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Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms / H. K. HARRIS in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
[article]
Titre : Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : H. K. HARRIS, Auteur ; C. LEE, Auteur ; G. D. SIDERIDIS, Auteur ; William J. BARBARESI, Auteur ; E. HARSTAD, Auteur Article en page(s) : p.4471-4485 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Child, Preschool Cognition Communication Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Retrospective Studies Autism spectrum disorder Core symptoms Subgroups Toddlers Index. décimale : PER Périodiques Résumé : The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04879-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4471-4485[article] Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms [Texte imprimé et/ou numérique] / H. K. HARRIS, Auteur ; C. LEE, Auteur ; G. D. SIDERIDIS, Auteur ; William J. BARBARESI, Auteur ; E. HARSTAD, Auteur . - p.4471-4485.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4471-4485
Mots-clés : Autism Spectrum Disorder/diagnosis Child, Preschool Cognition Communication Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Retrospective Studies Autism spectrum disorder Core symptoms Subgroups Toddlers Index. décimale : PER Périodiques Résumé : The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04879-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children / H. MAZAHERY in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
[article]
Titre : A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children Type de document : Texte imprimé et/ou numérique Auteurs : H. MAZAHERY, Auteur ; C. A. CONLON, Auteur ; K. L. BECK, Auteur ; O. MUGRIDGE, Auteur ; M. C. KRUGER, Auteur ; W. STONEHOUSE, Auteur ; C. A. CAMARGO, Auteur ; B. J. MEYER, Auteur ; B. TSANG, Auteur ; B. JONES, Auteur ; P. R. VON HURST, Auteur Article en page(s) : p.1778-1794 Langues : Anglais (eng) Mots-clés : Autism Children Core symptoms Intervention Omega-3 Supplement Vitamin D Index. décimale : PER Périodiques Résumé : We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made. En ligne : http://dx.doi.org/10.1007/s10803-018-3860-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1778-1794[article] A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children [Texte imprimé et/ou numérique] / H. MAZAHERY, Auteur ; C. A. CONLON, Auteur ; K. L. BECK, Auteur ; O. MUGRIDGE, Auteur ; M. C. KRUGER, Auteur ; W. STONEHOUSE, Auteur ; C. A. CAMARGO, Auteur ; B. J. MEYER, Auteur ; B. TSANG, Auteur ; B. JONES, Auteur ; P. R. VON HURST, Auteur . - p.1778-1794.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1778-1794
Mots-clés : Autism Children Core symptoms Intervention Omega-3 Supplement Vitamin D Index. décimale : PER Périodiques Résumé : We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made. En ligne : http://dx.doi.org/10.1007/s10803-018-3860-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 Conceptualizing skills that are most critical in diagnosing autism / Johnny L. MATSON in Research in Autism Spectrum Disorders, 8-8 (August 2014)
[article]
Titre : Conceptualizing skills that are most critical in diagnosing autism Type de document : Texte imprimé et/ou numérique Auteurs : Johnny L. MATSON, Auteur ; Jina JANG, Auteur Article en page(s) : p.968-973 Langues : Anglais (eng) Mots-clés : Core symptoms Autism Differential diagnosis DSM-5 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) consist of a broad but heterogeneous group of symptoms. This factor has resulted in a debate as to whether the disorder is a unitary construct or a group of related disorders with a similar symptom presentation. Additionally, some core symptoms are seen in other developmental disabilities such as intellectual disability. This review covers these and related issues in the context of what symptoms are most critical for diagnosing ASD and distinguishing it from other developmental disabilities. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.04.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Research in Autism Spectrum Disorders > 8-8 (August 2014) . - p.968-973[article] Conceptualizing skills that are most critical in diagnosing autism [Texte imprimé et/ou numérique] / Johnny L. MATSON, Auteur ; Jina JANG, Auteur . - p.968-973.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-8 (August 2014) . - p.968-973
Mots-clés : Core symptoms Autism Differential diagnosis DSM-5 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) consist of a broad but heterogeneous group of symptoms. This factor has resulted in a debate as to whether the disorder is a unitary construct or a group of related disorders with a similar symptom presentation. Additionally, some core symptoms are seen in other developmental disabilities such as intellectual disability. This review covers these and related issues in the context of what symptoms are most critical for diagnosing ASD and distinguishing it from other developmental disabilities. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.04.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials / Umberto PROVENZANI in Autism, 24-2 (February 2020)
[article]
Titre : What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Umberto PROVENZANI, Auteur ; Laura FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; Stefano DAMIANI, Auteur ; Marco VERCESI, Auteur ; Nicholas MEYER, Auteur ; Matteo ROCCHETTI, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.274-284 Langues : Anglais (eng) Mots-clés : autism spectrum disorder core symptoms outcome measures systematic review trials Index. décimale : PER Périodiques Résumé : The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of Knowledge(SM) database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached. En ligne : http://dx.doi.org/10.1177/1362361319854641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Autism > 24-2 (February 2020) . - p.274-284[article] What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials [Texte imprimé et/ou numérique] / Umberto PROVENZANI, Auteur ; Laura FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; Stefano DAMIANI, Auteur ; Marco VERCESI, Auteur ; Nicholas MEYER, Auteur ; Matteo ROCCHETTI, Auteur ; Pierluigi POLITI, Auteur . - p.274-284.
Langues : Anglais (eng)
in Autism > 24-2 (February 2020) . - p.274-284
Mots-clés : autism spectrum disorder core symptoms outcome measures systematic review trials Index. décimale : PER Périodiques Résumé : The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of Knowledge(SM) database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached. En ligne : http://dx.doi.org/10.1177/1362361319854641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415