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Exaggerated CpH methylation in the autism-affected brain / S. E. ELLIS in Molecular Autism, 8 (2017)
[article]
Titre : Exaggerated CpH methylation in the autism-affected brain Type de document : Texte imprimé et/ou numérique Auteurs : S. E. ELLIS, Auteur ; S. GUPTA, Auteur ; A. MOES, Auteur ; A. B. WEST, Auteur ; D. E. ARKING, Auteur Article en page(s) : 6p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/*genetics/pathology Autopsy Base Composition Brain Chemistry *DNA Methylation Epigenesis, Genetic Humans Male Sequence Analysis, DNA/*methods *Autism *Bisulfite sequencing *Brains *Methylation *Rrbs Index. décimale : PER Périodiques Résumé : BACKGROUND: The etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the role of CpG and CpH (H = A, C, or T) methylation within the autism-affected cortical brain tissue. METHODS: Reduced representation bisulfite sequencing (RRBS) was completed, and analysis was carried out in 63 post-mortem cortical brain samples (Brodmann area 19) from 29 autism-affected and 34 control individuals. Analyses to identify single sites that were differentially methylated and to identify any global methylation alterations at either CpG or CpH sites throughout the genome were carried out. RESULTS: We report that while no individual site or region of methylation was significantly associated with autism after multi-test correction, methylated CpH dinucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p < 0.05 cutoff, p = 0.002). CONCLUSIONS: These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0119-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 6p.[article] Exaggerated CpH methylation in the autism-affected brain [Texte imprimé et/ou numérique] / S. E. ELLIS, Auteur ; S. GUPTA, Auteur ; A. MOES, Auteur ; A. B. WEST, Auteur ; D. E. ARKING, Auteur . - 6p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 6p.
Mots-clés : Autistic Disorder/*genetics/pathology Autopsy Base Composition Brain Chemistry *DNA Methylation Epigenesis, Genetic Humans Male Sequence Analysis, DNA/*methods *Autism *Bisulfite sequencing *Brains *Methylation *Rrbs Index. décimale : PER Périodiques Résumé : BACKGROUND: The etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the role of CpG and CpH (H = A, C, or T) methylation within the autism-affected cortical brain tissue. METHODS: Reduced representation bisulfite sequencing (RRBS) was completed, and analysis was carried out in 63 post-mortem cortical brain samples (Brodmann area 19) from 29 autism-affected and 34 control individuals. Analyses to identify single sites that were differentially methylated and to identify any global methylation alterations at either CpG or CpH sites throughout the genome were carried out. RESULTS: We report that while no individual site or region of methylation was significantly associated with autism after multi-test correction, methylated CpH dinucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p < 0.05 cutoff, p = 0.002). CONCLUSIONS: These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0119-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)
[article]
Titre : From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition Type de document : Texte imprimé et/ou numérique Auteurs : A. M. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; D. ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; J. SUCKLING, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Amniotic Fluid/chemistry Animals Antigens, Surface/immunology Autism Spectrum Disorder/genetics/immunology/pathology Autoantibodies/analysis Body Fluids/chemistry Brain/embryology/immunology/pathology Brain Chemistry Chemokines/analysis Cytokines/analysis Female Glutamic Acid/metabolism HLA Antigens/immunology Haplorhini Humans Immunity, Maternally-Acquired Inflammation Inflammation Mediators/analysis Lipopolysaccharides/blood Maternal-Fetal Exchange Mice Nerve Tissue Proteins/immunology Neuroglia/physiology Neuroimaging Pregnancy Pregnancy Complications, Infectious/blood Prenatal Exposure Delayed Effects Signal Transduction Autism Brain NF-kappaB Index. décimale : PER Périodiques Résumé : Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1186/s13229-016-0068-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 9p.[article] From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition [Texte imprimé et/ou numérique] / A. M. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; D. ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; J. SUCKLING, Auteur ; Simon BARON-COHEN, Auteur . - 9p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 9p.