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The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients / Dario SINISCALCO in Journal of Autism and Developmental Disorders, 42-7 (July 2012)
[article]
Titre : The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur Année de publication : 2012 Article en page(s) : p.1403-1410 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Caspases Gene expression PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410[article] The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur . - 2012 . - p.1403-1410.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410
Mots-clés : Autism spectrum disorders Caspases Gene expression PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166