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Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) / Mehmet Fatih CEYLAN in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
[article]
Titre : Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Mehmet Fatih CEYLAN, Auteur ; S. TURAL HESAPCIOGLU, Auteur ; C. P. YAVAS, Auteur ; A. SENAT, Auteur ; O. EREL, Auteur Article en page(s) : p.2511-2517 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/blood Biomarkers/blood Case-Control Studies Child Child, Preschool Humans Leukocytes, Mononuclear Male Monocytes/immunology Oxidative Stress Peroxidase/blood Serum Albumin Serum Albumin, Human Asd Autism spectrum disorder Ima Ischemia-modified albumin Lymphocytes Monocytes Myeloperoxidase Neutrophils Index. décimale : PER Périodiques Résumé : Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts. En ligne : http://dx.doi.org/10.1007/s10803-020-04740-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2511-2517[article] Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Mehmet Fatih CEYLAN, Auteur ; S. TURAL HESAPCIOGLU, Auteur ; C. P. YAVAS, Auteur ; A. SENAT, Auteur ; O. EREL, Auteur . - p.2511-2517.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2511-2517
Mots-clés : Adolescent Adult Autism Spectrum Disorder/blood Biomarkers/blood Case-Control Studies Child Child, Preschool Humans Leukocytes, Mononuclear Male Monocytes/immunology Oxidative Stress Peroxidase/blood Serum Albumin Serum Albumin, Human Asd Autism spectrum disorder Ima Ischemia-modified albumin Lymphocytes Monocytes Myeloperoxidase Neutrophils Index. décimale : PER Périodiques Résumé : Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts. En ligne : http://dx.doi.org/10.1007/s10803-020-04740-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California / K. LYALL in Molecular Autism, 12 (2021)
[article]
Titre : A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California Type de document : Texte imprimé et/ou numérique Auteurs : K. LYALL, Auteur ; Jennifer L. AMES, Auteur ; M. PEARL, Auteur ; M. TRAGLIA, Auteur ; L. A. WEISS, Auteur ; G. C. WINDHAM, Auteur ; M. KHARRAZI, Auteur ; C. K. YOSHIDA, Auteur ; R. YOLKEN, Auteur ; Heather E. VOLK, Auteur ; Paul ASHWOOD, Auteur ; J. VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : 24 p. Langues : Anglais (eng) Mots-clés : Adult Autistic Disorder/blood/epidemiology/immunology Biomarkers/blood California/epidemiology Case-Control Studies Child Cytokines/immunology Endocrine Disruptors Environmental Exposure Environmental Pollutants Female Humans Male Pregnancy/immunology Thyroid Hormones/blood Vitamin D/blood Young Adult Autism Early Markers for Autism Immune response Risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: The Early Markers for Autism (EMA) study is a population-based case-control study designed to learn more about early biologic processes involved in ASD. METHODS: Participants were drawn from Southern California births from 2000 to 2003 with archived prenatal and neonatal screening specimens. Across two phases, children with ASD (n?=?629) and intellectual disability without ASD (ID, n?=?230) were ascertained from the California Department of Developmental Services (DDS), with diagnoses confirmed according to DSM-IV-TR criteria based on expert clinical review of abstracted records. General population controls (GP, n?=?599) were randomly sampled from birth certificate files and matched to ASD cases by sex, birth month and year after excluding individuals with DDS records. EMA has published over 20 papers examining immune markers, endogenous hormones, environmental chemicals, and genetic factors in association with ASD and ID. This review summarizes the results across these studies, as well as the EMA study design and future directions. RESULTS: EMA enabled several key contributions to the literature, including the examination of biomarker levels in biospecimens prospectively collected during critical windows of neurodevelopment. Key findings from EMA include demonstration of elevated cytokine and chemokine levels in maternal mid-pregnancy serum samples in association with ASD, as well as aberrations in other immune marker levels; suggestions of increased odds of ASD with prenatal exposure to certain endocrine disrupting chemicals, though not in mixture analyses; and demonstration of maternal and fetal genetic influence on prenatal chemical, and maternal and neonatal immune marker and vitamin D levels. We also observed an overall lack of association with ASD and measured maternal and neonatal vitamin D, mercury, and brain-derived neurotrophic factor (BDNF) levels. LIMITATIONS: Covariate and outcome data were limited to information in Vital Statistics and DDS records. As a study based in Southern California, generalizability for certain environmental exposures may be reduced. CONCLUSIONS: Results across EMA studies support the importance of the prenatal and neonatal periods in ASD etiology, and provide evidence for the role of the maternal immune response during pregnancy. Future directions for EMA, and the field of ASD in general, include interrogation of mechanistic pathways and examination of combined effects of exposures. En ligne : http://dx.doi.org/10.1186/s13229-021-00429-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 24 p.[article] A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California [Texte imprimé et/ou numérique] / K. LYALL, Auteur ; Jennifer L. AMES, Auteur ; M. PEARL, Auteur ; M. TRAGLIA, Auteur ; L. A. WEISS, Auteur ; G. C. WINDHAM, Auteur ; M. KHARRAZI, Auteur ; C. K. YOSHIDA, Auteur ; R. YOLKEN, Auteur ; Heather E. VOLK, Auteur ; Paul ASHWOOD, Auteur ; J. VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur . - 24 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 24 p.
Mots-clés : Adult Autistic Disorder/blood/epidemiology/immunology Biomarkers/blood California/epidemiology Case-Control Studies Child Cytokines/immunology Endocrine Disruptors Environmental Exposure Environmental Pollutants Female Humans Male Pregnancy/immunology Thyroid Hormones/blood Vitamin D/blood Young Adult Autism Early Markers for Autism Immune response Risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: The Early Markers for Autism (EMA) study is a population-based case-control study designed to learn more about early biologic processes involved in ASD. METHODS: Participants were drawn from Southern California births from 2000 to 2003 with archived prenatal and neonatal screening specimens. Across two phases, children with ASD (n?=?629) and intellectual disability without ASD (ID, n?=?230) were ascertained from the California Department of Developmental Services (DDS), with diagnoses confirmed according to DSM-IV-TR criteria based on expert clinical review of abstracted records. General population controls (GP, n?=?599) were randomly sampled from birth certificate files and matched to ASD cases by sex, birth month and year after excluding individuals with DDS records. EMA has published over 20 papers examining immune markers, endogenous hormones, environmental chemicals, and genetic factors in association with ASD and ID. This review summarizes the results across these studies, as well as the EMA study design and future directions. RESULTS: EMA enabled several key contributions to the literature, including the examination of biomarker levels in biospecimens prospectively collected during critical windows of neurodevelopment. Key findings from EMA include demonstration of elevated cytokine and chemokine levels in maternal mid-pregnancy serum samples in association with ASD, as well as aberrations in other immune marker levels; suggestions of increased odds of ASD with prenatal exposure to certain endocrine disrupting chemicals, though not in mixture analyses; and demonstration of maternal and fetal genetic influence on prenatal chemical, and maternal and neonatal immune marker and vitamin D levels. We also observed an overall lack of association with ASD and measured maternal and neonatal vitamin D, mercury, and brain-derived neurotrophic factor (BDNF) levels. LIMITATIONS: Covariate and outcome data were limited to information in Vital Statistics and DDS records. As a study based in Southern California, generalizability for certain environmental exposures may be reduced. CONCLUSIONS: Results across EMA studies support the importance of the prenatal and neonatal periods in ASD etiology, and provide evidence for the role of the maternal immune response during pregnancy. Future directions for EMA, and the field of ASD in general, include interrogation of mechanistic pathways and examination of combined effects of exposures. En ligne : http://dx.doi.org/10.1186/s13229-021-00429-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459