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Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder / V. THULASI in Autism, 23-2 (February 2019)
[article]
Titre : Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : V. THULASI, Auteur ; R. A. STEER, Auteur ; I. M. MONTEIRO, Auteur ; X. MING, Auteur Article en page(s) : p.524-530 Langues : Anglais (eng) Mots-clés : Gastrointestinal Severity Scale autism spectrum disorders constipation diarrhea gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383
in Autism > 23-2 (February 2019) . - p.524-530[article] Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder [Texte imprimé et/ou numérique] / V. THULASI, Auteur ; R. A. STEER, Auteur ; I. M. MONTEIRO, Auteur ; X. MING, Auteur . - p.524-530.
Langues : Anglais (eng)
in Autism > 23-2 (February 2019) . - p.524-530
Mots-clés : Gastrointestinal Severity Scale autism spectrum disorders constipation diarrhea gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism / A. E. SHINDLER in Journal of Autism and Developmental Disorders, 50-1 (January 2020)
[article]
Titre : Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism Type de document : Texte imprimé et/ou numérique Auteurs : A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : Autism Constipation Diarrhea Gastrointestinal dysfunction Nausea Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research. En ligne : http://dx.doi.org/10.1007/s10803-019-04231-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.76-86[article] Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism [Texte imprimé et/ou numérique] / A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur . - p.76-86.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.76-86
Mots-clés : Autism Constipation Diarrhea Gastrointestinal dysfunction Nausea Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research. En ligne : http://dx.doi.org/10.1007/s10803-019-04231-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414