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Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic / Roma A. VASA in Journal of Autism and Developmental Disorders, 52-4 (April 2022)
[article]
Titre : Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic Type de document : Texte imprimé et/ou numérique Auteurs : Roma A. VASA, Auteur ; Vini SINGH, Auteur ; Rachel G. MCDONALD, Auteur ; Carla MAZEFSKY, Auteur ; Ji Su HONG, Auteur ; Amy KEEFER, Auteur Article en page(s) : p.1762-1770 Langues : Anglais (eng) Mots-clés : Adolescent Ambulatory Care Facilities Autism Spectrum Disorder/diagnosis/epidemiology/psychology Autistic Disorder/diagnosis/epidemiology Child Humans Prevalence Autism center Children Dysregulation Screening Index. décimale : PER Périodiques Résumé : Research indicates that children with autism spectrum disorder (ASD) frequently exhibit dysregulation, which refers to poorly coordinated affective, behavioral, and cognitive responses to a given situation. We examined the characteristics of dysregulation in children presenting to a multidisciplinary ASD clinic for an ASD diagnostic evaluation. Sixty percent of children presenting for an ASD evaluation exhibited dysregulation. Dysregulation prevalence was higher in children without ASD versus with ASD (69% versus 56%). Severe dysregulation was higher in children without ASD (29% versus 16%). Both groups with severe dysregulation were equally likely to be taking psychiatric medications, however, children with ASD were less likely to be receiving therapy. These findings highlight the importance of implementing dysregulation screening and treatment protocols in ASD centers. En ligne : http://dx.doi.org/10.1007/s10803-021-05056-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1762-1770[article] Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic [Texte imprimé et/ou numérique] / Roma A. VASA, Auteur ; Vini SINGH, Auteur ; Rachel G. MCDONALD, Auteur ; Carla MAZEFSKY, Auteur ; Ji Su HONG, Auteur ; Amy KEEFER, Auteur . - p.1762-1770.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1762-1770
Mots-clés : Adolescent Ambulatory Care Facilities Autism Spectrum Disorder/diagnosis/epidemiology/psychology Autistic Disorder/diagnosis/epidemiology Child Humans Prevalence Autism center Children Dysregulation Screening Index. décimale : PER Périodiques Résumé : Research indicates that children with autism spectrum disorder (ASD) frequently exhibit dysregulation, which refers to poorly coordinated affective, behavioral, and cognitive responses to a given situation. We examined the characteristics of dysregulation in children presenting to a multidisciplinary ASD clinic for an ASD diagnostic evaluation. Sixty percent of children presenting for an ASD evaluation exhibited dysregulation. Dysregulation prevalence was higher in children without ASD versus with ASD (69% versus 56%). Severe dysregulation was higher in children without ASD (29% versus 16%). Both groups with severe dysregulation were equally likely to be taking psychiatric medications, however, children with ASD were less likely to be receiving therapy. These findings highlight the importance of implementing dysregulation screening and treatment protocols in ASD centers. En ligne : http://dx.doi.org/10.1007/s10803-021-05056-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Investigating the factor structure of the child behavior checklist dysregulation profile in children and adolescents with autism spectrum disorder / Amy KEEFER in Autism Research, 13-3 (March 2020)
[article]
Titre : Investigating the factor structure of the child behavior checklist dysregulation profile in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Amy KEEFER, Auteur ; Vini SINGH, Auteur ; Luther G. KALB, Auteur ; Carla A. MAZEFSKY, Auteur ; Roma A. VASA, Auteur Article en page(s) : p.436-443 Langues : Anglais (eng) Mots-clés : autism spectrum disorder child behavior checklist dysregulation factor analysis Index. décimale : PER Périodiques Résumé : Dysregulation has been identified as an important risk factor for the development of psychiatric disorders in individuals with autism spectrum disorder (ASD). Therefore, it is necessary to empirically characterize dysregulation and identify psychometrically sound and readily available assessment methods in the ASD population. We sought to evaluate the factor structure of the Child Behavior Checklist-Dysregulation Profile (CBCL-DP), an established dysregulation measure in neurotypical children that is derived from the CBCL, in a large, clinically referred sample of children, ages 6-18 years, with ASD (n = 727). Confirmatory factor analysis was used to characterize dysregulation and assess the validity of the CBCL-DP in children with ASD. Our findings support a bi-factor model of dysregulation in which dysregulation is a broad and distinct syndrome that is associated with the three subdomains of the CBCL-DP, anxiety/depression (AD), attention problems (AP), and aggressive behavior (AGG). Dysregulation was associated with most items in the AD and AGG domains and few items in the AP domain. This association with AD and AGG indicates that dysregulation in ASD may be conceptualized as the combined experience of internalized, negative mood states and externalized, reactive behaviors. These findings provide support as well as important caveats for the use of the CBCL-DP as a measure of dysregulation in the ASD population. Autism Res 2020, 13: 436-443. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Dysregulation is a risk factor for psychiatric disorders in ASD. This study examined if the CBCL-DP, an established measure of dysregulation in neurotypical children, can be used to assess dysregulation in children with ASD. Findings provide evidence that in ASD, dysregulation is a broad construct that exists alongside anxiety/depression, attention problems, and aggression. These findings indicate that the CBCL-DP can be considered a valid measure of dysregulation in the ASD population and could be used in clinical settings. En ligne : http://dx.doi.org/10.1002/aur.2233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Autism Research > 13-3 (March 2020) . - p.436-443[article] Investigating the factor structure of the child behavior checklist dysregulation profile in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Amy KEEFER, Auteur ; Vini SINGH, Auteur ; Luther G. KALB, Auteur ; Carla A. MAZEFSKY, Auteur ; Roma A. VASA, Auteur . - p.436-443.
Langues : Anglais (eng)
in Autism Research > 13-3 (March 2020) . - p.436-443
Mots-clés : autism spectrum disorder child behavior checklist dysregulation factor analysis Index. décimale : PER Périodiques Résumé : Dysregulation has been identified as an important risk factor for the development of psychiatric disorders in individuals with autism spectrum disorder (ASD). Therefore, it is necessary to empirically characterize dysregulation and identify psychometrically sound and readily available assessment methods in the ASD population. We sought to evaluate the factor structure of the Child Behavior Checklist-Dysregulation Profile (CBCL-DP), an established dysregulation measure in neurotypical children that is derived from the CBCL, in a large, clinically referred sample of children, ages 6-18 years, with ASD (n = 727). Confirmatory factor analysis was used to characterize dysregulation and assess the validity of the CBCL-DP in children with ASD. Our findings support a bi-factor model of dysregulation in which dysregulation is a broad and distinct syndrome that is associated with the three subdomains of the CBCL-DP, anxiety/depression (AD), attention problems (AP), and aggressive behavior (AGG). Dysregulation was associated with most items in the AD and AGG domains and few items in the AP domain. This association with AD and AGG indicates that dysregulation in ASD may be conceptualized as the combined experience of internalized, negative mood states and externalized, reactive behaviors. These findings provide support as well as important caveats for the use of the CBCL-DP as a measure of dysregulation in the ASD population. Autism Res 2020, 13: 436-443. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Dysregulation is a risk factor for psychiatric disorders in ASD. This study examined if the CBCL-DP, an established measure of dysregulation in neurotypical children, can be used to assess dysregulation in children with ASD. Findings provide evidence that in ASD, dysregulation is a broad construct that exists alongside anxiety/depression, attention problems, and aggression. These findings indicate that the CBCL-DP can be considered a valid measure of dysregulation in the ASD population and could be used in clinical settings. En ligne : http://dx.doi.org/10.1002/aur.2233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 Correlates of the CBCL-dysregulation profile in preschool-aged children / Jiyon KIM in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)
[article]
Titre : Correlates of the CBCL-dysregulation profile in preschool-aged children Type de document : Texte imprimé et/ou numérique Auteurs : Jiyon KIM, Auteur ; Gabrielle A. CARLSON, Auteur ; Stephanie E. MEYER, Auteur ; Sara J. BUFFERD, Auteur ; Lea R. DOUGHERTY, Auteur ; Margaret DYSON, Auteur ; Rebecca S. LAPTOOK, Auteur ; Thomas M. OLINO, Auteur ; Daniel N. KLEIN, Auteur Année de publication : 2012 Article en page(s) : p.918-26 Langues : Anglais (eng) Mots-clés : CBCL dysregulation preschool children comorbidity Index. décimale : PER Périodiques Résumé : Background: A growing literature indicates that the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) identifies youths with heightened risk for severe psychopathology, comorbidity, and impairment. However, this work has focused on school-age children and adolescents; no studies have examined whether preschool-aged children with the CBCL-DP exhibit a similar constellation of problems. Method: Using a community sample of preschoolers, we compared children with (N = 61) and without (N = 488) the CBCL-DP on a broad range of variables assessed using multiple methods. Results: Univariate analyses revealed numerous differences between children with the CBCL-DP and their peers on psychiatric symptomatology, temperament, parenting behavior, and parental personality, psychopathology, and marital functioning. In multivariate analyses, children with the CBCL-DP exhibited greater temperamental negative affectivity and lower effortful control. They also had more depressive and oppositional defiant symptoms, as well as greater functional impairment. Parents of CBCL-DP children reported engaging in more punitive, controlling parenting behavior than parents of non-profile children. Conclusions: In a non-clinical sample of preschoolers, the CBCL-DP is associated with extensive emotional and behavioral dysregulation and maladaptive parenting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02546.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179
in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.918-26[article] Correlates of the CBCL-dysregulation profile in preschool-aged children [Texte imprimé et/ou numérique] / Jiyon KIM, Auteur ; Gabrielle A. CARLSON, Auteur ; Stephanie E. MEYER, Auteur ; Sara J. BUFFERD, Auteur ; Lea R. DOUGHERTY, Auteur ; Margaret DYSON, Auteur ; Rebecca S. LAPTOOK, Auteur ; Thomas M. OLINO, Auteur ; Daniel N. KLEIN, Auteur . - 2012 . - p.918-26.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.918-26
Mots-clés : CBCL dysregulation preschool children comorbidity Index. décimale : PER Périodiques Résumé : Background: A growing literature indicates that the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) identifies youths with heightened risk for severe psychopathology, comorbidity, and impairment. However, this work has focused on school-age children and adolescents; no studies have examined whether preschool-aged children with the CBCL-DP exhibit a similar constellation of problems. Method: Using a community sample of preschoolers, we compared children with (N = 61) and without (N = 488) the CBCL-DP on a broad range of variables assessed using multiple methods. Results: Univariate analyses revealed numerous differences between children with the CBCL-DP and their peers on psychiatric symptomatology, temperament, parenting behavior, and parental personality, psychopathology, and marital functioning. In multivariate analyses, children with the CBCL-DP exhibited greater temperamental negative affectivity and lower effortful control. They also had more depressive and oppositional defiant symptoms, as well as greater functional impairment. Parents of CBCL-DP children reported engaging in more punitive, controlling parenting behavior than parents of non-profile children. Conclusions: In a non-clinical sample of preschoolers, the CBCL-DP is associated with extensive emotional and behavioral dysregulation and maladaptive parenting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02546.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis / Martin HOLTMANN in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)
[article]
Titre : The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis Type de document : Texte imprimé et/ou numérique Auteurs : Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur Année de publication : 2011 Article en page(s) : p.139-147 Langues : Anglais (eng) Mots-clés : Dysregulation childhood comorbidity longitudinal irritability depression ADHD substance use suicidality CBCL bipolar Index. décimale : PER Périodiques Résumé : Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP.
Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment.
Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general.
Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147[article] The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis [Texte imprimé et/ou numérique] / Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur . - 2011 . - p.139-147.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147
Mots-clés : Dysregulation childhood comorbidity longitudinal irritability depression ADHD substance use suicidality CBCL bipolar Index. décimale : PER Périodiques Résumé : Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP.
Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment.
Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general.
Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder / M. MILLER in Journal of Child Psychology and Psychiatry, 60-5 (May 2019)
[article]
Titre : The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.516-523 Langues : Anglais (eng) Mots-clés : Dysregulation autism spectrum disorder high risk preschool siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392
in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523[article] The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder [Texte imprimé et/ou numérique] / M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur . - p.516-523.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523
Mots-clés : Dysregulation autism spectrum disorder high risk preschool siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder / Hsiang-Yuan LIN in Autism, 24-5 (July 2020)
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