7 recherche sur le mot-clé 'Asymmetry'

Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity / Chase C. DOUGHERTY in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 28p. Titre : Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity Type de document : texte imprimé Auteurs : Chase C. DOUGHERTY, Auteur ; David W. EVANS, Auteur ; Gajendra J. KATUWAL, Auteur ; Andrew M. MICHAEL, Auteur Article en page(s) : 28p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Algorithms  Autism Spectrum Disorder/diagnostic imaging/pathology  Child  Cross-Sectional Studies  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Severity of Illness Index  Temporal Lobe/anatomy & histology  Young Adult  Asymmetry  Autism spectrum disorder  Development  Fusiform gyrus  Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity [texte imprimé] / Chase C. DOUGHERTY, Auteur ; David W. EVANS, Auteur ; Gajendra J. KATUWAL, Auteur ; Andrew M. MICHAEL, Auteur . - 28p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 28p. Mots-clés : Adolescent  Adult  Algorithms  Autism Spectrum Disorder/diagnostic imaging/pathology  Child  Cross-Sectional Studies  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Severity of Illness Index  Temporal Lobe/anatomy & histology  Young Adult  Asymmetry  Autism spectrum disorder  Development  Fusiform gyrus  Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

EEG spectral characteristics and asymmetry in pre-school children with autism in awake and sleep stages / Sowmyashree Mayur KAKU ; Anoop JOSEPH ; Manjula William JAMES ; Gosala R.K. SARMA ; Ashok MYSORE ; Shyam Sundar RAJAGOPALAN in Research in Autism, 121-122 (March-April 2025)  

Public ISBD [article]  inResearch in Autism > 121-122 (March-April 2025) . - 202538 Titre : EEG spectral characteristics and asymmetry in pre-school children with autism in awake and sleep stages Type de document : texte imprimé Auteurs : Sowmyashree Mayur KAKU, Auteur ; Anoop JOSEPH, Auteur ; Manjula William JAMES, Auteur ; Gosala R.K. SARMA, Auteur ; Ashok MYSORE, Auteur ; Shyam Sundar RAJAGOPALAN, Auteur Article en page(s) : 202538 Langues : Anglais (eng) Mots-clés : Autism  Preschool  Electroencephalogram  EEG  NREM  Sleep stage  Asymmetry  Power spectral density  Band power Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex-heterogeneous neurodevelopmental disorder manifesting as abnormalities in social communication and repetitive behaviors, generally observed from early childhood. These syndromic behaviors have neurophysiological basis which stems from altered activations of cortical structures in the pathways of functional neural networks and regulatory mechanisms. Frequency bands of Electroencephalography (EEG) have functional and topographical significance expressed through computed parameters like band power and asymmetry index. Previous studies have mapped these parameters to ASD symptoms, limited to select cortical locations, bands and restricted study conditions in either passive awake or selected sleep stage. Methods Spontaneous EEG recorded from two clinically diagnosed groups of preschoolers, ASD and non-ASD in awake and 3 stages of Non-Rapid Eye Movement (NREM) sleep (N1-N3) was decomposed into 8 frequency bands spanning 0.5-24 Hz. Band powers were computed for 60 channels and hemispheric asymmetry index (AI) for 12 regions covering the entire scalp. Results We found awake alpha with N1 slow and fast theta powers significantly lower for ASD. N1 fast beta power was higher in ASD. Sleep AI exhibited significant dominance with both groups displaying congruent orientation in N1 and contralateral in N2 and N3. ASD showed lower AI in N1 and N3 with higher AI in N2. Conclusion Cyclical states of awake and sleep often tend to project their mental processes from one onto another making a use case for our pervasive approach. This pilot study highlights the need to include EEG spectral parameters into the heterogeneous relationship of awake/sleep states mentation, neuropsychology and ASD symptoms. En ligne : https://doi.org/10.1016/j.reia.2025.202538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] EEG spectral characteristics and asymmetry in pre-school children with autism in awake and sleep stages [texte imprimé] / Sowmyashree Mayur KAKU, Auteur ; Anoop JOSEPH, Auteur ; Manjula William JAMES, Auteur ; Gosala R.K. SARMA, Auteur ; Ashok MYSORE, Auteur ; Shyam Sundar RAJAGOPALAN, Auteur . - 202538. Langues : Anglais (eng) in Research in Autism > 121-122 (March-April 2025) . - 202538 Mots-clés : Autism  Preschool  Electroencephalogram  EEG  NREM  Sleep stage  Asymmetry  Power spectral density  Band power Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex-heterogeneous neurodevelopmental disorder manifesting as abnormalities in social communication and repetitive behaviors, generally observed from early childhood. These syndromic behaviors have neurophysiological basis which stems from altered activations of cortical structures in the pathways of functional neural networks and regulatory mechanisms. Frequency bands of Electroencephalography (EEG) have functional and topographical significance expressed through computed parameters like band power and asymmetry index. Previous studies have mapped these parameters to ASD symptoms, limited to select cortical locations, bands and restricted study conditions in either passive awake or selected sleep stage. Methods Spontaneous EEG recorded from two clinically diagnosed groups of preschoolers, ASD and non-ASD in awake and 3 stages of Non-Rapid Eye Movement (NREM) sleep (N1-N3) was decomposed into 8 frequency bands spanning 0.5-24 Hz. Band powers were computed for 60 channels and hemispheric asymmetry index (AI) for 12 regions covering the entire scalp. Results We found awake alpha with N1 slow and fast theta powers significantly lower for ASD. N1 fast beta power was higher in ASD. Sleep AI exhibited significant dominance with both groups displaying congruent orientation in N1 and contralateral in N2 and N3. ASD showed lower AI in N1 and N3 with higher AI in N2. Conclusion Cyclical states of awake and sleep often tend to project their mental processes from one onto another making a use case for our pervasive approach. This pilot study highlights the need to include EEG spectral parameters into the heterogeneous relationship of awake/sleep states mentation, neuropsychology and ASD symptoms. En ligne : https://doi.org/10.1016/j.reia.2025.202538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders / Amy Vaughan VAN HECKE in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335 Titre : Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget K. DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur Article en page(s) : p.316-335 Langues : Anglais (eng) Mots-clés : Autism  Adolescence  EEG  Asymmetry  PEERS  Intervention  Brain  Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders [texte imprimé] / Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget K. DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur . - p.316-335. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335 Mots-clés : Autism  Adolescence  EEG  Asymmetry  PEERS  Intervention  Brain  Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited / Dorothea L. FLORIS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772 Titre : Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur Article en page(s) : p.1758-1772 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum  Handedness  Asymmetry  Lateralization  Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 [article] Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited [texte imprimé] / Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur . - p.1758-1772. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772 Mots-clés : Autism  Corpus callosum  Handedness  Asymmetry  Lateralization  Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205

Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach / Daniel E. LIDSTONE in Research in Autism Spectrum Disorders, 73 (May 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 73 (May 2019) . - 101546 Titre : Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach Type de document : texte imprimé Auteurs : Daniel E. LIDSTONE, Auteur ; Faria Z. MIAH, Auteur ; Brach POSTON, Auteur ; Julie F. BEASLEY, Auteur ; Janet S. DUFEK, Auteur Article en page(s) : 101546 Langues : Anglais (eng) Mots-clés : Cross-syndrome  Manual dexterity  FASD  ASD  Asymmetry Index. décimale : PER Périodiques Résumé : Background Manual dexterity (MD) is important for performing most activities of daily living, and children with ASD show MD deficits. However, the specificity of MD deficits in children with ASD has not previously been examined. Similar to children with ASD, extant evidence suggests children with Fetal Alcohol Spectrum Disorder (FASD) and Attention-Deficit Hyperactivity Disorder (ADHD) also show MD impairments. The purpose of this study was to examine the specificity MD deficits in children with ASD using a cross-syndrome design. We examined dominant (D) and non-dominant (ND) hand performance using a relatively large sample of children with ASD, FASD, ADHD, and typically developing (TD) children. Method Seventy-two right-handed children (7–17 years old) participated in this study. To examine MD, the 9-hole pegboard test was completed on the D and ND-hands. The fastest time of three attempts was recorded. HPA was defined as the percent difference between D and ND-hand times. Results D-hand MD was significantly worse in children with ASD vs. typically developing (TD) children (p = 0.002). ND-hand dexterity was significantly worse in children with ASD vs. FASD (p = 0.049) and TD groups (p = 0.004). Hand performance asymmetry (HPA) was significantly lower in the FASD group compared to both the ASD and ADHD groups (p < 0.05). Conclusions These results show that children with ASD show specific deficits in MD not observed in children with FASD or ADHD. Furthermore, HPA was found to be a sensitive measure to prenatal alcohol exposure. Neurobiological mechanisms of ASD and FASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2020.101546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach [texte imprimé] / Daniel E. LIDSTONE, Auteur ; Faria Z. MIAH, Auteur ; Brach POSTON, Auteur ; Julie F. BEASLEY, Auteur ; Janet S. DUFEK, Auteur . - 101546. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101546 Mots-clés : Cross-syndrome  Manual dexterity  FASD  ASD  Asymmetry Index. décimale : PER Périodiques Résumé : Background Manual dexterity (MD) is important for performing most activities of daily living, and children with ASD show MD deficits. However, the specificity of MD deficits in children with ASD has not previously been examined. Similar to children with ASD, extant evidence suggests children with Fetal Alcohol Spectrum Disorder (FASD) and Attention-Deficit Hyperactivity Disorder (ADHD) also show MD impairments. The purpose of this study was to examine the specificity MD deficits in children with ASD using a cross-syndrome design. We examined dominant (D) and non-dominant (ND) hand performance using a relatively large sample of children with ASD, FASD, ADHD, and typically developing (TD) children. Method Seventy-two right-handed children (7–17 years old) participated in this study. To examine MD, the 9-hole pegboard test was completed on the D and ND-hands. The fastest time of three attempts was recorded. HPA was defined as the percent difference between D and ND-hand times. Results D-hand MD was significantly worse in children with ASD vs. typically developing (TD) children (p = 0.002). ND-hand dexterity was significantly worse in children with ASD vs. FASD (p = 0.049) and TD groups (p = 0.004). Hand performance asymmetry (HPA) was significantly lower in the FASD group compared to both the ASD and ADHD groups (p < 0.05). Conclusions These results show that children with ASD show specific deficits in MD not observed in children with FASD or ADHD. Furthermore, HPA was found to be a sensitive measure to prenatal alcohol exposure. Neurobiological mechanisms of ASD and FASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2020.101546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Reduced lateralization of multiple functional brain networks in autistic males / Madeline PETERSON in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study / Monika TRINKL in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

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