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Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder / Kenneth D. GADOW in Journal of Autism and Developmental Disorders, 39-11 (November 2009)
[article]
Titre : Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur Année de publication : 2009 Article en page(s) : p.1542-1551 Langues : Anglais (eng) Mots-clés : Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1 Index. décimale : PER Périodiques Résumé : The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. En ligne : http://dx.doi.org/10.1007/s10803-009-0794-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849
in Journal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551[article] Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur . - 2009 . - p.1542-1551.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551
Mots-clés : Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1 Index. décimale : PER Périodiques Résumé : The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. En ligne : http://dx.doi.org/10.1007/s10803-009-0794-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849