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Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome / Lindsay J. MULLIN in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome Type de document : texte imprimé Auteurs : Lindsay J. MULLIN, Auteur ; Joshua RUTSOHN, Auteur ; Julia L. GROSS, Auteur ; Kelly E. CARAVELLA, Auteur ; Rebecca L. GRZADZINSKI, Auteur ; Leigh Anne WEISENFELD, Auteur ; Lisa FLAKE, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Jason J. WOLFF, Auteur ; Mark D. SHEN, Auteur ; Joseph PIVEN, Auteur ; Heather C. HAZLETT, Auteur ; Jessica B. GIRAULT, Auteur Langues : Anglais (eng) Mots-clés : Infant  Humans  Fragile X Syndrome/complications/psychology  Autism Spectrum Disorder/complications/psychology  Autistic Disorder  Language  Cognition  Autism  Behavioral  Cognitive  Development  Fragile X syndrome  Infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Recent studies have uncovered important differences between infants with fragile X syndrome (FXS) and infants with familial history of autism spectrum disorder who go on to develop autism themselves (FH-ASD), including differences in brain development and behavior. Thus far, there have been no studies longitudinally investigating differential developmental skill profiles in FXS and FH-ASD infants. METHODS: The current study contrasted longitudinal trajectories of verbal (expressive and receptive language) and nonverbal (gross and fine motor, visual reception) skills in FXS and FH-ASD infants, compared to FH infants who did not develop ASD (FH-nonASD) and typically developing controls. RESULTS: Infants with FXS showed delays on a nonverbal composite compared to FH-ASD (as well as FH-nonASD and control) infants as early as 6 months of age. By 12 months an ordinal pattern of scores was established between groups on all domains tested, such that controls > FH-nonASD > FH-ASD > FXS. This pattern persisted through 24 months. Cognitive level differentially influenced developmental trajectories for FXS and FH-ASD. CONCLUSIONS: Our results demonstrate detectable group differences by 6 months between FXS and FH-ASD as well as differential trajectories on each domain throughout infancy. This work further highlights an earlier onset of global cognitive delays in FXS and, conversely, a protracted period of more slowly emerging delays in FH-ASD. Divergent neural and cognitive development in infancy between FXS and FH-ASD contributes to our understanding of important distinctions in the development and behavioral phenotype of these two groups. En ligne : https://dx.doi.org/10.1186/s11689-024-09519-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome [texte imprimé] / Lindsay J. MULLIN, Auteur ; Joshua RUTSOHN, Auteur ; Julia L. GROSS, Auteur ; Kelly E. CARAVELLA, Auteur ; Rebecca L. GRZADZINSKI, Auteur ; Leigh Anne WEISENFELD, Auteur ; Lisa FLAKE, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Jason J. WOLFF, Auteur ; Mark D. SHEN, Auteur ; Joseph PIVEN, Auteur ; Heather C. HAZLETT, Auteur ; Jessica B. GIRAULT, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Infant  Humans  Fragile X Syndrome/complications/psychology  Autism Spectrum Disorder/complications/psychology  Autistic Disorder  Language  Cognition  Autism  Behavioral  Cognitive  Development  Fragile X syndrome  Infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Recent studies have uncovered important differences between infants with fragile X syndrome (FXS) and infants with familial history of autism spectrum disorder who go on to develop autism themselves (FH-ASD), including differences in brain development and behavior. Thus far, there have been no studies longitudinally investigating differential developmental skill profiles in FXS and FH-ASD infants. METHODS: The current study contrasted longitudinal trajectories of verbal (expressive and receptive language) and nonverbal (gross and fine motor, visual reception) skills in FXS and FH-ASD infants, compared to FH infants who did not develop ASD (FH-nonASD) and typically developing controls. RESULTS: Infants with FXS showed delays on a nonverbal composite compared to FH-ASD (as well as FH-nonASD and control) infants as early as 6 months of age. By 12 months an ordinal pattern of scores was established between groups on all domains tested, such that controls > FH-nonASD > FH-ASD > FXS. This pattern persisted through 24 months. Cognitive level differentially influenced developmental trajectories for FXS and FH-ASD. CONCLUSIONS: Our results demonstrate detectable group differences by 6 months between FXS and FH-ASD as well as differential trajectories on each domain throughout infancy. This work further highlights an earlier onset of global cognitive delays in FXS and, conversely, a protracted period of more slowly emerging delays in FH-ASD. Divergent neural and cognitive development in infancy between FXS and FH-ASD contributes to our understanding of important distinctions in the development and behavioral phenotype of these two groups. En ligne : https://dx.doi.org/10.1186/s11689-024-09519-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575