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Maltreatment-associated neurodevelopmental disorders: a co-twin control analysis / Lisa DINKLER in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)
[article]
Titre : Maltreatment-associated neurodevelopmental disorders: a co-twin control analysis Type de document : Texte imprimé et/ou numérique Auteurs : Lisa DINKLER, Auteur ; Sebastian LUNDSTROM, Auteur ; Ruchika GAJWANI, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Helen MINNIS, Auteur Article en page(s) : p.691-701 Langues : Anglais (eng) Mots-clés : Child maltreatment child abuse neurodevelopmental disorders behavior genetics co-twin control design Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment (CM) is strongly associated with psychiatric disorders in childhood and adulthood. Previous findings suggest that the association between CM and psychiatric disorders is partly causal and partly due to familial confounding, but few studies have investigated the mechanisms behind the association between CM and neurodevelopmental disorders (NDDs). Our objective was to determine whether maltreated children have an elevated number of NDDs and whether CM is a risk factor for an increased NDD ‘load’ and increased NDD symptoms when controlling for familial effects. Methods We used a cross-sectional sample from a population-representative Swedish twin study, comprising 8,192 nine-year-old twins born in Sweden between 1997 and 2005. CM was defined as parent-reported exposure to emotional abuse/neglect, physical neglect, physical abuse, and/or sexual abuse. Four NDDs were measured with the Autism–Tics, AD/HD, and other comorbidities inventory. Results Maltreated children had a greater mean number of NDDs than nonmaltreated children. In a co-twin control design, CM-discordant monozygotic twins did not differ significantly for their number of NDDs, suggesting that CM is not associated with an increased load of NDDs when genetic and shared environmental factors are taken into account. However, CM was associated with a small increase in symptoms of attention-deficit/hyperactivity disorder and autism spectrum disorder in CM-discordant MZ twins, although most of the covariance of CM with NDD symptoms was explained by common genetic effects. Conclusions Maltreated children are at higher risk of having multiple NDDs. Our findings are, however, not consistent with the notion that CM causes the increased NDD load in maltreated children. Maltreated children should receive a full neurodevelopmental assessment, and clinicians should be aware that children with multiple NDDs are at higher risk of maltreatment. En ligne : http://dx.doi.org/10.1111/jcpp.12682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308
in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.691-701[article] Maltreatment-associated neurodevelopmental disorders: a co-twin control analysis [Texte imprimé et/ou numérique] / Lisa DINKLER, Auteur ; Sebastian LUNDSTROM, Auteur ; Ruchika GAJWANI, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Helen MINNIS, Auteur . - p.691-701.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.691-701
Mots-clés : Child maltreatment child abuse neurodevelopmental disorders behavior genetics co-twin control design Index. décimale : PER Périodiques Résumé : Background Childhood maltreatment (CM) is strongly associated with psychiatric disorders in childhood and adulthood. Previous findings suggest that the association between CM and psychiatric disorders is partly causal and partly due to familial confounding, but few studies have investigated the mechanisms behind the association between CM and neurodevelopmental disorders (NDDs). Our objective was to determine whether maltreated children have an elevated number of NDDs and whether CM is a risk factor for an increased NDD ‘load’ and increased NDD symptoms when controlling for familial effects. Methods We used a cross-sectional sample from a population-representative Swedish twin study, comprising 8,192 nine-year-old twins born in Sweden between 1997 and 2005. CM was defined as parent-reported exposure to emotional abuse/neglect, physical neglect, physical abuse, and/or sexual abuse. Four NDDs were measured with the Autism–Tics, AD/HD, and other comorbidities inventory. Results Maltreated children had a greater mean number of NDDs than nonmaltreated children. In a co-twin control design, CM-discordant monozygotic twins did not differ significantly for their number of NDDs, suggesting that CM is not associated with an increased load of NDDs when genetic and shared environmental factors are taken into account. However, CM was associated with a small increase in symptoms of attention-deficit/hyperactivity disorder and autism spectrum disorder in CM-discordant MZ twins, although most of the covariance of CM with NDD symptoms was explained by common genetic effects. Conclusions Maltreated children are at higher risk of having multiple NDDs. Our findings are, however, not consistent with the notion that CM causes the increased NDD load in maltreated children. Maltreated children should receive a full neurodevelopmental assessment, and clinicians should be aware that children with multiple NDDs are at higher risk of maltreatment. En ligne : http://dx.doi.org/10.1111/jcpp.12682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 Eating Problems in Autistic Females and Males: A Co-twin Control Study / K. LUNDIN REMNÉLIUS in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Eating Problems in Autistic Females and Males: A Co-twin Control Study Type de document : Texte imprimé et/ou numérique Auteurs : K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3153-3168 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Autistic Disorder/genetics Diseases in Twins/genetics Female Humans Male Twins, Dizygotic Twins, Monozygotic Autism Co-twin control design Eating Gender differences lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168[article] Eating Problems in Autistic Females and Males: A Co-twin Control Study [Texte imprimé et/ou numérique] / K. LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur . - p.3153-3168.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168
Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Autistic Disorder/genetics Diseases in Twins/genetics Female Humans Male Twins, Dizygotic Twins, Monozygotic Autism Co-twin control design Eating Gender differences lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477