmed intentionally or accidentally. Results Perceiving harm evoked increased hemodynamic response in the anterior insula (aINS), anterior cingulate cortex (ACC), amygdala, periaqueductal gray (PAG), caudate, and inferior parietal lobe (IPL) across all participants. Intentionally caused, relative to unintentional harm was associated with greater activity in the aINS, amygdala, and temporal pole. There was an inverse association of number of CD symptoms with right posterior insula in both the Harm > No Harm and the Intentional > Unintentional Harm contrasts. Furthermore, an inverse association between callousness and posterior insula activation was found in the Harm > No Harm contrast, with the opposite pattern for reactive aggression scores. An interaction revealed a stronger association in girls between CD symptoms and the right posterior superior temporal sulcus (pSTS) in the Intentional Harm versus Unintentional Harm contrast. Conclusions Children with greater CD and callousness exhibit dampened hemodynamic response to viewing others being harmed in the insula, a region which plays a key role in empathy and emotional awareness. Sex differences in the neural correlates of CD were observed. En ligne : http://dx.doi.org/10.1111/jcpp.12474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.510-519[article] Brain response to viewing others being harmed in children with conduct disorder symptoms [Texte imprimé et/ou numérique] / Kalina J. MICHALSKA, Auteur ; Thomas A. ZEFFIRO, Auteur ; Jean DECETY, Auteur . - p.510-519.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.510-519
Mots-clés : Conduct disorder callousness affective arousal emotional empathy insula anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Deficient empathic processing is thought to foster conduct disorder (CD). It is important to determine the extent to which neural response associated with perceiving harm to others predicts CD symptoms and callous disregard for others. Methods A total of 107 9- to 11-year-old children (52 female) were recruited from pediatric and mental health clinics, representing a wide range of CD symptoms. Children were scanned with functional magnetic resonance imaging while viewing brief video clips of persons being harmed intentionally or accidentally. Results Perceiving harm evoked increased hemodynamic response in the anterior insula (aINS), anterior cingulate cortex (ACC), amygdala, periaqueductal gray (PAG), caudate, and inferior parietal lobe (IPL) across all participants. Intentionally caused, relative to unintentional harm was associated with greater activity in the aINS, amygdala, and temporal pole. There was an inverse association of number of CD symptoms with right posterior insula in both the Harm > No Harm and the Intentional > Unintentional Harm contrasts. Furthermore, an inverse association between callousness and posterior insula activation was found in the Harm > No Harm contrast, with the opposite pattern for reactive aggression scores. An interaction revealed a stronger association in girls between CD symptoms and the right posterior superior temporal sulcus (pSTS) in the Intentional Harm versus Unintentional Harm contrast. Conclusions Children with greater CD and callousness exhibit dampened hemodynamic response to viewing others being harmed in the insula, a region which plays a key role in empathy and emotional awareness. Sex differences in the neural correlates of CD were observed. En ligne : http://dx.doi.org/10.1111/jcpp.12474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Increased prefrontal GABA concentrations in adults with autism spectrum disorders / Simon MAIER in Autism Research, 15-7 (July 2022)
PermalinkNeural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders / Tomoyo MORITA in Research in Autism Spectrum Disorders, 26 (June 2016)
PermalinkThe longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood / S. THIJSSEN in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
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