Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
3 recherche sur le mot-clé 'Caudate nucleus'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Altered reward system reactivity for personalized circumscribed interests in autism / G. KOHLS in Molecular Autism, 9 (2018)
[article]
Titre : Altered reward system reactivity for personalized circumscribed interests in autism Type de document : Texte imprimé et/ou numérique Auteurs : G. KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; M. G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; B. E. YERYS, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Caudate nucleus Circumscribed interests Functional magnetic resonance imaging Motivation Restricted and repetitive behaviors and interests Reward Reward system Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354
in Molecular Autism > 9 (2018) . - 9p.[article] Altered reward system reactivity for personalized circumscribed interests in autism [Texte imprimé et/ou numérique] / G. KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; M. G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; B. E. YERYS, Auteur . - 9p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 9p.
Mots-clés : Autism spectrum disorders Caudate nucleus Circumscribed interests Functional magnetic resonance imaging Motivation Restricted and repetitive behaviors and interests Reward Reward system Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study / In-Seong HWANG in Autism Research, 15-12 (December 2022)
[article]
Titre : Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study Type de document : Texte imprimé et/ou numérique Auteurs : In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur Article en page(s) : p.2238-2249 Langues : Anglais (eng) Mots-clés : Child Humans Adolescent Autism Spectrum Disorder/diagnostic imaging/pathology Body Mass Index Pediatric Obesity/complications/diagnostic imaging Magnetic Resonance Imaging/methods Brain/diagnostic imaging/pathology autism spectrum disorder caudate nucleus obesity subcortical volume ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-12 (December 2022) . - p.2238-2249[article] Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study [Texte imprimé et/ou numérique] / In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur . - p.2238-2249.
Langues : Anglais (eng)
in Autism Research > 15-12 (December 2022) . - p.2238-2249
Mots-clés : Child Humans Adolescent Autism Spectrum Disorder/diagnostic imaging/pathology Body Mass Index Pediatric Obesity/complications/diagnostic imaging Magnetic Resonance Imaging/methods Brain/diagnostic imaging/pathology autism spectrum disorder caudate nucleus obesity subcortical volume ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 8-1 (January 2014)
[article]
Titre : Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51[article] Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.44-51.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51
Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220