21 recherche sur le mot-clé 'Cortical thickness'

Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability / Derek S. ANDREWS in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.486-497 Titre : Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability Type de document : texte imprimé Auteurs : Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.486-497 Langues : Anglais (eng) Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n 88, mean age 5.37 years) with a large range of intellectual ability (IQ 19 133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n 53, mean age 5.29 years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ?? 70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability [texte imprimé] / Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.486-497. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.486-497 Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n 88, mean age 5.37 years) with a large range of intellectual ability (IQ 19 133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n 53, mean age 5.29 years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ?? 70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study / Jung-Chi CHANG in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202689 Titre : Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study Type de document : texte imprimé Auteurs : Jung-Chi CHANG, Auteur ; Yu-Chieh CHEN, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.202689 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  MRI  Cortical thickness  Longitudinal  Daily executive function  Autistic features Index. décimale : PER Périodiques Résumé : Background The longitudinal brain structural changes and their relationships with clinical features have not been comprehensively established in individuals with autism spectrum disorder (ASD), and existing analyses have mainly focused on Western samples. This study compared change rates of cortical thickness between participants with ASD and typically developing control (TDC) and their relationships with dynamic clinical features and executive dysfunction in an East Asian sample. Methods We assessed 86 ASD and 82 TDC participants at two time points with structural MRI and autistic features and executive dysfunction measures. We used surface-based morphometry to identify the differences in developmental patterns between the ASD and TDC groups. We then examined the relationships between specific brain regions that vary developmentally and clinical parameters. Results Seven clusters were identified, showing accelerating cortical thinning in the ASD participants, including the left inferior temporal, pars orbitalis, inferior parietal, pars opercularis, right middle temporal, and bilateral rostral middle frontal regions. Greater thinning rates in the left inferior parietal and left pars opercularis regions correlated with accelerated increases in autistic features in the ASD group. Greater thinning rates in the left inferior parietal region were associated with greater executive deterioration. These structural changes also predicted social and executive dysfunction in follow-up assessments. Exploratory cross-lagged panel modeling further suggested that baseline cortical thickness in the left pars opercularis predicted social challenges at follow-up, independent of baseline autistic features. Our findings indicate that distinct developmental changes in cortical thickness are associated with social and executive dysfunction, indicating potential pseudonormalization processes that occur from adolescence to early adulthood in this population. Conclusions Our study elucidates neurodevelopmental correlates and trajectories of clinical deficits in ASD among Asian individuals, extending our understanding of brain-behavior relationships from adolescence to early adulthood. En ligne : https://doi.org/10.1016/j.reia.2025.202689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Cortical thickness variations and their relation to social and executive dysfunctions in autism spectrum disorder among an East Asian population: A longitudinal MRI study [texte imprimé] / Jung-Chi CHANG, Auteur ; Yu-Chieh CHEN, Auteur ; Susan Shur-Fen GAU, Auteur . - p.202689. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202689 Mots-clés : Autism spectrum disorder  MRI  Cortical thickness  Longitudinal  Daily executive function  Autistic features Index. décimale : PER Périodiques Résumé : Background The longitudinal brain structural changes and their relationships with clinical features have not been comprehensively established in individuals with autism spectrum disorder (ASD), and existing analyses have mainly focused on Western samples. This study compared change rates of cortical thickness between participants with ASD and typically developing control (TDC) and their relationships with dynamic clinical features and executive dysfunction in an East Asian sample. Methods We assessed 86 ASD and 82 TDC participants at two time points with structural MRI and autistic features and executive dysfunction measures. We used surface-based morphometry to identify the differences in developmental patterns between the ASD and TDC groups. We then examined the relationships between specific brain regions that vary developmentally and clinical parameters. Results Seven clusters were identified, showing accelerating cortical thinning in the ASD participants, including the left inferior temporal, pars orbitalis, inferior parietal, pars opercularis, right middle temporal, and bilateral rostral middle frontal regions. Greater thinning rates in the left inferior parietal and left pars opercularis regions correlated with accelerated increases in autistic features in the ASD group. Greater thinning rates in the left inferior parietal region were associated with greater executive deterioration. These structural changes also predicted social and executive dysfunction in follow-up assessments. Exploratory cross-lagged panel modeling further suggested that baseline cortical thickness in the left pars opercularis predicted social challenges at follow-up, independent of baseline autistic features. Our findings indicate that distinct developmental changes in cortical thickness are associated with social and executive dysfunction, indicating potential pseudonormalization processes that occur from adolescence to early adulthood in this population. Conclusions Our study elucidates neurodevelopmental correlates and trajectories of clinical deficits in ASD among Asian individuals, extending our understanding of brain-behavior relationships from adolescence to early adulthood. En ligne : https://doi.org/10.1016/j.reia.2025.202689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder / Hsiang-Yun CHIEN in Autism Research, 8-6 (December 2015)  

Public ISBD [article]  inAutism Research > 8-6 (December 2015) . - p.694-708 Titre : Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur Article en page(s) : p.694-708 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  mirror neuron system  diffusion spectrum imaging  cortical thickness  white matter integrity  tractography  social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder [texte imprimé] / Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur . - p.694-708. Langues : Anglais (eng) in Autism Research > 8-6 (December 2015) . - p.694-708 Mots-clés : autism spectrum disorder  mirror neuron system  diffusion spectrum imaging  cortical thickness  white matter integrity  tractography  social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care / Marta KOROM in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.73-84 Titre : Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care Type de document : texte imprimé Auteurs : Marta KOROM, Auteur ; Nim TOTTENHAM, Auteur ; Emilio A. VALADEZ, Auteur ; Mary DOZIER, Auteur Article en page(s) : p.73-84 Langues : Anglais (eng) Mots-clés : anxious/depressive symptoms  caregiving quality  cortical thickness  early adversity  pial surface area Index. décimale : PER Périodiques Résumé : A variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08-12.14; Mage = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children. En ligne : https://doi.org/10.1017/S0954579421000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care [texte imprimé] / Marta KOROM, Auteur ; Nim TOTTENHAM, Auteur ; Emilio A. VALADEZ, Auteur ; Mary DOZIER, Auteur . - p.73-84. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.73-84 Mots-clés : anxious/depressive symptoms  caregiving quality  cortical thickness  early adversity  pial surface area Index. décimale : PER Périodiques Résumé : A variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08-12.14; Mage = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children. En ligne : https://doi.org/10.1017/S0954579421000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing / Andrea L. GOLD in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1154-1164 Titre : Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing Type de document : texte imprimé Auteurs : Andrea L. GOLD, Auteur ; Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Daniel S. BUSSO, Auteur ; Hilary K. LAMBERT, Auteur ; Sonia ALVES, Auteur ; Daniel S. PINE, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1154-1164 Langues : Anglais (eng) Mots-clés : Abuse  childhood adversity  ventromedial prefrontal cortex  temporal cortex  cortical thickness Index. décimale : PER Périodiques Résumé : Background Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared with nonabused adolescents, although most prior research is based on adults and volume-based measures. This study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence. Methods Structural MRI scans were obtained from 21 adolescents exposed to physical and/or sexual abuse and 37 nonabused adolescents (ages 13–20). Abuse was operationalized using dichotomous and continuous measures. We examined associations between abuse and brain structure in several a priori-defined regions, controlling for parental education, age, sex, race, and total brain volume for subcortical GMV. Significance was evaluated at p < .05 with a false discovery rate correction. Results Child abuse exposure and severity were associated with reduced thickness in ventromedial prefrontal cortex (PFC), right lateral orbitofrontal cortex, right inferior frontal gyrus, bilateral parahippocampal gyrus (PHG), left temporal pole, and bilateral inferior, right middle, and right superior temporal gyri. Neither abuse measure predicted cortical surface area or subcortical GMV. Bilateral PHG thickness was inversely related to externalizing symptoms. Conclusions Child abuse, an experience characterized by a high degree of threat, is associated with reduced cortical thickness in ventromedial and ventrolateral PFC and medial and lateral temporal cortex in adolescence. Reduced PHG thickness may be a mediator linking abuse with externalizing psychopathology, although prospective research is needed to evaluate this possibility. En ligne : http://dx.doi.org/10.1111/jcpp.12630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing [texte imprimé] / Andrea L. GOLD, Auteur ; Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Daniel S. BUSSO, Auteur ; Hilary K. LAMBERT, Auteur ; Sonia ALVES, Auteur ; Daniel S. PINE, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1154-1164. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1154-1164 Mots-clés : Abuse  childhood adversity  ventromedial prefrontal cortex  temporal cortex  cortical thickness Index. décimale : PER Périodiques Résumé : Background Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared with nonabused adolescents, although most prior research is based on adults and volume-based measures. This study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence. Methods Structural MRI scans were obtained from 21 adolescents exposed to physical and/or sexual abuse and 37 nonabused adolescents (ages 13–20). Abuse was operationalized using dichotomous and continuous measures. We examined associations between abuse and brain structure in several a priori-defined regions, controlling for parental education, age, sex, race, and total brain volume for subcortical GMV. Significance was evaluated at p < .05 with a false discovery rate correction. Results Child abuse exposure and severity were associated with reduced thickness in ventromedial prefrontal cortex (PFC), right lateral orbitofrontal cortex, right inferior frontal gyrus, bilateral parahippocampal gyrus (PHG), left temporal pole, and bilateral inferior, right middle, and right superior temporal gyri. Neither abuse measure predicted cortical surface area or subcortical GMV. Bilateral PHG thickness was inversely related to externalizing symptoms. Conclusions Child abuse, an experience characterized by a high degree of threat, is associated with reduced cortical thickness in ventromedial and ventrolateral PFC and medial and lateral temporal cortex in adolescence. Reduced PHG thickness may be a mediator linking abuse with externalizing psychopathology, although prospective research is needed to evaluate this possibility. En ligne : http://dx.doi.org/10.1111/jcpp.12630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Effects of age and symptomatology on cortical thickness in autism spectrum disorders / Krissy DOYLE-THOMAS in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

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Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder / Haruhisa OHTA in Autism Research, 9-2 (February 2016)  

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Is there a bit of autism in all of us? Autism spectrum traits are related to cortical thickness differences in both autism and typical development / Line GEBAUER in Research in Autism Spectrum Disorders, 13-14 (May 2015)  

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Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults / David JAMES in Autism Research, 15-6 (June 2022)  

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Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder / Molly D.B. PRIGGE in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

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