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Autoantibody and autism spectrum disorder: A systematic review / Tianle ZOU in Research in Autism Spectrum Disorders, 75 (July 2020)
[article]
Titre : Autoantibody and autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Tianle ZOU, Auteur ; Jun LIU, Auteur ; Xueying ZHANG, Auteur ; Huilin TANG, Auteur ; Yiqing SONG, Auteur ; Xuejun KONG, Auteur Article en page(s) : p.101568 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Autoimmune Autoantibody Immune-mediated autism Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1.7 % of US pediatric population, with a growing prevalence world-wide. Autoimmunity is one of potential pathogenic factors for ASD, which is attracting much attention and undergoing extensive investigations. For more than a decade, many groups have been studying the association between autoantibodies and ASD. Although several narrative reviews have been published on autoantibodies and ASD, no systematic review or meta-analysis has been performed. In this study, we conducted the first systematic review and evaluated available evidence for the association between ASD and major autoantibodies to identifiable antigens, together with a broader discussion of autoantibodies with no identifiable antigens. The goal is to examine studies of pediatric subjects specifically and overall, we found that children with ASD expressed trends of higher levels of antibodies reactive to folate receptor ? autoantibody, anti-myelin basic protein antibodies, anti-myelin-associated glycoprotein antibodies, anti-ribosomal P protein antibodies, anti-endothelial cell antibodies, and anti-nuclear antibody, compared to healthy controls. However, the quality of evidence is low across the board because most studies were small and many did not include comparison controls. In addition, we were not able to perform a meta-analysis due to large between-study heterogeneity or lack of quantitative measures in most studies. Finally, we discussed future directions for the development of diagnostic guidelines and therapeutic targets for possible autoimmune-mediated ASD subtypes. En ligne : https://doi.org/10.1016/j.rasd.2020.101568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Research in Autism Spectrum Disorders > 75 (July 2020) . - p.101568[article] Autoantibody and autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Tianle ZOU, Auteur ; Jun LIU, Auteur ; Xueying ZHANG, Auteur ; Huilin TANG, Auteur ; Yiqing SONG, Auteur ; Xuejun KONG, Auteur . - p.101568.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 75 (July 2020) . - p.101568
Mots-clés : Autism spectrum disorder Autoimmune Autoantibody Immune-mediated autism Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1.7 % of US pediatric population, with a growing prevalence world-wide. Autoimmunity is one of potential pathogenic factors for ASD, which is attracting much attention and undergoing extensive investigations. For more than a decade, many groups have been studying the association between autoantibodies and ASD. Although several narrative reviews have been published on autoantibodies and ASD, no systematic review or meta-analysis has been performed. In this study, we conducted the first systematic review and evaluated available evidence for the association between ASD and major autoantibodies to identifiable antigens, together with a broader discussion of autoantibodies with no identifiable antigens. The goal is to examine studies of pediatric subjects specifically and overall, we found that children with ASD expressed trends of higher levels of antibodies reactive to folate receptor ? autoantibody, anti-myelin basic protein antibodies, anti-myelin-associated glycoprotein antibodies, anti-ribosomal P protein antibodies, anti-endothelial cell antibodies, and anti-nuclear antibody, compared to healthy controls. However, the quality of evidence is low across the board because most studies were small and many did not include comparison controls. In addition, we were not able to perform a meta-analysis due to large between-study heterogeneity or lack of quantitative measures in most studies. Finally, we discussed future directions for the development of diagnostic guidelines and therapeutic targets for possible autoimmune-mediated ASD subtypes. En ligne : https://doi.org/10.1016/j.rasd.2020.101568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development / Lisa A. CROEN in Autism Research, 12-1 (January 2019)
[article]
Titre : Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; D. FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; A. B. SINGER, Auteur ; O. ZERBO, Auteur Article en page(s) : p.123-135 Langues : Anglais (eng) Mots-clés : allergy asthma autism autoimmune pregnancy prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.123-135[article] Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; D. FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; A. B. SINGER, Auteur ; O. ZERBO, Auteur . - p.123-135.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.123-135
Mots-clés : allergy asthma autism autoimmune pregnancy prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 Male Gender Bias in Autism and Pediatric Autoimmunity / Kevin G. BECKER in Autism Research, 5-2 (April 2012)
[article]
Titre : Male Gender Bias in Autism and Pediatric Autoimmunity Type de document : Texte imprimé et/ou numérique Auteurs : Kevin G. BECKER, Auteur Année de publication : 2012 Article en page(s) : p.77-83 Langues : Anglais (eng) Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.77-83[article] Male Gender Bias in Autism and Pediatric Autoimmunity [Texte imprimé et/ou numérique] / Kevin G. BECKER, Auteur . - 2012 . - p.77-83.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.77-83
Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Co-occurrence of Autism and Asthma in a Nationally-Representative Sample of Children in the United States / Stanley KOTEY in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
[article]
Titre : Co-occurrence of Autism and Asthma in a Nationally-Representative Sample of Children in the United States Type de document : Texte imprimé et/ou numérique Auteurs : Stanley KOTEY, Auteur ; Karen ERTEL, Auteur ; Brian WHITCOMB, Auteur Article en page(s) : p.3083-3088 Langues : Anglais (eng) Mots-clés : Autism Asthma Autoimmune Screening Allergy Index. décimale : PER Périodiques Résumé : Few large epidemiological studies have examined the co-occurrence of autism and asthma. We performed a cross-sectional study to examine this association using the 2007 National Survey of Children’s Health dataset (n = 77,951). We controlled for confounders and tested for autism-secondhand smoke interaction. Prevalence of asthma and autism were 14.5 % (n = 11,335) and 1.81 % (n = 1,412) respectively. Unadjusted odds ratio (OR) for asthma among autistic children was 1.35 (95 % CI 1.18–1.55). Adjusting for covariates (age, gender, body mass index, race, brain injury, secondhand smoke and socio-economic status) attenuated the OR to 1.19 (95 % CI 1.03–1.36). Autism-secondhand smoke interaction was insignificant (p = 0.38). Asthma is approximately 35 % more common in autistic children; screening may be an efficient approach to reduce risk of morbidity due to asthma. En ligne : http://dx.doi.org/10.1007/s10803-014-2174-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3083-3088[article] Co-occurrence of Autism and Asthma in a Nationally-Representative Sample of Children in the United States [Texte imprimé et/ou numérique] / Stanley KOTEY, Auteur ; Karen ERTEL, Auteur ; Brian WHITCOMB, Auteur . - p.3083-3088.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3083-3088
Mots-clés : Autism Asthma Autoimmune Screening Allergy Index. décimale : PER Périodiques Résumé : Few large epidemiological studies have examined the co-occurrence of autism and asthma. We performed a cross-sectional study to examine this association using the 2007 National Survey of Children’s Health dataset (n = 77,951). We controlled for confounders and tested for autism-secondhand smoke interaction. Prevalence of asthma and autism were 14.5 % (n = 11,335) and 1.81 % (n = 1,412) respectively. Unadjusted odds ratio (OR) for asthma among autistic children was 1.35 (95 % CI 1.18–1.55). Adjusting for covariates (age, gender, body mass index, race, brain injury, secondhand smoke and socio-economic status) attenuated the OR to 1.19 (95 % CI 1.03–1.36). Autism-secondhand smoke interaction was insignificant (p = 0.38). Asthma is approximately 35 % more common in autistic children; screening may be an efficient approach to reduce risk of morbidity due to asthma. En ligne : http://dx.doi.org/10.1007/s10803-014-2174-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243