13 recherche sur le mot-clé 'Auditory Perception/physiology'

Auditory processing in rodent models of autism: a systematic review / Maya WILDE in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Auditory processing in rodent models of autism: a systematic review Type de document : texte imprimé Auteurs : Maya WILDE, Auteur ; Lena CONSTANTIN, Auteur ; Peter R THORNE, Auteur ; Johanna M MONTGOMERY, Auteur ; Ethan K SCOTT, Auteur ; Juliette E CHEYNE, Auteur Langues : Anglais (eng) Mots-clés : Animals  Auditory Perception/physiology  Autistic Disorder  Electroencephalography/methods  Evoked Potentials, Auditory, Brain Stem  Humans  Mice  Rats  Rodentia  Auditory  Auditory brainstem recordings  Autism spectrum disorder  Cortical event-related potentials  Rodent models Index. décimale : PER Périodiques Résumé : Autism is a complex condition with many traits, including differences in auditory sensitivity. Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas studies in individual rodent models cannot represent the full spectrum of human autism. This systematic review compares results in auditory studies across a wide range of established rodent models of autism to mimic the wide range of aetiologies in the human population. A search was conducted in the PubMed and Web of Science databases to find primary research articles in mouse or rat models of autism which investigate central auditory processing. A total of 88 studies were included. These used non-invasive measures of auditory function, such as auditory brainstem response recordings, cortical event-related potentials, electroencephalography, and behavioural tests, which are translatable to human studies. They also included invasive measures, such as electrophysiology and histology, which shed insight on the origins of the phenotypes found in the non-invasive studies. The most consistent results across these studies were increased latency of the N1 peak of event-related potentials, decreased power and coherence of gamma activity in the auditory cortex, and increased auditory startle responses to high sound levels. Invasive studies indicated loss of subcortical inhibitory neurons, hyperactivity in the lateral superior olive and auditory thalamus, and reduced specificity of responses in the auditory cortex. This review compares the auditory phenotypes across rodent models and highlights those that mimic findings in human studies, providing a framework and avenues for future studies to inform understanding of the auditory system in autism. En ligne : https://dx.doi.org/10.1186/s11689-022-09458-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Auditory processing in rodent models of autism: a systematic review [texte imprimé] / Maya WILDE, Auteur ; Lena CONSTANTIN, Auteur ; Peter R THORNE, Auteur ; Johanna M MONTGOMERY, Auteur ; Ethan K SCOTT, Auteur ; Juliette E CHEYNE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Animals  Auditory Perception/physiology  Autistic Disorder  Electroencephalography/methods  Evoked Potentials, Auditory, Brain Stem  Humans  Mice  Rats  Rodentia  Auditory  Auditory brainstem recordings  Autism spectrum disorder  Cortical event-related potentials  Rodent models Index. décimale : PER Périodiques Résumé : Autism is a complex condition with many traits, including differences in auditory sensitivity. Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas studies in individual rodent models cannot represent the full spectrum of human autism. This systematic review compares results in auditory studies across a wide range of established rodent models of autism to mimic the wide range of aetiologies in the human population. A search was conducted in the PubMed and Web of Science databases to find primary research articles in mouse or rat models of autism which investigate central auditory processing. A total of 88 studies were included. These used non-invasive measures of auditory function, such as auditory brainstem response recordings, cortical event-related potentials, electroencephalography, and behavioural tests, which are translatable to human studies. They also included invasive measures, such as electrophysiology and histology, which shed insight on the origins of the phenotypes found in the non-invasive studies. The most consistent results across these studies were increased latency of the N1 peak of event-related potentials, decreased power and coherence of gamma activity in the auditory cortex, and increased auditory startle responses to high sound levels. Invasive studies indicated loss of subcortical inhibitory neurons, hyperactivity in the lateral superior olive and auditory thalamus, and reduced specificity of responses in the auditory cortex. This review compares the auditory phenotypes across rodent models and highlights those that mimic findings in human studies, providing a framework and avenues for future studies to inform understanding of the auditory system in autism. En ligne : https://dx.doi.org/10.1186/s11689-022-09458-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study / Anna REBREIKINA ; Victoria VOINOVA ; Olga SYSOEVA in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 40 p. Titre : Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study Type de document : texte imprimé Auteurs : Anna REBREIKINA, Auteur ; Victoria VOINOVA, Auteur ; Olga SYSOEVA, Auteur Article en page(s) : 40 p. Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Adolescent  *Rett Syndrome/diagnosis/genetics  Evoked Potentials, Auditory/physiology  Acoustic Stimulation  Evoked Potentials  Electroencephalography  Auditory Perception/physiology  Auditory event-related potential (ERP)  Presentation rate  Rett syndrome  Stimulus-specific adaptation Index. décimale : PER Périodiques Résumé : BACKGROUND: Rett syndrome (RS) is a rare neurodevelopmental disorder characterized by mutations in the MECP2 gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Neurophysiological correlates of auditory processing have been also found to be distorted in RS, but sound presentation rates were relatively quick in these studies (stimulus onset asynchrony, SOA<1000 ms). As auditory event-related potential (ERP) is typically increased with prolongation of SOA we aim to study if SOA prolongation might compensate for observed abnormalities. METHODS: We presented a repetitive stimulus (1000 Hz) at three different SOAs of 900 ms, 1800 ms, and 3600 ms in children with RS (N=24, Mean age=9.0+3.1) and their typical development (TD) peers (N=27, Mean age=9.7+3.4) while recording 28-channels electroencephalogram, EEG. Some RS participants (n=10) did not show clear ERP and were excluded from the analysis. RESULTS: Major ERP components (here assessed as N1P1 and P2N1 peak-to-peak values) were smaller at SOA 900 than at longer SOAs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in at least in RS patients with evident ERPs. At the same time the latencies of these components were significantly delayed in the RS than in TD. Moreover, late components (P2N1 and N2P2) were drastically reduced in Rett syndrome irrespective of the SOA, suggesting a largely affected mechanism of integration of upcoming sensory input with memory. Moreover, developmental stagnation of auditory ERP characterized patients with RS: absence of typical P2N1 enlargement and P1 and N1 shortening with age at least for shortest SOA. LIMITATIONS: We could not figure out the cause for the high percentage of no-evident ERP RS participants and our final sample of the RS group was rather small. Also, our study did not include a control clinical group. CONCLUSIONS: Thus, auditory ERPs inform us about abnormalities within auditory processing that cannot be fully overcomed by slowing presentation rate. En ligne : https://dx.doi.org/10.1186/s13229-023-00566-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Effect of presentation rate on auditory processing in Rett syndrome: event-related potential study [texte imprimé] / Anna REBREIKINA, Auteur ; Victoria VOINOVA, Auteur ; Olga SYSOEVA, Auteur . - 40 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 40 p. Mots-clés : Child  Humans  Child, Preschool  Adolescent  *Rett Syndrome/diagnosis/genetics  Evoked Potentials, Auditory/physiology  Acoustic Stimulation  Evoked Potentials  Electroencephalography  Auditory Perception/physiology  Auditory event-related potential (ERP)  Presentation rate  Rett syndrome  Stimulus-specific adaptation Index. décimale : PER Périodiques Résumé : BACKGROUND: Rett syndrome (RS) is a rare neurodevelopmental disorder characterized by mutations in the MECP2 gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Neurophysiological correlates of auditory processing have been also found to be distorted in RS, but sound presentation rates were relatively quick in these studies (stimulus onset asynchrony, SOA<1000 ms). As auditory event-related potential (ERP) is typically increased with prolongation of SOA we aim to study if SOA prolongation might compensate for observed abnormalities. METHODS: We presented a repetitive stimulus (1000 Hz) at three different SOAs of 900 ms, 1800 ms, and 3600 ms in children with RS (N=24, Mean age=9.0+3.1) and their typical development (TD) peers (N=27, Mean age=9.7+3.4) while recording 28-channels electroencephalogram, EEG. Some RS participants (n=10) did not show clear ERP and were excluded from the analysis. RESULTS: Major ERP components (here assessed as N1P1 and P2N1 peak-to-peak values) were smaller at SOA 900 than at longer SOAs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in at least in RS patients with evident ERPs. At the same time the latencies of these components were significantly delayed in the RS than in TD. Moreover, late components (P2N1 and N2P2) were drastically reduced in Rett syndrome irrespective of the SOA, suggesting a largely affected mechanism of integration of upcoming sensory input with memory. Moreover, developmental stagnation of auditory ERP characterized patients with RS: absence of typical P2N1 enlargement and P1 and N1 shortening with age at least for shortest SOA. LIMITATIONS: We could not figure out the cause for the high percentage of no-evident ERP RS participants and our final sample of the RS group was rather small. Also, our study did not include a control clinical group. CONCLUSIONS: Thus, auditory ERPs inform us about abnormalities within auditory processing that cannot be fully overcomed by slowing presentation rate. En ligne : https://dx.doi.org/10.1186/s13229-023-00566-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Increased context adjustment is associated with auditory sensitivities but not with autistic traits / Roshini RANDENIYA in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1457-1468 Titre : Increased context adjustment is associated with auditory sensitivities but not with autistic traits Type de document : texte imprimé Auteurs : Roshini RANDENIYA, Auteur ; Jason B. MATTINGLEY, Auteur ; Marta I. GARRIDO, Auteur Article en page(s) : p.1457-1468 Langues : Anglais (eng) Mots-clés : Acoustic Stimulation/methods  Auditory Perception/physiology  Autism Spectrum Disorder  Bayes Theorem  Electroencephalography  Evoked Potentials, Auditory/physiology  Humans  Bayesian  Eeg  Mmn  atypical perception  autism  precision  prediction errors  predictive coding Index. décimale : PER Périodiques Résumé : Bayesian models of autism suggest that alterations in context-sensitive prediction error weighting may underpin sensory perceptual alterations, such as hypersensitivities. We used an auditory oddball paradigm with pure tones arising from high or low uncertainty contexts to determine whether autistic individuals display differences in context adjustment relative to neurotypicals. We did not find group differences in early prediction error responses indexed by mismatch negativity. A dimensional approach revealed a positive correlation between context-dependent prediction errors and subjective reports of auditory sensitivities, but not with autistic traits. These findings suggest that autism studies may benefit from accounting for sensory sensitivities in group comparisons. LAY SUMMARY: We aimed to understand if autistic and non-autistic groups showed differences in their electrical brain activity measured by electroencephalography (EEG) when listening to surprising tones infrequently embedded in a statistical pattern. We found no differences between the autistic and the non-autistic group in their EEG response to the surprising sound even if the pattern switched, indicating their ability to learn a pattern. We did find that, as subjective sensory sensitivities (but not autistic traits) increased, there were increasingly large differences between the EEG responses to surprising tones that were embedded in the different statistical patterns of tones. These findings show that perceptual alterations may be a function of sensory sensitivities, but not necessarily autistic traits. We suggest that future EEG studies in autism may benefit from accounting for sensory sensitivities. En ligne : http://dx.doi.org/10.1002/aur.2759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Increased context adjustment is associated with auditory sensitivities but not with autistic traits [texte imprimé] / Roshini RANDENIYA, Auteur ; Jason B. MATTINGLEY, Auteur ; Marta I. GARRIDO, Auteur . - p.1457-1468. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1457-1468 Mots-clés : Acoustic Stimulation/methods  Auditory Perception/physiology  Autism Spectrum Disorder  Bayes Theorem  Electroencephalography  Evoked Potentials, Auditory/physiology  Humans  Bayesian  Eeg  Mmn  atypical perception  autism  precision  prediction errors  predictive coding Index. décimale : PER Périodiques Résumé : Bayesian models of autism suggest that alterations in context-sensitive prediction error weighting may underpin sensory perceptual alterations, such as hypersensitivities. We used an auditory oddball paradigm with pure tones arising from high or low uncertainty contexts to determine whether autistic individuals display differences in context adjustment relative to neurotypicals. We did not find group differences in early prediction error responses indexed by mismatch negativity. A dimensional approach revealed a positive correlation between context-dependent prediction errors and subjective reports of auditory sensitivities, but not with autistic traits. These findings suggest that autism studies may benefit from accounting for sensory sensitivities in group comparisons. LAY SUMMARY: We aimed to understand if autistic and non-autistic groups showed differences in their electrical brain activity measured by electroencephalography (EEG) when listening to surprising tones infrequently embedded in a statistical pattern. We found no differences between the autistic and the non-autistic group in their EEG response to the surprising sound even if the pattern switched, indicating their ability to learn a pattern. We did find that, as subjective sensory sensitivities (but not autistic traits) increased, there were increasingly large differences between the EEG responses to surprising tones that were embedded in the different statistical patterns of tones. These findings show that perceptual alterations may be a function of sensory sensitivities, but not necessarily autistic traits. We suggest that future EEG studies in autism may benefit from accounting for sensory sensitivities. En ligne : http://dx.doi.org/10.1002/aur.2759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder / Mairin COTTER in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Mairin COTTER, Auteur ; Seydanur REISLI, Auteur ; Ana Alves FRANCISCO, Auteur ; Kathryn-Mary WAKIM, Auteur ; Leona OAKES, Auteur ; Michael J. CROSSE, Auteur ; John J. FOXE, Auteur ; Sophie MOLHOLM, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Autism Spectrum Disorder/complications  Evoked Potentials/physiology  Auditory Perception/physiology  Magnetoencephalography  Adaptation, Psychological  Adaptive behavior  Auditory processing  Autism Spectrum Disorder  Electroencephalography  Event related potentials  Lateralization Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood. METHODS: We sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6-17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132). RESULTS: Statistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain. CONCLUSIONS: These results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism. En ligne : https://dx.doi.org/10.1186/s11689-023-09480-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder [texte imprimé] / Mairin COTTER, Auteur ; Seydanur REISLI, Auteur ; Ana Alves FRANCISCO, Auteur ; Kathryn-Mary WAKIM, Auteur ; Leona OAKES, Auteur ; Michael J. CROSSE, Auteur ; John J. FOXE, Auteur ; Sophie MOLHOLM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Humans  Child  Autism Spectrum Disorder/complications  Evoked Potentials/physiology  Auditory Perception/physiology  Magnetoencephalography  Adaptation, Psychological  Adaptive behavior  Auditory processing  Autism Spectrum Disorder  Electroencephalography  Event related potentials  Lateralization Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood. METHODS: We sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6-17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132). RESULTS: Statistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain. CONCLUSIONS: These results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism. En ligne : https://dx.doi.org/10.1186/s11689-023-09480-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome / Tufikameni BRIMA in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome Type de document : texte imprimé Auteurs : Tufikameni BRIMA, Auteur ; Shlomit BEKER, Auteur ; Kevin D. PRINSLOO, Auteur ; John S. BUTLER, Auteur ; Aleksandra DJUKIC, Auteur ; Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Rett Syndrome/physiopathology/complications  Adolescent  Female  Evoked Potentials, Auditory/physiology  Child  Young Adult  Electroencephalography  Auditory Perception/physiology  Reproducibility of Results  Acoustic Stimulation  Male  Signal-To-Noise Ratio  Adult  Auditory Evoked Potential  AEP  Auditory discrimination  Denoising Source Separation (DSS)  Eeg  Event-related potential  ERP  Females  High-density electrical mapping  Inter-Trial Phase Coherence (ITPC)  Inter-trial variability (ITV)  Neurodevelopmental disorder  Rett Syndrome Severity Scale (RSSS)  Signal-noise ratio (SNR)  X-linked mutation  MECP2  to the results of this study. Index. décimale : PER Périodiques Résumé : BACKGROUND: In the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic efficacy in clinical trials, recordings of sensory-perceptual functioning using event-related potential (ERP) approaches have emerged as potentially powerful tools. Considerable work points to highly anomalous auditory evoked potentials (AEPs) in RTT. However, an assumption of the typical signal-averaging method used to derive these measures is "stationarity" of the underlying responses - i.e. neural responses to each input are highly stereotyped. An alternate possibility is that responses to repeated stimuli are highly variable in RTT. If so, this will significantly impact the validity of assumptions about underlying neural dysfunction, and likely lead to overestimation of underlying neuropathology. To assess this possibility, analyses at the single-trial level assessing signal-to-noise ratios (SNR), inter-trial variability (ITV) and inter-trial phase coherence (ITPC) are necessary. METHODS: AEPs were recorded to simple 100 Hz tones from 18 RTT and 27 age-matched controls (Ages: 6-22 years). We applied standard AEP averaging, as well as measures of neuronal reliability at the single-trial level (i.e. SNR, ITV, ITPC). To separate signal-carrying components from non-neural noise sources, we also applied a denoising source separation (DSS) algorithm and then repeated the reliability measures. RESULTS: Substantially increased ITV, lower SNRs, and reduced ITPC were observed in auditory responses of RTT participants, supporting a "neural unreliability" account. Application of the DSS technique made it clear that non-neural noise sources contribute to overestimation of the extent of processing deficits in RTT. Post-DSS, ITV measures were substantially reduced, so much so that pre-DSS ITV differences between RTT and TD populations were no longer detected. In the case of SNR and ITPC, DSS substantially improved these estimates in the RTT population, but robust differences between RTT and TD were still fully evident. CONCLUSIONS: To accurately represent the degree of neural dysfunction in RTT using the ERP technique, a consideration of response reliability at the single-trial level is highly advised. Non-neural sources of noise lead to overestimation of the degree of pathological processing in RTT, and denoising source separation techniques during signal processing substantially ameliorate this issue. En ligne : https://dx.doi.org/10.1186/s11689-024-09544-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome [texte imprimé] / Tufikameni BRIMA, Auteur ; Shlomit BEKER, Auteur ; Kevin D. PRINSLOO, Auteur ; John S. BUTLER, Auteur ; Aleksandra DJUKIC, Auteur ; Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Rett Syndrome/physiopathology/complications  Adolescent  Female  Evoked Potentials, Auditory/physiology  Child  Young Adult  Electroencephalography  Auditory Perception/physiology  Reproducibility of Results  Acoustic Stimulation  Male  Signal-To-Noise Ratio  Adult  Auditory Evoked Potential  AEP  Auditory discrimination  Denoising Source Separation (DSS)  Eeg  Event-related potential  ERP  Females  High-density electrical mapping  Inter-Trial Phase Coherence (ITPC)  Inter-trial variability (ITV)  Neurodevelopmental disorder  Rett Syndrome Severity Scale (RSSS)  Signal-noise ratio (SNR)  X-linked mutation  MECP2  to the results of this study. Index. décimale : PER Périodiques Résumé : BACKGROUND: In the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic efficacy in clinical trials, recordings of sensory-perceptual functioning using event-related potential (ERP) approaches have emerged as potentially powerful tools. Considerable work points to highly anomalous auditory evoked potentials (AEPs) in RTT. However, an assumption of the typical signal-averaging method used to derive these measures is "stationarity" of the underlying responses - i.e. neural responses to each input are highly stereotyped. An alternate possibility is that responses to repeated stimuli are highly variable in RTT. If so, this will significantly impact the validity of assumptions about underlying neural dysfunction, and likely lead to overestimation of underlying neuropathology. To assess this possibility, analyses at the single-trial level assessing signal-to-noise ratios (SNR), inter-trial variability (ITV) and inter-trial phase coherence (ITPC) are necessary. METHODS: AEPs were recorded to simple 100 Hz tones from 18 RTT and 27 age-matched controls (Ages: 6-22 years). We applied standard AEP averaging, as well as measures of neuronal reliability at the single-trial level (i.e. SNR, ITV, ITPC). To separate signal-carrying components from non-neural noise sources, we also applied a denoising source separation (DSS) algorithm and then repeated the reliability measures. RESULTS: Substantially increased ITV, lower SNRs, and reduced ITPC were observed in auditory responses of RTT participants, supporting a "neural unreliability" account. Application of the DSS technique made it clear that non-neural noise sources contribute to overestimation of the extent of processing deficits in RTT. Post-DSS, ITV measures were substantially reduced, so much so that pre-DSS ITV differences between RTT and TD populations were no longer detected. In the case of SNR and ITPC, DSS substantially improved these estimates in the RTT population, but robust differences between RTT and TD were still fully evident. CONCLUSIONS: To accurately represent the degree of neural dysfunction in RTT using the ERP technique, a consideration of response reliability at the single-trial level is highly advised. Non-neural sources of noise lead to overestimation of the degree of pathological processing in RTT, and denoising source separation techniques during signal processing substantially ameliorate this issue. En ligne : https://dx.doi.org/10.1186/s11689-024-09544-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Degraded inferior colliculus responses to complex sounds in prenatally exposed VPA rats / Yuko TAMAOKI in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Atypical audio-visual neural synchrony and speech processing in early autism / Xiaoyue WANG in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Correlations Between Audiovisual Temporal Processing and Sensory Responsiveness in Adolescents with Autistic Traits / Han-Yu ZHOU in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome / Melody Reese SMITH in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome / Kathryn L. MCCABE in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

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