Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
4 recherche sur le mot-clé 'Gastrointestinal dysfunction'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders / Roni Enten VISSOKER in Research in Autism Spectrum Disorders, 12 (April 2015)
[article]
Titre : Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roni Enten VISSOKER, Auteur ; Yael LATZER, Auteur ; Eynat GAL, Auteur Article en page(s) : p.10-21 Langues : Anglais (eng) Mots-clés : Eating problems Feeding problems Gastrointestinal dysfunction ASD Autism Index. décimale : PER Périodiques Résumé : Abstract Eating and feeding problems, most commonly food selectivity or picky eating, are common among children with ASD. While these behaviors are typically addressed through occupational or behavior-based therapeutic approaches, increasing evidence shows than in many cases, such eating and feeding problems may be organic and stem from some form of underlying gastrointestinal dysfunction. This review highlights the literature on eating/feeding problems in children with ASD, as well as the contributing factors to eating problems and their nutritional implications in this population. In addition, the various manifestations and origins of gastrointestinal dysfunction in ASD are included. Ten relevant studies that address eating and feeding problems and gastrointestinal (GI) symptoms and dysfunction in children with ASD and the possible mechanisms underlying the eating/feeding problems in children with ASD are discussed. This review suggests a strong relationship and significant correlations between eating problems and gastrointestinal dysfunction. Further exploration of their relationship and etiology for the development of interventions are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.10-21[article] Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Roni Enten VISSOKER, Auteur ; Yael LATZER, Auteur ; Eynat GAL, Auteur . - p.10-21.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.10-21
Mots-clés : Eating problems Feeding problems Gastrointestinal dysfunction ASD Autism Index. décimale : PER Périodiques Résumé : Abstract Eating and feeding problems, most commonly food selectivity or picky eating, are common among children with ASD. While these behaviors are typically addressed through occupational or behavior-based therapeutic approaches, increasing evidence shows than in many cases, such eating and feeding problems may be organic and stem from some form of underlying gastrointestinal dysfunction. This review highlights the literature on eating/feeding problems in children with ASD, as well as the contributing factors to eating problems and their nutritional implications in this population. In addition, the various manifestations and origins of gastrointestinal dysfunction in ASD are included. Ten relevant studies that address eating and feeding problems and gastrointestinal (GI) symptoms and dysfunction in children with ASD and the possible mechanisms underlying the eating/feeding problems in children with ASD are discussed. This review suggests a strong relationship and significant correlations between eating problems and gastrointestinal dysfunction. Further exploration of their relationship and etiology for the development of interventions are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings / Shakuntla V. GONDALIA in Autism Research, 5-6 (December 2012)
[article]
Titre : Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings Type de document : Texte imprimé et/ou numérique Auteurs : Shakuntla V. GONDALIA, Auteur ; Enzo A. PALOMBO, Auteur ; Simon R. KNOWLES, Auteur ; Stephen B. COX, Auteur ; Denny MEYER, Auteur ; David W. AUSTIN, Auteur Article en page(s) : p.419-427 Mots-clés : faecal microbiota pyrosequencing autism spectrum disorder gastrointestinal dysfunction Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Autism Research > 5-6 (December 2012) . - p.419-427[article] Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings [Texte imprimé et/ou numérique] / Shakuntla V. GONDALIA, Auteur ; Enzo A. PALOMBO, Auteur ; Simon R. KNOWLES, Auteur ; Stephen B. COX, Auteur ; Denny MEYER, Auteur ; David W. AUSTIN, Auteur . - p.419-427.
in Autism Research > 5-6 (December 2012) . - p.419-427
Mots-clés : faecal microbiota pyrosequencing autism spectrum disorder gastrointestinal dysfunction Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 A preliminary study of pharmacogenetic biomarkers for individuals with autism and gastrointestinal dysfunction / A. E. SHINDLER in Research in Autism Spectrum Disorders, 71 (March 2020)
[article]
Titre : A preliminary study of pharmacogenetic biomarkers for individuals with autism and gastrointestinal dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur Article en page(s) : p.101516 Langues : Anglais (eng) Mots-clés : ASD Gastrointestinal dysfunction Pharmacogenetics Antidepressants Antipsychotics Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) symptoms are commonly treated with a variety of pharmaceuticals which can have adverse side effects. A study of pharmacogenetic biomarkers for ASD medications and association with gastrointestinal (GI) dysfunction symptoms was conducted in individuals diagnosed with autism and/or GI dysfunction to provide further information on the genetic risk in relation to treatment effectiveness. Methods A total of sixty participants were recruited, 10 with autism and GI dysfunction, 21 with GI dysfunction (without autism) and 29 without autism or GI dysfunction (typical controls). Buccal cell samples were collected and sequenced. A GI dysfunction questionnaire which included questions regarding prescription of medications associated with treating ASD symptoms was provided to the participants. To calculate Odds Ratios and compare the average of risk allele expression frequency of the SNPS being investigated, the sequencing and questionnaire data were analyzed using the epiR package and Welch Two Sample T-tests, respectively, using the R statistics program. The Bonferroni correction was utilized to correct for multiple comparisions. Results People in the autism group were more likely to express the risk alleles for the Cytochrome P450 family 2 subfamily C member 9 rs1057910 and Solute Carrier family 6, member 2 rs3785143 SNPs; however, after the Bonferroni correction these findings were not statistically significant (CYP2C9 rs1057910, P?=?0.074; SLC6A2, rs3785143, P?=?0.4218). Conclusions Further research is warranted to reveal the potential use of CYP2C9 and SLC6A2 SNP expression as pharmacogenetic biomarkers to determine the most appropriate medication for individuals with autism and/or GI dysfunction. En ligne : https://doi.org/10.1016/j.rasd.2020.101516 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=417
in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101516[article] A preliminary study of pharmacogenetic biomarkers for individuals with autism and gastrointestinal dysfunction [Texte imprimé et/ou numérique] / A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur . - p.101516.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101516
Mots-clés : ASD Gastrointestinal dysfunction Pharmacogenetics Antidepressants Antipsychotics Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) symptoms are commonly treated with a variety of pharmaceuticals which can have adverse side effects. A study of pharmacogenetic biomarkers for ASD medications and association with gastrointestinal (GI) dysfunction symptoms was conducted in individuals diagnosed with autism and/or GI dysfunction to provide further information on the genetic risk in relation to treatment effectiveness. Methods A total of sixty participants were recruited, 10 with autism and GI dysfunction, 21 with GI dysfunction (without autism) and 29 without autism or GI dysfunction (typical controls). Buccal cell samples were collected and sequenced. A GI dysfunction questionnaire which included questions regarding prescription of medications associated with treating ASD symptoms was provided to the participants. To calculate Odds Ratios and compare the average of risk allele expression frequency of the SNPS being investigated, the sequencing and questionnaire data were analyzed using the epiR package and Welch Two Sample T-tests, respectively, using the R statistics program. The Bonferroni correction was utilized to correct for multiple comparisions. Results People in the autism group were more likely to express the risk alleles for the Cytochrome P450 family 2 subfamily C member 9 rs1057910 and Solute Carrier family 6, member 2 rs3785143 SNPs; however, after the Bonferroni correction these findings were not statistically significant (CYP2C9 rs1057910, P?=?0.074; SLC6A2, rs3785143, P?=?0.4218). Conclusions Further research is warranted to reveal the potential use of CYP2C9 and SLC6A2 SNP expression as pharmacogenetic biomarkers to determine the most appropriate medication for individuals with autism and/or GI dysfunction. En ligne : https://doi.org/10.1016/j.rasd.2020.101516 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=417 Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism / A. E. SHINDLER in Journal of Autism and Developmental Disorders, 50-1 (January 2020)
[article]
Titre : Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism Type de document : Texte imprimé et/ou numérique Auteurs : A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : Autism Constipation Diarrhea Gastrointestinal dysfunction Nausea Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research. En ligne : http://dx.doi.org/10.1007/s10803-019-04231-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.76-86[article] Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism [Texte imprimé et/ou numérique] / A. E. SHINDLER, Auteur ; E. L. HILL-YARDIN, Auteur ; S. PETROVSKI, Auteur ; N. BISHOP, Auteur ; A. E. FRANKS, Auteur . - p.76-86.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.76-86
Mots-clés : Autism Constipation Diarrhea Gastrointestinal dysfunction Nausea Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research. En ligne : http://dx.doi.org/10.1007/s10803-019-04231-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414