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Clustering of co-occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data / T. VARGASON in Autism Research, 12-8 (August 2019)
[article]
Titre : Clustering of co-occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data Type de document : Texte imprimé et/ou numérique Auteurs : T. VARGASON, Auteur ; R. E. FRYE, Auteur ; D. L. MCGUINNESS, Auteur ; J. HAHN, Auteur Article en page(s) : p.1272-1285 Langues : Anglais (eng) Mots-clés : k-means clustering autism spectrum disorder co-occurring condition comorbidity medical claims retrospective analysis Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) are frequently affected by co-occurring medical conditions (COCs), which vary in severity, age of onset, and pathophysiological characteristics. The presence of COCs contributes to significant heterogeneity in the clinical presentation of ASD between individuals and a better understanding of COCs may offer greater insight into the etiology of ASD in specific subgroups while also providing guidance for diagnostic and treatment protocols. This study retrospectively analyzed medical claims data from a private United States health plan between years 2000 and 2015 to investigate patterns of COC diagnoses in a cohort of 3,278 children with ASD throughout their first 5 years of enrollment compared to 279,693 children from the general population without ASD diagnoses (POP cohort). Three subgroups of children with ASD were identified by k-means clustering using these COC patterns. The first cluster was characterized by generally high rates of COC diagnosis and comprised 23.7% (n = 776) of the cohort. Diagnoses of developmental delays were dominant in the second cluster containing 26.5% (n = 870) of the cohort. Children in the third cluster, making up 49.8% (n = 1,632) of the cohort, had the lowest rates of COC diagnosis, which were slightly higher than rates observed in the POP cohort. A secondary analysis using these data found that gastrointestinal and immune disorders showed similar longitudinal patterns of prevalence, as did seizure and sleep disorders. These findings may help to better inform the development of diagnostic workup and treatment protocols for COCs in children with ASD. Autism Res 2019, 12: 1272-1285. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Medical conditions that co-occur with autism spectrum disorder (ASD) vary significantly from person to person. This study analyzed patterns in diagnosis of co-occurring conditions from medical claims data and observed three subtypes of children with ASD. These results may aid with screening for co-occurring conditions in children with ASD and with understanding ASD subtypes. En ligne : http://dx.doi.org/10.1002/aur.2128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Autism Research > 12-8 (August 2019) . - p.1272-1285[article] Clustering of co-occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data [Texte imprimé et/ou numérique] / T. VARGASON, Auteur ; R. E. FRYE, Auteur ; D. L. MCGUINNESS, Auteur ; J. HAHN, Auteur . - p.1272-1285.
Langues : Anglais (eng)
in Autism Research > 12-8 (August 2019) . - p.1272-1285
Mots-clés : k-means clustering autism spectrum disorder co-occurring condition comorbidity medical claims retrospective analysis Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) are frequently affected by co-occurring medical conditions (COCs), which vary in severity, age of onset, and pathophysiological characteristics. The presence of COCs contributes to significant heterogeneity in the clinical presentation of ASD between individuals and a better understanding of COCs may offer greater insight into the etiology of ASD in specific subgroups while also providing guidance for diagnostic and treatment protocols. This study retrospectively analyzed medical claims data from a private United States health plan between years 2000 and 2015 to investigate patterns of COC diagnoses in a cohort of 3,278 children with ASD throughout their first 5 years of enrollment compared to 279,693 children from the general population without ASD diagnoses (POP cohort). Three subgroups of children with ASD were identified by k-means clustering using these COC patterns. The first cluster was characterized by generally high rates of COC diagnosis and comprised 23.7% (n = 776) of the cohort. Diagnoses of developmental delays were dominant in the second cluster containing 26.5% (n = 870) of the cohort. Children in the third cluster, making up 49.8% (n = 1,632) of the cohort, had the lowest rates of COC diagnosis, which were slightly higher than rates observed in the POP cohort. A secondary analysis using these data found that gastrointestinal and immune disorders showed similar longitudinal patterns of prevalence, as did seizure and sleep disorders. These findings may help to better inform the development of diagnostic workup and treatment protocols for COCs in children with ASD. Autism Res 2019, 12: 1272-1285. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Medical conditions that co-occur with autism spectrum disorder (ASD) vary significantly from person to person. This study analyzed patterns in diagnosis of co-occurring conditions from medical claims data and observed three subtypes of children with ASD. These results may aid with screening for co-occurring conditions in children with ASD and with understanding ASD subtypes. En ligne : http://dx.doi.org/10.1002/aur.2128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Sex Differences in Co-occurring Conditions Among Autistic Children and Youth in Florida: A Retrospective Cohort Study (2012-2019) / Amber M. ANGELL in Journal of Autism and Developmental Disorders, 51-10 (October 2021)
[article]
Titre : Sex Differences in Co-occurring Conditions Among Autistic Children and Youth in Florida: A Retrospective Cohort Study (2012-2019) Type de document : Texte imprimé et/ou numérique Auteurs : Amber M. ANGELL, Auteur ; Alexis DEAVENPORT-SAMAN, Auteur ; L. YIN, Auteur ; B. ZOU, Auteur ; C. BAI, Auteur ; D. VARMA, Auteur ; O. SOLOMON, Auteur Article en page(s) : p.3759-3765 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Child, Preschool Female Florida/epidemiology Humans Infant Male Retrospective Studies Sex Characteristics Sex Factors Young Adult Autism spectrum disorder Co-occurring condition Gender Girls Healthcare claims Sex Index. décimale : PER Périodiques Résumé : Autistic children have a high prevalence of co-occurring mental health, developmental/behavioral, and medical conditions, but research on sex/gender differences has been mixed. We used Florida healthcare claims data to characterize sex differences (female/male) in co-occurring conditions among autistic children ages 1-21 (N?=?83,500). After adjusting for age, race, ethnicity, urbanicity, and insurance, autistic girls had significantly higher odds of anxiety disorders, mood disorders, intellectual disability, developmental disorders, epilepsy, metabolic disorders, gastrointestinal disorders, and sleep disorders compared to autistic boys. Autistic girls had significantly lower odds of ADHD. The findings contribute to the growing body of research on the unique healthcare needs of autistic girls. En ligne : http://dx.doi.org/10.1007/s10803-020-04841-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3759-3765[article] Sex Differences in Co-occurring Conditions Among Autistic Children and Youth in Florida: A Retrospective Cohort Study (2012-2019) [Texte imprimé et/ou numérique] / Amber M. ANGELL, Auteur ; Alexis DEAVENPORT-SAMAN, Auteur ; L. YIN, Auteur ; B. ZOU, Auteur ; C. BAI, Auteur ; D. VARMA, Auteur ; O. SOLOMON, Auteur . - p.3759-3765.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3759-3765
Mots-clés : Adolescent Adult Autism Spectrum Disorder/epidemiology Autistic Disorder/epidemiology Child Child, Preschool Female Florida/epidemiology Humans Infant Male Retrospective Studies Sex Characteristics Sex Factors Young Adult Autism spectrum disorder Co-occurring condition Gender Girls Healthcare claims Sex Index. décimale : PER Périodiques Résumé : Autistic children have a high prevalence of co-occurring mental health, developmental/behavioral, and medical conditions, but research on sex/gender differences has been mixed. We used Florida healthcare claims data to characterize sex differences (female/male) in co-occurring conditions among autistic children ages 1-21 (N?=?83,500). After adjusting for age, race, ethnicity, urbanicity, and insurance, autistic girls had significantly higher odds of anxiety disorders, mood disorders, intellectual disability, developmental disorders, epilepsy, metabolic disorders, gastrointestinal disorders, and sleep disorders compared to autistic boys. Autistic girls had significantly lower odds of ADHD. The findings contribute to the growing body of research on the unique healthcare needs of autistic girls. En ligne : http://dx.doi.org/10.1007/s10803-020-04841-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453