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Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence / A. A. LUSSIER in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
[article]
Titre : Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : A. A. LUSSIER, Auteur ; M. HAWRILENKO, Auteur ; M. J. WANG, Auteur ; Karmel W. CHOI, Auteur ; J. CERUTTI, Auteur ; Y. ZHU, Auteur ; E. C. DUNN, Auteur Article en page(s) : p.895-904 Langues : Anglais (eng) Mots-clés : Adolescent Adult Child Depression Depressive Disorder, Major/epidemiology/genetics Genetic Predisposition to Disease/genetics Genome-Wide Association Study Humans Longitudinal Studies Prospective Studies Alspac Depression trajectories development longitudinal polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom trajectories assessed from childhood to adolescence. METHODS: Data came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample = 7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4-16.5 years of age (class, onset, and cumulative burden). Trajectories were constructed using a growth mixture model with structured residuals. PRS were generated from the summary statistics of a genome-wide association study of depression risk using data from the Psychiatric Genomics Consortium, UK Biobank, and 23andMe, Inc. We used MAGMA to identify gene-level associations with these measures. RESULTS: Youth were classified into six classes of depressive symptom trajectories: high/renitent (27.9% of youth), high/reversing (9.1%), childhood decrease (7.3%), late childhood peak (3.3%), adolescent spike (2.5%), and minimal symptoms (49.9%). PRS discriminated between youth in the late childhood peak, high/reversing, and high/renitent classes compared to the minimal symptoms and childhood decrease classes. No significant associations were detected at the gene level. CONCLUSIONS: This study highlights differences in polygenic loading for depressive symptoms across childhood and adolescence, particularly among youths with high symptoms in early adolescence, regardless of age-independent patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.895-904[article] Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence [Texte imprimé et/ou numérique] / A. A. LUSSIER, Auteur ; M. HAWRILENKO, Auteur ; M. J. WANG, Auteur ; Karmel W. CHOI, Auteur ; J. CERUTTI, Auteur ; Y. ZHU, Auteur ; E. C. DUNN, Auteur . - p.895-904.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.895-904
Mots-clés : Adolescent Adult Child Depression Depressive Disorder, Major/epidemiology/genetics Genetic Predisposition to Disease/genetics Genome-Wide Association Study Humans Longitudinal Studies Prospective Studies Alspac Depression trajectories development longitudinal polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom trajectories assessed from childhood to adolescence. METHODS: Data came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample = 7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4-16.5 years of age (class, onset, and cumulative burden). Trajectories were constructed using a growth mixture model with structured residuals. PRS were generated from the summary statistics of a genome-wide association study of depression risk using data from the Psychiatric Genomics Consortium, UK Biobank, and 23andMe, Inc. We used MAGMA to identify gene-level associations with these measures. RESULTS: Youth were classified into six classes of depressive symptom trajectories: high/renitent (27.9% of youth), high/reversing (9.1%), childhood decrease (7.3%), late childhood peak (3.3%), adolescent spike (2.5%), and minimal symptoms (49.9%). PRS discriminated between youth in the late childhood peak, high/reversing, and high/renitent classes compared to the minimal symptoms and childhood decrease classes. No significant associations were detected at the gene level. CONCLUSIONS: This study highlights differences in polygenic loading for depressive symptoms across childhood and adolescence, particularly among youths with high symptoms in early adolescence, regardless of age-independent patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Multisystemic supports and adolescent resilience to depression over time: A South African mixed methods study / Linda THERON ; Michael UNGAR in Development and Psychopathology, 35-5 (December 2023)
[article]
Titre : Multisystemic supports and adolescent resilience to depression over time: A South African mixed methods study Type de document : Texte imprimé et/ou numérique Auteurs : Linda THERON, Auteur ; Michael UNGAR, Auteur Article en page(s) : p.2365-2383 Mots-clés : African adolescents culturally responsive resilience-enablers depression trajectories multisystemic resilience resource diversity Index. décimale : PER Périodiques Résumé : In sub-Saharan countries, like South Africa, there is scant understanding of adolescent resilience to depression over time; the multisystemic resource combinations that support such resilience; and whether more diverse resource combinations yield better mental health dividends. In response, we conducted a longitudinal concurrent nested mixed methods study with 223 South African adolescents (mean age: 17.16 years, SD = 1.73; 64.60% girls; 81.60% Black). Using longitudinal mixture modeling, the quantitative study identified trajectories of depression and associations between trajectory membership and resource diversity. Using a draw-and-write methodology and reflexive thematic analyses, the qualitative study explored the resource diversity associated with each trajectory. Taken together, these studies identified four depression trajectories (Stable Low; Declining; Worsening; Chronic High) with varying resource diversity at baseline and over time. Resource diversity was inclusive of personal, relational, contextual, and culturally valued resources in both the Stable Low and Declining trajectories, with emphasis on relational supports. Personal resources were emphasized in the Worsening and Chronic High trajectories, and culturally valued and contextual resources de-emphasized. In summary, resource constellations characterized by within and across system diversity and cultural responsiveness are more protective and will be key to advancing sub-Saharan adolescent mental health. En ligne : https://dx.doi.org/10.1017/S0954579423000494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519
in Development and Psychopathology > 35-5 (December 2023) . - p.2365-2383[article] Multisystemic supports and adolescent resilience to depression over time: A South African mixed methods study [Texte imprimé et/ou numérique] / Linda THERON, Auteur ; Michael UNGAR, Auteur . - p.2365-2383.
in Development and Psychopathology > 35-5 (December 2023) . - p.2365-2383
Mots-clés : African adolescents culturally responsive resilience-enablers depression trajectories multisystemic resilience resource diversity Index. décimale : PER Périodiques Résumé : In sub-Saharan countries, like South Africa, there is scant understanding of adolescent resilience to depression over time; the multisystemic resource combinations that support such resilience; and whether more diverse resource combinations yield better mental health dividends. In response, we conducted a longitudinal concurrent nested mixed methods study with 223 South African adolescents (mean age: 17.16 years, SD = 1.73; 64.60% girls; 81.60% Black). Using longitudinal mixture modeling, the quantitative study identified trajectories of depression and associations between trajectory membership and resource diversity. Using a draw-and-write methodology and reflexive thematic analyses, the qualitative study explored the resource diversity associated with each trajectory. Taken together, these studies identified four depression trajectories (Stable Low; Declining; Worsening; Chronic High) with varying resource diversity at baseline and over time. Resource diversity was inclusive of personal, relational, contextual, and culturally valued resources in both the Stable Low and Declining trajectories, with emphasis on relational supports. Personal resources were emphasized in the Worsening and Chronic High trajectories, and culturally valued and contextual resources de-emphasized. In summary, resource constellations characterized by within and across system diversity and cultural responsiveness are more protective and will be key to advancing sub-Saharan adolescent mental health. En ligne : https://dx.doi.org/10.1017/S0954579423000494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519