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Parent-reported and clinician-observed autism spectrum disorder (ASD) symptoms in children with attention deficit/hyperactivity disorder (ADHD): implications for practice under DSM-5 / R. GRZADZINSKI in Molecular Autism, 7 (2016)
[article]
Titre : Parent-reported and clinician-observed autism spectrum disorder (ASD) symptoms in children with attention deficit/hyperactivity disorder (ADHD): implications for practice under DSM-5 Type de document : Texte imprimé et/ou numérique Auteurs : R. GRZADZINSKI, Auteur ; C. DICK, Auteur ; C. LORD, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : 7p. Langues : Anglais (eng) Mots-clés : Adolescent Age of Onset Attention Deficit Disorder with Hyperactivity/diagnosis Autism Spectrum Disorder/diagnosis Child Child, Preschool Diagnosis, Differential Diagnostic and Statistical Manual of Mental Disorders Facial Expression Female Fixation, Ocular Humans Interview, Psychological Male Observer Variation Parents/psychology Psychiatry Psychological Tests Psychology Severity of Illness Index Social Behavior Symptom Assessment Attention Deficit/Hyperactivity Disorder (ADHD) Autism Autism Diagnostic Interview-Revised (ADI-R) Autism Diagnostic Observation Schedule (ADOS) Autism Spectrum Disorder (ASD) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with attention deficit/hyperactivity disorder (ADHD) often present with social difficulties, though the extent to which these clearly overlap with symptoms of autism spectrum disorder (ASD) is not well understood. METHODS: We explored parent-reported and directly-observed ASD symptoms on the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) in children referred to ASD-specialty clinics who received diagnoses of either ADHD (n = 48) or ASD (n = 164). RESULTS: Of the ADHD sample, 21 % met ASD cut-offs on the ADOS and 30 % met ASD cut-offs on all domains of the ADI-R. Four social communication ADOS items (Quality of Social Overtures, Unusual Eye Contact, Facial Expressions Directed to Examiner, and Amount of Reciprocal Social Communication) adequately differentiated the groups while none of the items on the ADI-R met the criteria for adequate discrimination. CONCLUSIONS: Results of this work highlight the challenges that clinicians and researchers face when distinguishing ASD from other disorders in verbally fluent, school-age children. En ligne : http://dx.doi.org/10.1186/s13229-016-0072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 7p.[article] Parent-reported and clinician-observed autism spectrum disorder (ASD) symptoms in children with attention deficit/hyperactivity disorder (ADHD): implications for practice under DSM-5 [Texte imprimé et/ou numérique] / R. GRZADZINSKI, Auteur ; C. DICK, Auteur ; C. LORD, Auteur ; Somer L. BISHOP, Auteur . - 7p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 7p.
Mots-clés : Adolescent Age of Onset Attention Deficit Disorder with Hyperactivity/diagnosis Autism Spectrum Disorder/diagnosis Child Child, Preschool Diagnosis, Differential Diagnostic and Statistical Manual of Mental Disorders Facial Expression Female Fixation, Ocular Humans Interview, Psychological Male Observer Variation Parents/psychology Psychiatry Psychological Tests Psychology Severity of Illness Index Social Behavior Symptom Assessment Attention Deficit/Hyperactivity Disorder (ADHD) Autism Autism Diagnostic Interview-Revised (ADI-R) Autism Diagnostic Observation Schedule (ADOS) Autism Spectrum Disorder (ASD) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with attention deficit/hyperactivity disorder (ADHD) often present with social difficulties, though the extent to which these clearly overlap with symptoms of autism spectrum disorder (ASD) is not well understood. METHODS: We explored parent-reported and directly-observed ASD symptoms on the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) in children referred to ASD-specialty clinics who received diagnoses of either ADHD (n = 48) or ASD (n = 164). RESULTS: Of the ADHD sample, 21 % met ASD cut-offs on the ADOS and 30 % met ASD cut-offs on all domains of the ADI-R. Four social communication ADOS items (Quality of Social Overtures, Unusual Eye Contact, Facial Expressions Directed to Examiner, and Amount of Reciprocal Social Communication) adequately differentiated the groups while none of the items on the ADI-R met the criteria for adequate discrimination. CONCLUSIONS: Results of this work highlight the challenges that clinicians and researchers face when distinguishing ASD from other disorders in verbally fluent, school-age children. En ligne : http://dx.doi.org/10.1186/s13229-016-0072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Delineating the autistic phenotype in children with neurofibromatosis type 1 / A. K. CHISHOLM in Molecular Autism, 13 (2022)
[article]
Titre : Delineating the autistic phenotype in children with neurofibromatosis type 1 Type de document : Texte imprimé et/ou numérique Auteurs : A. K. CHISHOLM, Auteur ; K. M. HAEBICH, Auteur ; N. A. PRIDE, Auteur ; K. S. WALSH, Auteur ; F. LAMI, Auteur ; A. URE, Auteur ; T. MALOOF, Auteur ; Amanda BRIGNELL, Auteur ; M. ROUEL, Auteur ; Y. GRANADER, Auteur ; A. MAIER, Auteur ; B. BARTON, Auteur ; H. DARKE, Auteur ; G. DABSCHECK, Auteur ; V. A. ANDERSON, Auteur ; K. WILLIAMS, Auteur ; K. N. NORTH, Auteur ; J. M. PAYNE, Auteur Article en page(s) : 3p. Langues : Anglais (eng) Mots-clés : Autism Autism Diagnostic Interview-Revised (ADI-R) Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Autistic behaviours Neurofibromatosis type 1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Existing research has demonstrated elevated autistic behaviours in children with neurofibromatosis type 1 (NF1), but the autistic phenotype and its relationship to other neurodevelopmental manifestations of NF1 remains unclear. To address this gap, we performed detailed characterisation of autistic behaviours in children with NF1 and investigated their association with other common NF1 child characteristics. METHODS: Participants were drawn from a larger cross-sectional study examining autism in children with NF1. The population analysed in this study scored above threshold on the Social Responsiveness Scale-Second Edition (T-score???60; 51% larger cohort) and completed the Autism Diagnostic Interview-Revised (ADI-R) and/or the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). All participants underwent evaluation of their intellectual function, and behavioural data were collected via parent questionnaires. RESULTS: The study cohort comprised 68 children (3-15 years). Sixty-three per cent met the ADOS-2 'autism spectrum' cut-off, and 34% exceeded the more stringent threshold for 'autistic disorder' on the ADI-R. Social communication symptoms were common and wide-ranging, while restricted and repetitive behaviours (RRBs) were most commonly characterised by 'insistence on sameness' (IS) behaviours such as circumscribed interests and difficulties with minor changes. Autistic behaviours were weakly correlated with hyperactive/impulsive attention deficit hyperactivity disorder (ADHD) symptoms but not with inattentive ADHD or other behavioural characteristics. Language and verbal IQ were weakly related to social communication behaviours but not to RRBs. LIMITATIONS: Lack of genetic validation of NF1, no clinical diagnosis of autism, and a retrospective assessment of autistic behaviours in early childhood. CONCLUSIONS: Findings provide strong support for elevated autistic behaviours in children with NF1. While these behaviours were relatively independent of other NF1 comorbidities, the importance of taking broader child characteristics into consideration when interpreting data from autism-specific measures in this population is highlighted. Social communication deficits appear similar to those observed in idiopathic autism and are coupled with a unique RRB profile comprising prominent IS behaviours. This autistic phenotype and its relationship to common NF1 comorbidities such as anxiety and executive dysfunction will be important to examine in future research. Current findings have important implications for the early identification of autism in NF1 and clinical management. En ligne : http://dx.doi.org/10.1186/s13229-021-00481-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 13 (2022) . - 3p.[article] Delineating the autistic phenotype in children with neurofibromatosis type 1 [Texte imprimé et/ou numérique] / A. K. CHISHOLM, Auteur ; K. M. HAEBICH, Auteur ; N. A. PRIDE, Auteur ; K. S. WALSH, Auteur ; F. LAMI, Auteur ; A. URE, Auteur ; T. MALOOF, Auteur ; Amanda BRIGNELL, Auteur ; M. ROUEL, Auteur ; Y. GRANADER, Auteur ; A. MAIER, Auteur ; B. BARTON, Auteur ; H. DARKE, Auteur ; G. DABSCHECK, Auteur ; V. A. ANDERSON, Auteur ; K. WILLIAMS, Auteur ; K. N. NORTH, Auteur ; J. M. PAYNE, Auteur . - 3p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 3p.
Mots-clés : Autism Autism Diagnostic Interview-Revised (ADI-R) Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Autistic behaviours Neurofibromatosis type 1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Existing research has demonstrated elevated autistic behaviours in children with neurofibromatosis type 1 (NF1), but the autistic phenotype and its relationship to other neurodevelopmental manifestations of NF1 remains unclear. To address this gap, we performed detailed characterisation of autistic behaviours in children with NF1 and investigated their association with other common NF1 child characteristics. METHODS: Participants were drawn from a larger cross-sectional study examining autism in children with NF1. The population analysed in this study scored above threshold on the Social Responsiveness Scale-Second Edition (T-score???60; 51% larger cohort) and completed the Autism Diagnostic Interview-Revised (ADI-R) and/or the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). All participants underwent evaluation of their intellectual function, and behavioural data were collected via parent questionnaires. RESULTS: The study cohort comprised 68 children (3-15 years). Sixty-three per cent met the ADOS-2 'autism spectrum' cut-off, and 34% exceeded the more stringent threshold for 'autistic disorder' on the ADI-R. Social communication symptoms were common and wide-ranging, while restricted and repetitive behaviours (RRBs) were most commonly characterised by 'insistence on sameness' (IS) behaviours such as circumscribed interests and difficulties with minor changes. Autistic behaviours were weakly correlated with hyperactive/impulsive attention deficit hyperactivity disorder (ADHD) symptoms but not with inattentive ADHD or other behavioural characteristics. Language and verbal IQ were weakly related to social communication behaviours but not to RRBs. LIMITATIONS: Lack of genetic validation of NF1, no clinical diagnosis of autism, and a retrospective assessment of autistic behaviours in early childhood. CONCLUSIONS: Findings provide strong support for elevated autistic behaviours in children with NF1. While these behaviours were relatively independent of other NF1 comorbidities, the importance of taking broader child characteristics into consideration when interpreting data from autism-specific measures in this population is highlighted. Social communication deficits appear similar to those observed in idiopathic autism and are coupled with a unique RRB profile comprising prominent IS behaviours. This autistic phenotype and its relationship to common NF1 comorbidities such as anxiety and executive dysfunction will be important to examine in future research. Current findings have important implications for the early identification of autism in NF1 and clinical management. En ligne : http://dx.doi.org/10.1186/s13229-021-00481-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders / Katherine GOTHAM in Autism Research, 6-1 (February 2013)
[article]
Titre : Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Katherine GOTHAM, Auteur ; Somer L. BISHOP, Auteur ; Vanessa HUS, Auteur ; Marisela HUERTA, Auteur ; Sabata LUND, Auteur ; Andreas BUJA, Auteur ; Abba KRIEGER, Auteur ; Catherine LORD, Auteur Année de publication : 2013 Article en page(s) : p.33-41 Langues : Anglais (eng) Mots-clés : autism spectrum disorders anxiety insistence on sameness Simons Simplex Collection Child Behavior Checklist 6–18 (CBCL) Autism Diagnostic Interview-Revised (ADI-R) Index. décimale : PER Périodiques Résumé : Elevated anxiety symptoms are one of the most common forms of psychopathology to co-occur with autism spectrum disorders (ASDs). The purpose of this study was to explore the association between anxiety and ASD symptoms, particularly the degree to which the relationship is explained by insistence on sameness (IS) behaviors and/or cognitive ability. The sample included 1429 individuals aged 5:8–18:0 years who participated in the Simons Simplex Collection, a genetic consortium study of ASD. Child Behavior Checklist Anxiety Problems T-scores and Autism Diagnostic Interview-Revised “IS“ item raw totals were treated as both categorical and continuous measures of anxiety and IS, respectively. Chronological age, verbal intelligence quotient (IQ), and a variety of ASD phenotype-related and other behavioral variables were assessed for potential association with anxiety and IS. Anxiety and IS continuous variables were minimally, although significantly, associated with each other and with chronological age and verbal IQ. Neither anxiety nor IS was associated with other core autism diagnostic scores. Anxiety was associated with a variety of other psychiatric and behavioral symptoms in ASD, including irritability, attention problems, and aggression, while IS was not. Anxiety and IS appear to function as distinct constructs, each with a wide range of expression in children with ASD across age and IQ levels. Thus, both variables could be of use in ASD behavioral research or in dimensional approaches to genetic exploration. Unlike IS, however, anxiety is related to non-ASD-specific behavioral symptoms. En ligne : http://dx.doi.org/10.1002/aur.1263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Autism Research > 6-1 (February 2013) . - p.33-41[article] Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Katherine GOTHAM, Auteur ; Somer L. BISHOP, Auteur ; Vanessa HUS, Auteur ; Marisela HUERTA, Auteur ; Sabata LUND, Auteur ; Andreas BUJA, Auteur ; Abba KRIEGER, Auteur ; Catherine LORD, Auteur . - 2013 . - p.33-41.
Langues : Anglais (eng)
in Autism Research > 6-1 (February 2013) . - p.33-41
Mots-clés : autism spectrum disorders anxiety insistence on sameness Simons Simplex Collection Child Behavior Checklist 6–18 (CBCL) Autism Diagnostic Interview-Revised (ADI-R) Index. décimale : PER Périodiques Résumé : Elevated anxiety symptoms are one of the most common forms of psychopathology to co-occur with autism spectrum disorders (ASDs). The purpose of this study was to explore the association between anxiety and ASD symptoms, particularly the degree to which the relationship is explained by insistence on sameness (IS) behaviors and/or cognitive ability. The sample included 1429 individuals aged 5:8–18:0 years who participated in the Simons Simplex Collection, a genetic consortium study of ASD. Child Behavior Checklist Anxiety Problems T-scores and Autism Diagnostic Interview-Revised “IS“ item raw totals were treated as both categorical and continuous measures of anxiety and IS, respectively. Chronological age, verbal intelligence quotient (IQ), and a variety of ASD phenotype-related and other behavioral variables were assessed for potential association with anxiety and IS. Anxiety and IS continuous variables were minimally, although significantly, associated with each other and with chronological age and verbal IQ. Neither anxiety nor IS was associated with other core autism diagnostic scores. Anxiety was associated with a variety of other psychiatric and behavioral symptoms in ASD, including irritability, attention problems, and aggression, while IS was not. Anxiety and IS appear to function as distinct constructs, each with a wide range of expression in children with ASD across age and IQ levels. Thus, both variables could be of use in ASD behavioral research or in dimensional approaches to genetic exploration. Unlike IS, however, anxiety is related to non-ASD-specific behavioral symptoms. En ligne : http://dx.doi.org/10.1002/aur.1263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192