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Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis / Z. ZHENG in Journal of Autism and Developmental Disorders, 51-8 (August 2021)
[article]
Titre : Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Z. ZHENG, Auteur ; P. ZHENG, Auteur ; X. ZOU, Auteur Article en page(s) : p.2569-2577 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/blood Biomarkers Child Child, Preschool Female Humans Male S100 Calcium Binding Protein beta Subunit/blood Autism spectrum disorder Blood Meta-analysis S100b Index. décimale : PER Périodiques Résumé : The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD)?=?0.97, 95% confidence interval (95% CI)?=?0.41-1.53; p?0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04710-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2569-2577[article] Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Z. ZHENG, Auteur ; P. ZHENG, Auteur ; X. ZOU, Auteur . - p.2569-2577.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2569-2577
Mots-clés : Adolescent Autism Spectrum Disorder/blood Biomarkers Child Child, Preschool Female Humans Male S100 Calcium Binding Protein beta Subunit/blood Autism spectrum disorder Blood Meta-analysis S100b Index. décimale : PER Périodiques Résumé : The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD)?=?0.97, 95% confidence interval (95% CI)?=?0.41-1.53; p?0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04710-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies / S. JOHN in Autism, 25-8 (November 2021)
[article]
Titre : Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies Type de document : Texte imprimé et/ou numérique Auteurs : S. JOHN, Auteur ; A. V. JAEGGI, Auteur Article en page(s) : p.2152-2161 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-8 (November 2021) . - p.2152-2161[article] Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies [Texte imprimé et/ou numérique] / S. JOHN, Auteur ; A. V. JAEGGI, Auteur . - p.2152-2161.
Langues : Anglais (eng)
in Autism > 25-8 (November 2021) . - p.2152-2161
Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders / Rabindra TIROUVANZIAM in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
[article]
Titre : Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur Année de publication : 2012 Article en page(s) : p.827-836 Langues : Anglais (eng) Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836[article] Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur . - 2012 . - p.827-836.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836
Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154