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Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults / T. FUJIOKA in Molecular Autism, 7 (2016)
[article]
Titre : Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults Type de document : Texte imprimé et/ou numérique Auteurs : T. FUJIOKA, Auteur ; K. INOHARA, Auteur ; Y. OKAMOTO, Auteur ; Y. MASUYA, Auteur ; M. ISHITOBI, Auteur ; Daisuke N. SAITO, Auteur ; M. JUNG, Auteur ; Sumiyoshi ARAI, Auteur ; Y. MATSUMURA, Auteur ; T. X. FUJISAWA, Auteur ; K. NARITA, Auteur ; K. SUZUKI, Auteur ; K. J. TSUCHIYA, Auteur ; N. MORI, Auteur ; T. KATAYAMA, Auteur ; M. SATO, Auteur ; T. MUNESUE, Auteur ; H. OKAZAWA, Auteur ; A. TOMODA, Auteur ; Y. WADA, Auteur ; H. KOSAKA, Auteur Article en page(s) : 19p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Area Under Curve Autism Spectrum Disorder/diagnosis/physiopathology Case-Control Studies Discriminant Analysis Fixation, Ocular/physiology Humans Male Ocular Physiological Phenomena Photic Stimulation Psychometrics ROC Curve Social Behavior Time Factors Autism spectrum disorder Biological motion Eye-tracking Face Fixation Gaze abnormality Geometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD. METHODS: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N = 35). We compared these percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS). Further, we conducted discriminant analyses to determine if fixation times allocated to particular objects could be used to discriminate between individuals with and without ASD. RESULTS: Compared with the TD group, the ASD group showed significantly less fixation time at locations of salient social information (i.e., eyes in the movie of human faces without lip movement and people in the movie of people and geometry), while there were no significant groupwise differences in the responses to movies of human faces with lip movement or biological motion. In a within-group correlation analysis, a few of the fixation-time items correlated with SRS, although most of them did not. No items significantly correlated with SRS in both ASD and TD groups. The percentage fixation times to eyes and people, which exhibited large effect sizes for the group difference, could differentiate ASD and TD with a sensitivity of 81.0% and a specificity of 80.0%. CONCLUSIONS: These findings suggest that Gazefinder is potentially a valuable and easy-to-use tool for objectively measuring unique gaze patterns and discriminating between ASD and TD in male adolescents and adults. En ligne : http://dx.doi.org/10.1186/s13229-016-0083-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 19p.[article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults [Texte imprimé et/ou numérique] / T. FUJIOKA, Auteur ; K. INOHARA, Auteur ; Y. OKAMOTO, Auteur ; Y. MASUYA, Auteur ; M. ISHITOBI, Auteur ; Daisuke N. SAITO, Auteur ; M. JUNG, Auteur ; Sumiyoshi ARAI, Auteur ; Y. MATSUMURA, Auteur ; T. X. FUJISAWA, Auteur ; K. NARITA, Auteur ; K. SUZUKI, Auteur ; K. J. TSUCHIYA, Auteur ; N. MORI, Auteur ; T. KATAYAMA, Auteur ; M. SATO, Auteur ; T. MUNESUE, Auteur ; H. OKAZAWA, Auteur ; A. TOMODA, Auteur ; Y. WADA, Auteur ; H. KOSAKA, Auteur . - 19p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 19p.
Mots-clés : Adolescent Adult Area Under Curve Autism Spectrum Disorder/diagnosis/physiopathology Case-Control Studies Discriminant Analysis Fixation, Ocular/physiology Humans Male Ocular Physiological Phenomena Photic Stimulation Psychometrics ROC Curve Social Behavior Time Factors Autism spectrum disorder Biological motion Eye-tracking Face Fixation Gaze abnormality Geometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD. METHODS: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N = 35). We compared these percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS). Further, we conducted discriminant analyses to determine if fixation times allocated to particular objects could be used to discriminate between individuals with and without ASD. RESULTS: Compared with the TD group, the ASD group showed significantly less fixation time at locations of salient social information (i.e., eyes in the movie of human faces without lip movement and people in the movie of people and geometry), while there were no significant groupwise differences in the responses to movies of human faces with lip movement or biological motion. In a within-group correlation analysis, a few of the fixation-time items correlated with SRS, although most of them did not. No items significantly correlated with SRS in both ASD and TD groups. The percentage fixation times to eyes and people, which exhibited large effect sizes for the group difference, could differentiate ASD and TD with a sensitivity of 81.0% and a specificity of 80.0%. CONCLUSIONS: These findings suggest that Gazefinder is potentially a valuable and easy-to-use tool for objectively measuring unique gaze patterns and discriminating between ASD and TD in male adolescents and adults. En ligne : http://dx.doi.org/10.1186/s13229-016-0083-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Short report: relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents / M. ULJAREVIC in Molecular Autism, 7 (2016)
[article]
Titre : Short report: relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents Type de document : Texte imprimé et/ou numérique Auteurs : M. ULJAREVIC, Auteur ; D. W. EVANS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : 29p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/diagnosis/physiopathology Child Child Behavior/physiology Child, Preschool Female Humans Male Middle Aged Parents/psychology Phenotype Stereotyped Behavior Autism Broader Autism Phenotype Parents Repetitive behaviours Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviours (RRBs) constitute a core symptom domain of autism spectrum disorder (ASD). However, the nature of RRBs in the context of the Broader Autism Phenotype (BAP) is not well understood. In particular, the relationship between RRBs in ASD probands and their parents remains largely unexplored. The current study explored the link between parental RRBs, measured via Interest in Patterns and Resistance to Changes subscales of the Autism Quotient and their children's RRBs, measured via Autism Diagnostic Observation Schedule RRB standardized domain score. FINDINGS: Having both parents within the top 20% of their RRB scores was associated with an increase of RRB scores for their children; however, no parent-of-origin effects were identified. Although the trend was observed for both Interest in Patterns and Resistance to Changes subscale, it was only statistically significant for Interest in Patterns. CONCLUSIONS: This paper provides significant contribution to our understanding of association between RRBs in parents and their children with ASD. Future work should also address the BAP in distinct genetic subtypes (whole chromosome aneuploidies, single gene mutations, copy number variations) of neurodevelopmental and neuropsychiatric disorders that involve RRBs. En ligne : http://dx.doi.org/10.1186/s13229-016-0091-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 29p.[article] Short report: relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents [Texte imprimé et/ou numérique] / M. ULJAREVIC, Auteur ; D. W. EVANS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - 29p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 29p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/diagnosis/physiopathology Child Child Behavior/physiology Child, Preschool Female Humans Male Middle Aged Parents/psychology Phenotype Stereotyped Behavior Autism Broader Autism Phenotype Parents Repetitive behaviours Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviours (RRBs) constitute a core symptom domain of autism spectrum disorder (ASD). However, the nature of RRBs in the context of the Broader Autism Phenotype (BAP) is not well understood. In particular, the relationship between RRBs in ASD probands and their parents remains largely unexplored. The current study explored the link between parental RRBs, measured via Interest in Patterns and Resistance to Changes subscales of the Autism Quotient and their children's RRBs, measured via Autism Diagnostic Observation Schedule RRB standardized domain score. FINDINGS: Having both parents within the top 20% of their RRB scores was associated with an increase of RRB scores for their children; however, no parent-of-origin effects were identified. Although the trend was observed for both Interest in Patterns and Resistance to Changes subscale, it was only statistically significant for Interest in Patterns. CONCLUSIONS: This paper provides significant contribution to our understanding of association between RRBs in parents and their children with ASD. Future work should also address the BAP in distinct genetic subtypes (whole chromosome aneuploidies, single gene mutations, copy number variations) of neurodevelopmental and neuropsychiatric disorders that involve RRBs. En ligne : http://dx.doi.org/10.1186/s13229-016-0091-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach / Q. WANG in Molecular Autism, 9 (2018)
[article]
Titre : Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach Type de document : Texte imprimé et/ou numérique Auteurs : Q. WANG, Auteur ; Daniel J. CAMPBELL, Auteur ; S. L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur ; F. SHIC, Auteur Article en page(s) : 25p. Langues : Anglais (eng) Mots-clés : Attention Autism Spectrum Disorder/diagnosis/physiopathology Case-Control Studies Child, Preschool Female Fixation, Ocular Humans Infant Male Social Behavior Visual Perception asd Attentional synchrony Atypicality Autism Cohesion Eye tracking Visual attention Index. décimale : PER Périodiques Résumé : Background: Multiple eye-tracking studies have highlighted the "atypical" nature of social attention in autism. However, it is unclear how "atypical" or "typical" should be quantified. Methods: We developed a method for identifying moments when members of a group looked at similar places (High-Cohesion Time Frames; HCTFs). We defined typicality as the proximity of gaze points to typically developing (TD) gaze points during TD HCTFs. Comparing toddlers with ASD (n = 112) to developmentally delayed (DD, n = 36) and TD (n = 163) toddlers during a video with Dyadic Bid, Sandwich-Making, Joint Attention, and Animated Toys conditions, we examined (a) individual typicality scores, (b) the relationship between typicality and symptom severity, and (c) HCTF distributions associated with each diagnostic group. Results: The ASD group had lower gaze typicality scores compared to the TD and DD groups in the Dyadic Bid and Sandwich-Making conditions but not during Animated Toys. The DD and TD groups did not differ in any condition. Correlational analyses indicated that higher typicality scores were associated with increased looking at pre-planned locations of the scene indexed by each experimental condition. In the ASD group, lower gaze typicality was associated with more severe autism symptoms. Examining ASD HCTFs, the gaze of toddlers with ASD was least cohesive during Dyadic Bid and most cohesive during Animated Toys. Conclusion: In contrast to non-ASD groups, toddlers with ASD show high cohesion during salient nonsocial events, suggesting that consistency in looking strategies may depend more on perceptual features. These findings are consequential for understanding individual differences in visual attention in ASD and for the design of more sensitive biomarker tasks for stratification, between-group differentiation, and measuring response to treatment. En ligne : https://dx.doi.org/10.1186/s13229-018-0211-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 25p.[article] Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach [Texte imprimé et/ou numérique] / Q. WANG, Auteur ; Daniel J. CAMPBELL, Auteur ; S. L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur ; F. SHIC, Auteur . - 25p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 25p.
Mots-clés : Attention Autism Spectrum Disorder/diagnosis/physiopathology Case-Control Studies Child, Preschool Female Fixation, Ocular Humans Infant Male Social Behavior Visual Perception asd Attentional synchrony Atypicality Autism Cohesion Eye tracking Visual attention Index. décimale : PER Périodiques Résumé : Background: Multiple eye-tracking studies have highlighted the "atypical" nature of social attention in autism. However, it is unclear how "atypical" or "typical" should be quantified. Methods: We developed a method for identifying moments when members of a group looked at similar places (High-Cohesion Time Frames; HCTFs). We defined typicality as the proximity of gaze points to typically developing (TD) gaze points during TD HCTFs. Comparing toddlers with ASD (n = 112) to developmentally delayed (DD, n = 36) and TD (n = 163) toddlers during a video with Dyadic Bid, Sandwich-Making, Joint Attention, and Animated Toys conditions, we examined (a) individual typicality scores, (b) the relationship between typicality and symptom severity, and (c) HCTF distributions associated with each diagnostic group. Results: The ASD group had lower gaze typicality scores compared to the TD and DD groups in the Dyadic Bid and Sandwich-Making conditions but not during Animated Toys. The DD and TD groups did not differ in any condition. Correlational analyses indicated that higher typicality scores were associated with increased looking at pre-planned locations of the scene indexed by each experimental condition. In the ASD group, lower gaze typicality was associated with more severe autism symptoms. Examining ASD HCTFs, the gaze of toddlers with ASD was least cohesive during Dyadic Bid and most cohesive during Animated Toys. Conclusion: In contrast to non-ASD groups, toddlers with ASD show high cohesion during salient nonsocial events, suggesting that consistency in looking strategies may depend more on perceptual features. These findings are consequential for understanding individual differences in visual attention in ASD and for the design of more sensitive biomarker tasks for stratification, between-group differentiation, and measuring response to treatment. En ligne : https://dx.doi.org/10.1186/s13229-018-0211-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Pupillary Responses Obey Emmert's Law and Co-vary with Autistic Traits / C. TORTELLI in Journal of Autism and Developmental Disorders, 51-8 (August 2021)
[article]
Titre : Pupillary Responses Obey Emmert's Law and Co-vary with Autistic Traits Type de document : Texte imprimé et/ou numérique Auteurs : C. TORTELLI, Auteur ; M. TURI, Auteur ; D. C. BURR, Auteur ; P. BINDA, Auteur Article en page(s) : p.2908-2919 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/diagnosis/physiopathology Female Humans Illusions/physiology Male Photic Stimulation Pupil/physiology Reflex, Pupillary/physiology Young Adult Autistic traits Individual differences Perceptual illusion Pupillometry Index. décimale : PER Périodiques Résumé : We measured the pupil response to a light stimulus subject to a size illusion and found that stimuli perceived as larger evoke a stronger pupillary response. The size illusion depends on combining retinal signals with contextual 3D information; contextual processing is thought to vary across individuals, being weaker in individuals with stronger autistic traits. Consistent with this theory, autistic traits correlated negatively with the magnitude of pupil modulations in our sample of neurotypical adults; however, psychophysical measurements of the illusion did not correlate with autistic traits, or with the pupil modulations. This shows that pupillometry provides an accurate objective index of complex perceptual processes, particularly useful for quantifying interindividual differences, and potentially more informative than standard psychophysical measures. En ligne : http://dx.doi.org/10.1007/s10803-020-04718-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2908-2919[article] Pupillary Responses Obey Emmert's Law and Co-vary with Autistic Traits [Texte imprimé et/ou numérique] / C. TORTELLI, Auteur ; M. TURI, Auteur ; D. C. BURR, Auteur ; P. BINDA, Auteur . - p.2908-2919.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2908-2919
Mots-clés : Adult Autism Spectrum Disorder/diagnosis/physiopathology Female Humans Illusions/physiology Male Photic Stimulation Pupil/physiology Reflex, Pupillary/physiology Young Adult Autistic traits Individual differences Perceptual illusion Pupillometry Index. décimale : PER Périodiques Résumé : We measured the pupil response to a light stimulus subject to a size illusion and found that stimuli perceived as larger evoke a stronger pupillary response. The size illusion depends on combining retinal signals with contextual 3D information; contextual processing is thought to vary across individuals, being weaker in individuals with stronger autistic traits. Consistent with this theory, autistic traits correlated negatively with the magnitude of pupil modulations in our sample of neurotypical adults; however, psychophysical measurements of the illusion did not correlate with autistic traits, or with the pupil modulations. This shows that pupillometry provides an accurate objective index of complex perceptual processes, particularly useful for quantifying interindividual differences, and potentially more informative than standard psychophysical measures. En ligne : http://dx.doi.org/10.1007/s10803-020-04718-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453