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Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? / Gao SHANE in Autism - Open Access, 5-3 ([01/06/2015])
[article]
Titre : Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? Type de document : Texte imprimé et/ou numérique Auteurs : Gao SHANE, Auteur ; Xu JUN, Auteur ; Wang JUAN, Auteur ; Wu ZEYANG, Auteur ; Yuan PING, Auteur ; Gao FENGJUAN, Auteur ; Cao LIMEI, Auteur ; Chen XU, Auteur ; Zhou FEI, Auteur ; Zhu HONGWEN, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Stem cells Mesenchymal stem cells (Mscs) Autism spectrum disorders (Asds) Neuro-immune interaction Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs), namely neurodevelopmental disorders encompassing impairments in communication, social interactions and restricted stereotypical behaviors, induces a relatively high morbidity and mortality ratio (1/166) in modern children's life. One of the serious factors accounting for ASDs is the failure of the appropriate neuro-immune interaction. Although a relationship between altered immune responses and ASDs was firstly recognized nearly 40 years ago, only recently has new evidence started to shed light on the complex multifaceted communication between neuro-immune dysfunction and behavior in ASDs. Extensive alterations in immune function have now been described in both children and adults with ASDs, including ongoing inflammation in brain specimens, elevated pro-inflammatory cytokine profiles in the Cerebro-Spinal Fluid (CSF) and blood, increased presence of brain-specific auto-antibodies and altered immune cell function. Accumulated data both from clinical and lab research proposed the essential role of neuro-immune interaction during the pathogenesis of ASDs. Stem cells, which account for normal turnover and injury repair, might do great favors on ASDs due to their ability to give rise to new functional cells as a cell replacement source, paracrine secretion as trophic and cytokine contributor, immune modulator to balance the pro-inflammation and anti-inflammation as well as the inhibitor of chronic inflammation in ASDs brain, etc. Here in this review, we focus on the current development of stem cell administration in ASDs especially on mesenchymal stem cells (MSCs), which proved to be the most plastic and efficient to interfere with ASDs neuro-immune interaction, moreover summarize the propbable mechanism and efficient therapeutic methods to treat ASDs with MSCs. En ligne : https://dx.doi.org/10.4172/2165-7890.1000151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 5-3 [01/06/2015] . - 7 p.[article] Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? [Texte imprimé et/ou numérique] / Gao SHANE, Auteur ; Xu JUN, Auteur ; Wang JUAN, Auteur ; Wu ZEYANG, Auteur ; Yuan PING, Auteur ; Gao FENGJUAN, Auteur ; Cao LIMEI, Auteur ; Chen XU, Auteur ; Zhou FEI, Auteur ; Zhu HONGWEN, Auteur . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 5-3 [01/06/2015] . - 7 p.
Mots-clés : Stem cells Mesenchymal stem cells (Mscs) Autism spectrum disorders (Asds) Neuro-immune interaction Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs), namely neurodevelopmental disorders encompassing impairments in communication, social interactions and restricted stereotypical behaviors, induces a relatively high morbidity and mortality ratio (1/166) in modern children's life. One of the serious factors accounting for ASDs is the failure of the appropriate neuro-immune interaction. Although a relationship between altered immune responses and ASDs was firstly recognized nearly 40 years ago, only recently has new evidence started to shed light on the complex multifaceted communication between neuro-immune dysfunction and behavior in ASDs. Extensive alterations in immune function have now been described in both children and adults with ASDs, including ongoing inflammation in brain specimens, elevated pro-inflammatory cytokine profiles in the Cerebro-Spinal Fluid (CSF) and blood, increased presence of brain-specific auto-antibodies and altered immune cell function. Accumulated data both from clinical and lab research proposed the essential role of neuro-immune interaction during the pathogenesis of ASDs. Stem cells, which account for normal turnover and injury repair, might do great favors on ASDs due to their ability to give rise to new functional cells as a cell replacement source, paracrine secretion as trophic and cytokine contributor, immune modulator to balance the pro-inflammation and anti-inflammation as well as the inhibitor of chronic inflammation in ASDs brain, etc. Here in this review, we focus on the current development of stem cell administration in ASDs especially on mesenchymal stem cells (MSCs), which proved to be the most plastic and efficient to interfere with ASDs neuro-immune interaction, moreover summarize the propbable mechanism and efficient therapeutic methods to treat ASDs with MSCs. En ligne : https://dx.doi.org/10.4172/2165-7890.1000151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Association of GTF2i in the Williams-Beuren Syndrome Critical Region with Autism Spectrum Disorders / Patrick MALENFANT in Journal of Autism and Developmental Disorders, 42-7 (July 2012)
[article]
Titre : Association of GTF2i in the Williams-Beuren Syndrome Critical Region with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Patrick MALENFANT, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Ying QIAO, Auteur ; Monica HRYNCHAK, Auteur ; Noémie RIENDEAU, Auteur ; M. Jeannette HILDEBRAND, Auteur ; Ira L. COHEN, Auteur ; Albert E. CHUDLEY, Auteur ; Cynthia FORSTER-GIBSON, Auteur ; Elizabeth C.R. MICKELSON, Auteur ; Evica RAJEAN-SEPAROVIC, Auteur ; M. E. Suzanne LEWIS, Auteur ; Jeanette J. A. HOLDEN, Auteur Année de publication : 2012 Article en page(s) : p.1459-1469 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorders (ASDs) Gene association GTF2i gene 7q11.23 duplication Williams-Beuren Syndrome (WBS) Index. décimale : PER Périodiques Résumé : Duplications of 7q11.23, deleted in Williams-Beuren Syndrome, have been implicated in autism spectrum disorders (ASDs). A 1.5 Mb duplication was identified in one girl with severe expressive language deficits and anxiety among 1,142 ASD individuals screened for this duplication. Family-based association studies of Tag-SNPs in three genes (STX1A , CYLN2 and GTF2i) in two multiplex autism family cohorts revealed strong association of two GTF2i SNPs and their haplotype in Cohort 1 and the combined families. The risk alleles and haplotype were associated with severe problems in social interaction and excessive repetitive behaviors. Our findings suggest the GTF2i gene is important in the etiology of autism in individuals with this duplication and in non-duplication cases with severe social interaction problems and repetitive behaviors. En ligne : http://dx.doi.org/10.1007/s10803-011-1389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1459-1469[article] Association of GTF2i in the Williams-Beuren Syndrome Critical Region with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Patrick MALENFANT, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Ying QIAO, Auteur ; Monica HRYNCHAK, Auteur ; Noémie RIENDEAU, Auteur ; M. Jeannette HILDEBRAND, Auteur ; Ira L. COHEN, Auteur ; Albert E. CHUDLEY, Auteur ; Cynthia FORSTER-GIBSON, Auteur ; Elizabeth C.R. MICKELSON, Auteur ; Evica RAJEAN-SEPAROVIC, Auteur ; M. E. Suzanne LEWIS, Auteur ; Jeanette J. A. HOLDEN, Auteur . - 2012 . - p.1459-1469.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1459-1469
Mots-clés : Autism Spectrum Disorders (ASDs) Gene association GTF2i gene 7q11.23 duplication Williams-Beuren Syndrome (WBS) Index. décimale : PER Périodiques Résumé : Duplications of 7q11.23, deleted in Williams-Beuren Syndrome, have been implicated in autism spectrum disorders (ASDs). A 1.5 Mb duplication was identified in one girl with severe expressive language deficits and anxiety among 1,142 ASD individuals screened for this duplication. Family-based association studies of Tag-SNPs in three genes (STX1A , CYLN2 and GTF2i) in two multiplex autism family cohorts revealed strong association of two GTF2i SNPs and their haplotype in Cohort 1 and the combined families. The risk alleles and haplotype were associated with severe problems in social interaction and excessive repetitive behaviors. Our findings suggest the GTF2i gene is important in the etiology of autism in individuals with this duplication and in non-duplication cases with severe social interaction problems and repetitive behaviors. En ligne : http://dx.doi.org/10.1007/s10803-011-1389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 Attentional shifts between audition and vision in Autism Spectrum Disorders / Valeria OCCELLI in Research in Autism Spectrum Disorders, 7-4 (April 2013)
[article]
Titre : Attentional shifts between audition and vision in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Valeria OCCELLI, Auteur ; Gianluca ESPOSITO, Auteur ; Paola VENUTI, Auteur ; Giuseppe Maurizio ARDUINO, Auteur ; Massimiliano ZAMPINI, Auteur Article en page(s) : p.517-525 Langues : Anglais (eng) Mots-clés : Attention Shifting Autism Spectrum Disorders (ASDs) Multisensory Auditory Visual Index. décimale : PER Périodiques Résumé : Previous evidence on neurotypical adults shows that the presentation of a stimulus allocates the attention to its modality, resulting in faster responses to a subsequent target presented in the same (vs. different) modality. People with Autism Spectrum Disorders (ASDs) often fail to detect a (visual or auditory) target in a stream of stimuli after shifting attention between modalities, possibly because they do not fully switch their attention from one modality to the other. In this study, the performance of a group of high-functioning patients with ASDs and a group of neurotypical controls was compared. Participants were asked to detect a target, auditory or visual, which was preceded, at different temporal intervals (i.e., 150, 600, 1000 ms), by an uninformative cue, either in the same or a different modality. In controls, when the target was visual, the cue modality did not affect performance. Unlike, when the target was auditory, a visual cue produced longer reaction times as compared to when it was auditory. In the ASD group, irrespectively of the modality of the cue, a slowing-down of responses to the target was observed at increasing temporal intervals. The discrepancy of performance is consistent with the ‘over-focused’ theory of sensory processing. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Research in Autism Spectrum Disorders > 7-4 (April 2013) . - p.517-525[article] Attentional shifts between audition and vision in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Valeria OCCELLI, Auteur ; Gianluca ESPOSITO, Auteur ; Paola VENUTI, Auteur ; Giuseppe Maurizio ARDUINO, Auteur ; Massimiliano ZAMPINI, Auteur . - p.517-525.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-4 (April 2013) . - p.517-525
Mots-clés : Attention Shifting Autism Spectrum Disorders (ASDs) Multisensory Auditory Visual Index. décimale : PER Périodiques Résumé : Previous evidence on neurotypical adults shows that the presentation of a stimulus allocates the attention to its modality, resulting in faster responses to a subsequent target presented in the same (vs. different) modality. People with Autism Spectrum Disorders (ASDs) often fail to detect a (visual or auditory) target in a stream of stimuli after shifting attention between modalities, possibly because they do not fully switch their attention from one modality to the other. In this study, the performance of a group of high-functioning patients with ASDs and a group of neurotypical controls was compared. Participants were asked to detect a target, auditory or visual, which was preceded, at different temporal intervals (i.e., 150, 600, 1000 ms), by an uninformative cue, either in the same or a different modality. In controls, when the target was visual, the cue modality did not affect performance. Unlike, when the target was auditory, a visual cue produced longer reaction times as compared to when it was auditory. In the ASD group, irrespectively of the modality of the cue, a slowing-down of responses to the target was observed at increasing temporal intervals. The discrepancy of performance is consistent with the ‘over-focused’ theory of sensory processing. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 Support for a Dimensional View of Autism Spectrum Disorders in Toddlers / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 42-2 (February 2012)
[article]
Titre : Support for a Dimensional View of Autism Spectrum Disorders in Toddlers Type de document : Texte imprimé et/ou numérique Auteurs : Lisa D. WIGGINS, Auteur ; Diana L. ROBINS, Auteur ; Lauren B. ADAMSON, Auteur ; Roger BAKEMAN, Auteur ; Christopher C. HENRICH, Auteur Année de publication : 2012 Article en page(s) : p.191-200 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASDs) Early identification Early diagnosis Cluster analysis Index. décimale : PER Périodiques Résumé : We examined whether clinically distinct subgroups can be derived from a sample of toddlers (n = 186) who failed the Modified Checklist for Autism in Toddlers, received a comprehensive clinical evaluation, and were diagnosed with an autism spectrum disorder (ASD). Three subgroups emerged from cluster analysis distinguished by (a) social, communication, and intellectual skills and (b) the rate and intensity of repetitive behaviors and abnormal sensory response. Preoccupations, compulsions, and rituals did not distinguish resultant subgroups. These results support a dimensional diagnostic view of ASDs in toddlers since subgroup differences were based on symptom severity rather than different symptom profiles. Results also identify specific types and levels of behavioral deficit relevant to toddler populations. Implications for early diagnosis are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1230-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.191-200[article] Support for a Dimensional View of Autism Spectrum Disorders in Toddlers [Texte imprimé et/ou numérique] / Lisa D. WIGGINS, Auteur ; Diana L. ROBINS, Auteur ; Lauren B. ADAMSON, Auteur ; Roger BAKEMAN, Auteur ; Christopher C. HENRICH, Auteur . - 2012 . - p.191-200.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.191-200
Mots-clés : Autism spectrum disorders (ASDs) Early identification Early diagnosis Cluster analysis Index. décimale : PER Périodiques Résumé : We examined whether clinically distinct subgroups can be derived from a sample of toddlers (n = 186) who failed the Modified Checklist for Autism in Toddlers, received a comprehensive clinical evaluation, and were diagnosed with an autism spectrum disorder (ASD). Three subgroups emerged from cluster analysis distinguished by (a) social, communication, and intellectual skills and (b) the rate and intensity of repetitive behaviors and abnormal sensory response. Preoccupations, compulsions, and rituals did not distinguish resultant subgroups. These results support a dimensional diagnostic view of ASDs in toddlers since subgroup differences were based on symptom severity rather than different symptom profiles. Results also identify specific types and levels of behavioral deficit relevant to toddler populations. Implications for early diagnosis are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1230-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Caring for a Child with Autism Spectrum Disorder and Parents’ Quality of Life: Application of the CarerQol / Renske HOEFMAN in Journal of Autism and Developmental Disorders, 44-8 (August 2014)
[article]
Titre : Caring for a Child with Autism Spectrum Disorder and Parents’ Quality of Life: Application of the CarerQol Type de document : Texte imprimé et/ou numérique Auteurs : Renske HOEFMAN, Auteur ; Nalin PAYAKACHAT, Auteur ; Job VAN EXEL, Auteur ; Karen A. KUHLTHAU, Auteur ; Erica KOVACS, Auteur ; Jeffrey PYNE, Auteur ; J. Mick TILFORD, Auteur Article en page(s) : p.1933-1945 Langues : Anglais (eng) Mots-clés : Family caregiving Subjective burden Autism spectrum disorders (ASDs) Quality of life CarerQol Construct validation Index. décimale : PER Périodiques Résumé : This study describes the impact of caregiving on parents of children with autism spectrum disorders (ASDs). Secondly, we investigate construct validation of the care-related quality of life instrument (CarerQol) measuring impact of caregiving. Primary caregivers of children with ASDs were included. Many parents experienced considerable problems combining daily activities with care, had financial problems or suffered from depressive mood. Validity tests showed that a higher impact of caring on the CarerQol was positively associated with higher subjective burden and lower family quality of life. Most of the associations between CarerQol scores and background characteristics confirmed previous research. The CarerQol validly measures the impact of caregiving for children with ASDs on caregivers in our sample. The CarerQol may therefore be useful for including parent outcomes in research on ASDs. En ligne : http://dx.doi.org/10.1007/s10803-014-2066-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236
in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1933-1945[article] Caring for a Child with Autism Spectrum Disorder and Parents’ Quality of Life: Application of the CarerQol [Texte imprimé et/ou numérique] / Renske HOEFMAN, Auteur ; Nalin PAYAKACHAT, Auteur ; Job VAN EXEL, Auteur ; Karen A. KUHLTHAU, Auteur ; Erica KOVACS, Auteur ; Jeffrey PYNE, Auteur ; J. Mick TILFORD, Auteur . - p.1933-1945.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1933-1945
Mots-clés : Family caregiving Subjective burden Autism spectrum disorders (ASDs) Quality of life CarerQol Construct validation Index. décimale : PER Périodiques Résumé : This study describes the impact of caregiving on parents of children with autism spectrum disorders (ASDs). Secondly, we investigate construct validation of the care-related quality of life instrument (CarerQol) measuring impact of caregiving. Primary caregivers of children with ASDs were included. Many parents experienced considerable problems combining daily activities with care, had financial problems or suffered from depressive mood. Validity tests showed that a higher impact of caring on the CarerQol was positively associated with higher subjective burden and lower family quality of life. Most of the associations between CarerQol scores and background characteristics confirmed previous research. The CarerQol validly measures the impact of caregiving for children with ASDs on caregivers in our sample. The CarerQol may therefore be useful for including parent outcomes in research on ASDs. En ligne : http://dx.doi.org/10.1007/s10803-014-2066-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence / Viktoriya O. MANYUKHINA in Molecular Autism, 13 (2022)
PermalinkPopulation- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families / Xudong LIU in Journal of Autism and Developmental Disorders, 41-7 (July 2011)
PermalinkThe Expanding Role of MBD Genes in Autism: Identification of a MECP2 Duplication and Novel Alterations in MBD5, MBD6, and SETDB1 / Holly N. CUKIER in Autism Research, 5-6 (December 2012)
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