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2 recherche sur le mot-clé 'Autism Spectrum Disorder/blood'
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Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis / Z. ZHENG in Journal of Autism and Developmental Disorders, 51-8 (August 2021)
[article]
Titre : Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Z. ZHENG, Auteur ; P. ZHENG, Auteur ; X. ZOU, Auteur Article en page(s) : p.2569-2577 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/blood Biomarkers Child Child, Preschool Female Humans Male S100 Calcium Binding Protein beta Subunit/blood Autism spectrum disorder Blood Meta-analysis S100b Index. décimale : PER Périodiques Résumé : The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD)?=?0.97, 95% confidence interval (95% CI)?=?0.41-1.53; p?0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04710-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2569-2577[article] Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Z. ZHENG, Auteur ; P. ZHENG, Auteur ; X. ZOU, Auteur . - p.2569-2577.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2569-2577
Mots-clés : Adolescent Autism Spectrum Disorder/blood Biomarkers Child Child, Preschool Female Humans Male S100 Calcium Binding Protein beta Subunit/blood Autism spectrum disorder Blood Meta-analysis S100b Index. décimale : PER Périodiques Résumé : The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD)?=?0.97, 95% confidence interval (95% CI)?=?0.41-1.53; p?0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04710-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) / Mehmet Fatih CEYLAN in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
[article]
Titre : Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Mehmet Fatih CEYLAN, Auteur ; S. TURAL HESAPCIOGLU, Auteur ; C. P. YAVAS, Auteur ; A. SENAT, Auteur ; O. EREL, Auteur Article en page(s) : p.2511-2517 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/blood Biomarkers/blood Case-Control Studies Child Child, Preschool Humans Leukocytes, Mononuclear Male Monocytes/immunology Oxidative Stress Peroxidase/blood Serum Albumin Serum Albumin, Human Asd Autism spectrum disorder Ima Ischemia-modified albumin Lymphocytes Monocytes Myeloperoxidase Neutrophils Index. décimale : PER Périodiques Résumé : Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts. En ligne : http://dx.doi.org/10.1007/s10803-020-04740-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2511-2517[article] Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Mehmet Fatih CEYLAN, Auteur ; S. TURAL HESAPCIOGLU, Auteur ; C. P. YAVAS, Auteur ; A. SENAT, Auteur ; O. EREL, Auteur . - p.2511-2517.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2511-2517
Mots-clés : Adolescent Adult Autism Spectrum Disorder/blood Biomarkers/blood Case-Control Studies Child Child, Preschool Humans Leukocytes, Mononuclear Male Monocytes/immunology Oxidative Stress Peroxidase/blood Serum Albumin Serum Albumin, Human Asd Autism spectrum disorder Ima Ischemia-modified albumin Lymphocytes Monocytes Myeloperoxidase Neutrophils Index. décimale : PER Périodiques Résumé : Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts. En ligne : http://dx.doi.org/10.1007/s10803-020-04740-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452